What I have found recently is a patent which shows how we even as amateur experimentalist can probably get the raw materials needed to do this experiment to show that using bFGF and Hyaluronic Acid can get bones to growth, at least in terms of thickness.

The patent is rather long so I will not be attempting to copy and paste on this post everything that was written in the patent. I only copied the abstract, patent description, and the claims made by the inventor.

Analysis & Interpretation

From a first glance it looks like the patent for the invention involves a two part composition mixture that is supposed to be applied to the area of bone one would like to thicken. The composition that is formed from getting the hyaluronic acid and basic FGF growth factor would have the viscosity level and and biodegradability level to stay in the area of bone long enough to have some type of osteogenic effect.

For the actual growth factor, there might be more than just FGF involved, but also the TGF-Betas 1-3, IGF-1, PDGF, EGF and other elements in the TGF-Beta superfamily. The inventor is better at describing the invention with….

“A method of treating diseased, injured or abnormal bone at an orthotopic or intraosseous site of desired bone growth…”

To get into specifics, if we are choosing the basic version of the FGF growth factor, we would use concentrations at 10.sup.-6 to 100 mg/ml and the Hyaluronic Acid would need to be around 0.1-4.0% by weight percentage.

Implications For Height Increase

This type of invention is interesting to  consider since it might be the type of method or technique which for the height increase seeker means that they might be able to take a type of syringe and inject the bone growth material on the edges of long bones to stimulate layer upon layers of appositional bone growth. The process of using this idea for height gain will be very slow.

However this type of patent is useful to note for later research if the case where we need to form bone growth quickly can be done using this mixture of growth factor and hyaluronic acid.

Method of promoting bone growth with hyaluronic acid and growth factors

Michael Radomsky

A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at the site of desired bone growth for a period of time sufficient to promote the bone growth. Preferably hyaluronic acid is used in a composition range of 0.1-4% by weight and preferred growth factor is bFGF, present in a concentration range of about 10.sup.-6 to 100 mg/ml.

SUMMARY OF THE INVENTION

The present invention provides a bone growth-promoting composition comprising hyaluronic acid and a growth factor such that the composition has a viscosity and biodegradability sufficient to persist at the site of desired bone growth for a period of time sufficient to promote bone growth.

Compositions comprising hyaluronic acid and a growth factor are provided which have the requisite viscosity and biodegradability.

As used herein, the term hyaluronic acid, abbreviated as HA, means hyaluronic acid and its salts such as the sodium, potassium, magnesium, calcium, and the like, salts.

By growth factors, it is meant those factors, proteinaceous or otherwise, which are found to play a role in the induction or conduction of growth of bone, ligaments, cartilage or other tissues associated with bone or joints.

In particular these growth factors include bFGF, aFGF, EGF (epidermal growth factor), PDGF (platelet-derived growth factor), IGF (insulin-like growth factor), TGF-β I through III, including the TGF-β superfamily (BMP-1 through 12, GDF 1 through 12, dpp, 60A, BIP, OF).

What is claimed is: