Increase Height And Grow Taller Using Magnetic Resonance Image, MRI Guided High Intensity Focused Ultrasound Surgery, FUS (Big Breakthrough!)

Of all the techniques and ideas I have proposed so far this may be one of the most technologically advanced ideas and proposals. Recently I was watching a talk on TEDtv called “Yoav Medan: Ultrasound surgery — healing without cuts” and I wondered whether it would be possible to use this type of non-invasive surgical method to increase height. After spending a few hours looking at the various resources and PubMed studies on the internet I would say that this medical technology procedure actually has some good height increasing possibilities. Let me explain.

The video is below. A full analysis of this possible method and approach is talked about below the video.

 

Sources

Analysis & Interpretation

From the 5th source, “Magnetic resonance (MR)-guided focused ultrasound surgery (MRgFUS) completely destroys targeted tissue without causing structural or functional damage to the adjacent tissue. The ultrasound energy penetrates normal tissue while reaching targeted tissue at sufficiently high energy levels and inducing cell death with minimal interference. MR imaging (MRI) identifies targeted tissue and detects suitable access routes for the acoustic waves. It also determines tissue temperature changes. MRI contrast scans then verify thermal ablation. Thus, an effective, safe, non-invasive, closed-loop procedure eradicates circumscribed tissue with minimal discomfort and recovery time. Described as the ideal surgery,….”

The real method for non-invasive surgery has arrived. With it, that suggests that we can finally make surgical incisions on places without needing to cut open skin. The technology I am looking at is very advanced and its main application has been towards killing (or at least stopping the growth) of brain tumors which are malignant. However I would suspect that if the frequency and magnitude of the ultrasound surgery can be increased, it can turn into a device that cuts anything including the hard nature of the hydroxyapatite, which is what gives bone their hard nature.

Implications For Height Increase

Here is what I can say to all the people who are interested in height increase. The non-invasiveness nature of any type of technique can probably be achieved now using the MRgFUS . If the device is strong enough, it can make cuts into the hard non-living tissue of the bone, the extracellular matrix of the bone. A quick tensile load means that along with the initial bone cut, the pulling can mean that limb lengthening surgery can be done extremely precisely.

I had talked about before in previous posts about the use of Low Intensity Pulsed Ultrasound (LIPUS), Extracorporeal Shockwave Technology (ESW), as well as High Intensity Pulsed Ultrasound. Now we are seeing high intensity ultrasound which is non-invasive in nature. Any cuts and incisions made on the bone can be done with no cuts on the skin.

I had talked about before using Piezoelectric Surgery as a way to cut bone for microfracture formation and distraction osteogenesis in the post “Increase Height And Grow Taller Using Minimal Invasive Piezoelectric Surgery, Part I” bringing up the issue that if we can figure out the resonance frequency of the long bone in each of its areas, including the cortical bone area and the trabecular bone area,

Here is the method I propose to regrow cartilage in the areas we want now non-invasively. 

1. First we get an X-ray of the limb to be done on to know exactly where the outer edges of the bone is.

2. We can apply a sharp but high intensity pulse to the now gone epiphyseal cartilage bone area, and by using the resonance frequency of the bone type, we can induce the bone material to break apart in that area using the High Intensity Focused Ultrasound devices.

3. Remember that the Parathyroid organ is what regulates the calcium in our blood. If we can regulate the PTH/PTHrP calcium homeostasis so the calcium deposits get resorbed by the blood (like osteoclasts) leaving a relatively empty space filled with bone marrow we can do what I would call the first filtering of the marrow to get ready for cartilage formation. I had talked about the possibility of using the Parathyroid related Peptide, PTHrP as a way to lead to noninvasive height increase in one of the most interesting posts “Parathyroid Hormone And Parathyroid Hormone-Related Protein May Lead To Non-Invasive Epiphyseal Growth Plate Regeneration (Big Breakthrough)“. Since the increase of PTH means that the calcium in bone gets resorbed back into the blood leading to a medical condition known as hyperparathyroidism , we must only get the PTH/PTHrP to be increased in the area where the bone material was dissolved. This might be achievable from somehow getting the indian hedgehog  (Ihh) to be increased in expression within the MSCs inside the marow which would expand and fill up the  newly formed medullary cavity.

4. The bone marrow inside has MSCs but has a type of bone marrow known as yellow marrow, which doesn’t have the red bone marrow of children, having what is known as adipocyte derived MSCs. From pubmed studies…

This shows that with growth factor combinations like TGF-Beta2 with BMP7 and the combination TGF-Beta3 with BMP-6 (from the 2nd source) which we can inject into the bone area with a small drill can stimulate the initial chondrogenesis process. We would do a weekly injection of the right growth factor combination to create more chondrocytes.

However the issue would be whether we can use just the Magnetic Resonance Imaging Guided High Intensity Focused Ultrasound (MRgHIFUS) alone in achieving cartilage formation inside the bone without needing anything else. I would actually prefer that after the MRgHIFUS usage to break apart the bone areas in the location we wish to, we inject growth factors like GDF-5, FGF-3, and TGF-Beta1,2,3

5. Which we can use another frequency, a lower frequency from dynamic mechanical loading to cause more chondrogenesis. The idea now is to convert the few chondrocytes that are made from the growth factor injections into a culture form to make a culture to form cartilage.

6. From the previous post “Thyroxine Regulates The Morphogenesis Of Isolated Chondrocytes Into Columnar Cartilage (Big Breakthrough)” I would guess that if we can inject thyroxine into the now marrow filled cavity of the bone, it might be able to get the chondrocytes that do get differentiated to start stacking in columnar fashion to create a extracellular environment similar to the original growth plate.

6. We must remember that vascularization is what causes cartilage tissue to start turning into bone. This means that the high intensity focused ultrasound needs to be used regularly to destroy blood vessels which would try to either differentiate the adipose derived MSCs into osteoblasts an osteocytes. Of course this is easily done since the original application of the MRIgHIFUS (or MRIgFUS) was to destroy blood vessels which would supply the nutrients needed to allow tumours to continue to grow.

7. After a cartilage is mostly formed for the layer in the long bone internally for the trabecular bone area, we can then do it to the cortical bone, and doing the same process over again.

This will be the first time that we can use real technology to rebuild cartilage that was completely lost during the natural growth process. However the cartilage formed may not be the nice hyaline type we are looking for with stacked chondrocyte columns. Some of the cartilage formed may be irregular or crooked but I would guess that as long as a layer of cartilage can separate hard bone from hard bone, we can use other cartilage forming ideas like injecting Chondromodulin Type 1 to stop vascularization to increase the cartilage thickness.