Monthly Archives: February 2013

Increase Height And Grow Taller Through Surgery, Osteotomy For Back, Spinal, Or Vertebrate Curvature From Scoliosis And Ankylosing Spondylitis, From Korea With Doctor Kim Ki Taek (Breakthrough!)

I am pleased to finally say that there is indeed a way to treat the great back curavtures we have found in some older individuals.

The height increase that is possible from this South Korean doctor Dr. Kim Ki-Taek from some university’s Department of Orthopedic Surgery.

From the video we would learn that Dr. Kim Ki-Taek would learn about a surgical technique from abroad in 1995 on this surgical technique and brought it back to his home country. HIs accomplishments from the video indicate that he has performed…

  • Crooked Neck Corrective Surgery – South Korea’s 1st successful case without any nerve damage
  • Foreign Researcher Award from Japanese Orthopaedic Association (JOA)
  • Korean Society Of Spine Surgery

The man in the video being treated has his head about 20 cm off from where his head should be. This means that he is losing about 3-4 inches of height from not being able to lift his head up for proper posture correctly.

Dr. Ki-Taek notes that in most cases, the spine curvature will occur in the lower back area. For the patient on the video, his curvature is in the middle of the vertebrate, in the thoracic region. The surgery performed is called Corrective Surgery for Ankylosing Spondylitis (AS).

The negative part about the surgery when related to height increase or height is that the physicians will remove 2 sections of the vertebrate stack so that the vertebrate that is left after the removed vertebral will be able to be repositioned for the patient’s torso and body be put back up on a up-right position. The issue is that because you are cutting away a large portion of the vertebrate, the vertebrate stacking will no longer be completely upright, but involve the vertebrate stacking on top of each other in a skewed fashion. I would guess that this would result in maybe 2-3 inches of lost height from partial vertebrate removal.

Subsequently, after the bone removal, metal screws are put into the man’s vertebrate with different sized screws for different vertebrate sections. The screws are then held together with support using a bent metal rod attach to the other ends of all of the screws, thus forcing the newly aligned vertebrate into its new way. The curved rod is thus contouring the new vertebrate curvature.

What is noted in the video is that apparently with advanced age, spinal or vertebrate curvature and issues are likely to develop. Things like Kyphosis or Lumbar Stenosis can set in and cause not just a cosmetic issue with looking shorter to hunched, but also cause great pain and decreasing the quality of life for the people suffering from these types of ailments.

At Kyung Hee University Hospital at Gang Dong located at Gangdong-gu, Seoul, in the department called Kyung Hee Spine Center it seems where Dr. Ki-Taek is located. He also treats young, still growing taller kids who might be suffering from the common back ailment of scoliosis. Scoliosis is similar to Ankylosing Spondylitis from it’s symptom of spinal and/or vertebrate curvature which causes a person to have bad posture. Dr. Kim Ki-Taek says, “We’re trying to straighten out the curvature of the spine in growing children. So we apply pressure here to stop it from bending. We can straighten the spine by tying this together. But we won’t be able to salvage any joints. In this case we have to save as many joints as possible.”

We find that the the spine curvature has changed in 2 years of the young girl patient from 12 degrees to 62 degrees. Corrective Surgery for Scoliosis has become the only option. To make allowances for the young girl’s future growth spurts, since she is still growing, Dr. Ki-Taek must calculate how much bone must be removed.

As the good doctor says, “Straightening the spine is not the sole objective.” After the operation, the young girls’ spine has been straightened satisfactorily. When her mother goes to see her after the surgery, her mother notes that not only does the girl’s back and pelvis look correct now, the patient is also 3 cms taller and her pelvis is growing correctly.

Conclusion: 

I am happy to say that through just ordinary research and searching on the internet, we have found another way to increase height using a surgical process which cures people with spinal or vertebral curvature like from those suffering from Scoliosis and Ankylosing Spondylitis.

From the Wikipedia article on Ankylosing Spondylitis we learn that this condition

From YouTube video entitled “Medical Korea | World’s first osteotomy for spine deformity


Growth 247 Formula – Review On Another Height Increase And Grow Taller Program

Recently while doing research for another post I found another program that is being sold on the internet as a path towards height increase/grow taller. The website goes by the name of growth247formula.com.

Since I am willing to check out and analyse any ideas that are proposed, I wanted to see what the product is about.

This is what they say on the one page sales page…

“Growth 247 Formula has now been scientifically proven to improve people’s height by 2-4 inches within only a few weeks. Our formula has helped thousands of people all around the world increase their height and regain the self confidence they once lost. The results are so amazing that we have gone extremely viral, more and more people have started following the Growth 247 Formula because of the fantastic results their friends and family members are having. This formula does not include any miracle pills, secret diet recipes or anything of the sort, we just provide a complete step by step way for you to increase your height, with backed up scientific evidence of natural height growth.”

Analysis & Interpretation: 

I was curious at what the program was so I clicked on the Download button to see what would happen and it took me to the page for the product GrowTall4Idiots which has been sort of a running joke to the people who come to this site. When I tried putting the term “growth 247 formula” into google, the only other real link was to this website HERE which is just a link directory page which does nothing. Other results on google showed that whoever created the website growth247formula.com has been going to certain sites with relevant, similar information and had been spamming the pages with a short testimonial sales phrase.

Then after looking at the webpage again I realized that the page was just another sales letter page which is to redirect any visitors back to the GrowTaller4Idiots main site. I had forgotten about all the fake websites I had to scour through in the beginning of the development of this website.

At the bottom of the page there is a logo that says that this product has been featured on Fox News, Dr. Phil, CNBC, CNN, Wall Street Journal, and many others but I am guess that part is a clipped jpeg or logo from some other website to make it seem like whatever is being sold has more legitimacy. Well it doesn’t. It just shows that the person who put up the website is directly lying to us. The product GrowTaller4Idiots has never been featured on any of the major media or news outlets.

Conclusion:

The product that the webpage is trying to sell is the scam product GrowTaller4Idiots. The page itself does not sell any real program or device but only put another different name on so you will get tricked. Maybe the internet marketers who put up the website is thinking that with more people who can be tricked into being directly back to the main grow taller 4 idiots sites, they will get more sales. However that approach doesn’t work and there is not way for them to increase sales. There is no product called Growth247 Formula. It is a fake name for a very well known height increase scam. Run away from this stuff as much as you can and find a credible source.

 

Using Extracorporeal Shock Waves, ESWs To Stimulate Periosteum Osteoprogenitor Cambium Cell Proliferation In Non-Invasive Bone Tissue Engineering Application ( Big Breakthrough!)

Something which I have always guessed could really work in making people grow taller was the use of Extracorporeal Shockwaves. I had written before at least multiple posts about the possibility, showing the dozens of PubMed articles all suggesting that ESW therapy works in bone healing and bone growth, but also the possibility to cause chondrogenesis and chondrocyte proliferation. The post where I wrote about this idea was “New Proposed Height Increase Method Using BMPs And Extracorporeal Shock Wave Treatment, ESWT

For the Full version of the entire article, click HERE

Title Of Thesis: Non-invasive shock wave stimulated periosteum for bone tissue engineering

Kearney, Cathal (Cathal John) – Harvard University–MIT Division of Health Sciences and Technology.

Thesis (Ph. D.)–Harvard-MIT Division of Health Sciences and Technology, 2011

The cambium cells of the periosteum, which are known osteoprogenitor cells, have limited suitability for clinical applications of bone tissue engineering due to their low cell number (2-5 cells thick). Extracorporeal shock waves (ESWs) have been reported to cause thickening of the cambium layer and subsequent periosteal osteogenesis. This work proposes that ESW-therapy can be used as a non-invasive, inexpensive, and rapid method for stimulating cambium cell proliferation, and investigates the use of these cells for orthotopic bone growth. The response of periosteal cells to ESWs was evaluated using two different energy densities applied to either the intact femur or tibia of the rat. Just four days after application of ESWs, there was a significant 3- to 6-fold increase in cambium cell number and thickness. The most effective treatment of those tested was high dose ESW applied to the tibia. Immunohistochemical staining of the proliferated cells demonstrated osteoblasts and bone formation (osteocalcin stain); it also demonstrated extensive vonWillebrand factor expression, which reveals the vascular contribution to the proliferating cambium layer. In a rabbit model, ESW-thickened cambium layer cells were overlaid in situ on a porous calcium phosphate scaffold. At two weeks post-surgery, there was a significant increase in all outcome variables for the ESW-treated group when compared with controls: a 4-fold increase in osteoprogenitor tissue in the scaffold upper half, a 10- fold increase in osteoprogenitor tissue above the scaffold, and a 2-fold increase in callus size. The results successfully demonstrated the efficacy of ESW-stimulated periosteum for bone tissue engineering.

Analysis & Interpretation:

The thing about Ph. D programs are that they are very long and mentally intensive. What is well known is that for a person to be awarded a degree in graduate school, for say a Masters or Doctorate, they have to do more than just regurgitate the information that is already in the scholarly books, but create something new or answer some question which has not been answered yet. Also, Ph. D. Thesis tend to be more like novels since they are almost always over 100+ pages in length. This means that I will NEVER take that much time in analyzing every single sentence.

However I will explain why this MIT Thesis from 2011 is so important. It shows that we have finally discovered a real way to increase out height noninvasively, through the application of a type of vibration or wave to stimulate cell proliferation in an area of the body which can be stimulated since it still has progenitor mesenchyme-like cells which can differentiate into the type of cells we are looking for. 

From my analysis of just the Abstract this is the real deal.

Not only does this show finally the first real to way to increase our height, it also validates one of the primary ideas I have been having, which is that we might be able to manipulate the cambium cells in the lower periosteum layer to grow in thickness from proliferation. 

Increased thickness means the end of our long bones in our legs would be thicker, which translate to extra height.

If you are a true researcher, then I would suggest you go through the pages 40-52 where the Ph. D candidate goes into the introduction on the periosteum and the responses to extracorporeal shockwaves. The Thesis has results sections, but I would rather just focus on reading the “discussion” sections to see how the researcher is interpreting the data. I would assume that a person who has managed to make it through the Ph. D program in the hard sciences or engineering from MIT is intelligent enough to read and interpret the data they have received correctly, since they probably have been working on the problem for at least a couple of years.

They state …

“The focus of this thesis is the generation of bone orthotopically using ESW-stimulated periosteum in combination with a subperiosteally implanted porous cal- cium phosphate scaffold. ” (pg. 43 of 225)

This may mean that the person is only doing the research to make bones stronger and have greater bone mass density (BMD) to treat aged people with osteoporosis but it also shows that the results mean that applied the right way a subject can in theory gain a little bit of height increase.

Let’s look at this picture I clipped from page 44 which shows the diagram on how autologous chondrocyte transplant or autologous chondrocyte implantation (ATI) treatment would work.

autologouschondrocytetransplant


This is how the general implantation is supposed to work. However the technique here is specified for using a periosteal flap for a place to get chondrocytes. in using the periosteum. The rather sucky thing is that this guy did not decide to look at how feasible it would be to use periosteal tissue in cartilage tissue engineering and cartilage regeneration. They focused on bone growth.

From page 45 in the section 1.3.2 entitled “Thickening of Periosteal Cambium Layer”

Thickening of periosteal cambium layer

Previous investigators have reported techniques aimed at thickening the cambium layer of periosteal cells for use in tissue engineering strategies. O’Driscoll’s group injected TGF-#1 subperiosteally to stimulate periosteal proliferation and to initi- ate chondrogenic differentiation of the cambium cells (Reinholz et al., 2009). Simon et al. (2003) investigated the use of surgical techniques to stimulate periosteal cell proliferation in a caprine model. The authors performed surgical release of the pe- riosteum which resulted in cambium cell proliferation and subsequent bone formation within the proliferated layer 

From Section 1.4 on Extracorporeal Shockwaves…

Our supposition is to employ extracorporeal shock waves (ESWs) as a non-invasive and rapid way of safely and reliably stimulating the proliferation of the periosteal osteoprogenitor cells for use in orthotopic bone generation strategies after only a few days 

Importantly for this study, ESWs have been reported to stimulate periosteal osteogenesis following thickening of the periosteal cambium layer (Takahashi et al., 2004; Tischer et al., 2008). For medical applications, the peak ESW pressures lie in the range of 5-12OMPa; the rise time is on the order of 10-100ns; and the pulse width is on the order of 1ps (Chung and Wiley, 2002; Gerdesmeyer and Lowell, 2007).

 

We have to clear evidence from at least two studies that the ESW would work in making the bone ends thicker then.

Under Section 1.5 for Thesis Goals….

This thesis deals with a new therapeutic approach for regenerating bone orthotopi- cally. The emphasis is on growing bone on the cortical bone surface, which would have applications in bone regeneration in oral and maxillofacial surgery (e.g., alveolar ridge resorption), as well as in orthopaedics (e.g., osteolysis). The central hypoth- esis is that extracorporeal shock wave (ESW)-stimulated periosteum enhances bone formation in porous biomaterials implanted under the periosteum. The overall goal of this work is to demonstrate the efficacy of an ESW-thickened periosteum as an overlay on a porous calcium phosphate scaffold for the orthotopic growth of bone.

If we just skip to pages 72-75, where the Ph. D Candidate writes in the Discussion and Summary section…

Section 2.4

The objectives of this study were to determine the effects of energy flux density (0.15 vs. 0.40 mJ/mm2) and anatomic location (femur vs. tibia) on the periosteal cambium layer cell number. For all groups evaluated, cambium layer cell counts, and cambium layer thickness, were significantly increased following ESW treatment when compared to controls. The higher dose of ESWs resulted in a thicker periosteum compared to the lower dose (Group 3 vs. Group 4; t-test, p<.0001), which is consistent with previous findings (Tischer et al., 2008). However, the results presented here demonstrate a lower threshold for periosteal proliferation (0.15mJ/mm 2 ) when compared with a previous study that reported a minimum energy density of 0.5mJ/mm 2 was required for periosteal osteogenesis (Tischer et al., 2008). The data presented here show that a lower energy density, which reduces inflammation, can be used to stimulate the cambium cells. Tibial periosteum displayed a greater degree of cellular proliferation in response to ESWs compared to the femur (Group 3 vs. Group 2; t-test, p<.0001; tibia vs. femur). The larger amount of soft tissue surrounding the femur may cause more attenuation of the shock wave than occurs for the tibia. 

Conclusion:

From Sections 1 and 2, we have clear evidence that bone growth can rather easily occur from ESW application on the cambium layer of the periosteum. With higher dosages, at least to a energy flux density of 0.40 mJ/mm^2 the cell layer gets thicker. However the even better news is that the threshold for cell proliferation is lower than the results found from previous studies.

Section 3 is more interesting. The graduate student tried to figure out what types of cells are really found in the cambium layer and he says that the layer of tissue has mostly osteoblast-like progenitor cells, which can be labeled as mesenchyme and sort of “stem-like”. The problem for our goals is that the cells seem to favor and almost always take the path of differentiating into the bone cells, not cartilage cells. They note that previous studies seem to see the same thing, that the cambium progenitor mesenchyme go through the process of intramembraneous ossification, not endochondral ossification. When they checked to see if the cells left any Collagen Type II or Type X, suggesting chondrocyte production and chondrocyte hypertrophy, they found none.

For our guesses that the bone formation is from microfractures induced, the candidate says it is not likely, or that it could be periosteal elevation. What is most important is to show that vascularization is almost immediate after ESW treatment, which might explain why differentiation into osteoblasts are the main pathway goal than chondrocytes.

The reason for the vascularization and the intramembraneous ossification seems to be from two new proteins which I am not familiar with called SMAs and vWFs (VonWillebrand factor) which seem to be found a lot from endothelial cells.

This makes the candidate believe that the endothelial cells might be stem-like and multipotent differentiating only into bone cells when the ESW is applied causing vascularization.

At this point, we end Section 3 and the summary, and reach around page 95 of this 225 page Ph. D. I will probably try in a post later to go through this entire Ph. D and explain away the other sections to explain what all the technical jargon implies. The big thing to take away from this post are these two points.

  • ESW application even at a lower energy flex density does cause the periosteum to grow more bone from cambium cell thickness increase, which means we will grow taller by a little using this non-invasive method. 
  • The problem is that the ESW causes osteogeneis but not chondrogenesis, which is what we should really be focusing on to get grow taller by a much larger amount. Osteogenesis might increase our height by 1 cms maximum (a personal guess) but Chondrogenesis could lead to hypertrophy and multiple inches in height increase.

Medical Analysis On A 8 Feet Tall Iranian Giant, Siah Khan

I have talked about Siah Khan And Zech Devits before in the posts “The Development Of Gigantism Without Pituitary Abnormalities: Studying Zech Devits And Siah Khan, (Important!)” and “The Connection Between Matt McGrory, Siah Khan, Zech Devits, And The Tallest Filipino Leads To Proteus Syndrome And Much More (Important!)

This post is to focus more on what could be the genetic mutation which lead to Siah Khan. His case is one of the most unique, and most interesting of all giants I have studied. The abnormalities found on his face makes him so unique that there has really only been 1 case of his type in all of documented medical history.

The main resource I have to use was the study “Cranio-Spondylo-Tubular Dysostosis A Unique Historic Iranian Giant” –

Note: I do have a copy of the full PDF of the study somewhere on this website.

Author(s): Mohammad Hassan Sheikholeslami, Yousef Shafeghati , Zabihollah Ghorban

MD – Tele-fax: +98(21)44 633 283

Article abstract:

Severe overgrowth and tallness is very rare in human beings. The most common cause is gigantism due to the excessive secretion of the growth hormone, especially, before the closure of long bones’ epiphyseal growth plates. There are other rare disorders that are categorized on overgrowth syndromes. Herein, we report an extremely rare, or even perhaps a unique, patient from Iran. The clinical and skeletal findings were very unusual, with extensive clavarial, tubular, vertebral, ribs, and scapular overgrowth and synostosis. Indeed, the results of these abnormalities made a monstrous giant with a very tall stature. This is a unique case, which was living during 1912-1940 in Shiraz. The report’s information and photos, kindly supplied by Prof. Sheikholeslami. We evaluated thoroughly the findings together. Now we think; this is a very unusual case of its type, perhaps a Craniotubular Dysostosis Syndrome. We searched medical and clinical genetics literature, but did not find any similar case, having been reported before. So, to our knowledge, this is a unique case in the history of world medicine. We suggest to call this entity; “Siah-Khan syndrome” (after the patient’s name), or “ Ghorban-Sheikholeslami-Shafeghati Syndrome” (in honour of Prof. Ghorban who was recently has died, or “ Cranio-Spondylo-Tubular Syndrome”.

The other main website to see what Khan was like is from a website that is almost all in Arabic (click HERE)

Analysis & Interpretation:

Sometimes the doctors or researchers who study these giants are too busy taking pictures, and trying to handle all the press and media from having such a patient that they barely ever do any science or analysis on why this Iranian giant ever even existed. The other title given for the study was “A Unique Historic Iranian Giant “Siah-Khan Syndrome”, Report of an extremely rare or perhaps a unique case in the world from Iran”. The paper first states that this guy was born in the early 20th century to a normal family (father and mother and siblings are all normal). His birth shows that he was average sized. His growth spurt started around the age of 6 and by the time he was 9 years old, he looked like a guy who was 20 years old. Siah Khan started to develop deformities on his skull, face, arms, and legs and young kids started to become very scared of him. Eventually the family managed to get in contact with a Professor Ghorban in 1922. Khan was subsequently put in the hospital for care. He stayed there until he was 28 years old, when he died from pneumonia and sepsis in 1940. After his death, the professor felt his body was too precious and unique so didn’t bury it but put it up for display, where it is supposed to be presently in the main entrance of some university called Shiraz Medical Science University.

The paper itself is only 5 pages long and says that Khan was 259 cms tall and 250 kgs. If the numbers are true, that means Khan was standing around 8 feet 6 inches tall! It is also written that Khan is supposed to be mentally below average with a huge sexual apetite and could not turn left or right, or even stand up from sitting down. There is clear bony projections on the person’s face. 

They state….

Occipital bone growing backward.

– Frontal bone growth progressing to the forward and downward of the eyes as a thick wall limiting the field of vision just like a front porch.
– Large hands with long fingers.
– Large feet, very flat feet, bumping steppage.
– Great appetite as much as 3 to 4 people with good appetite.
– Looking like a strong, dry piece of thick wood and unable to move in different directions because of the fast growth of bones and early vertebral body fusion 

The height of the skeleton is 259 cm; the lengths of the upper extremities were 117 cm, and the lower extremities 125 cm. The very severe overgrowth in calvarial bones, clavicles, scapulae, long tubular bones, ribs, and pelvic bones are apparent. 

tibia porosityI personally took the liberty to clip and put the picture in the article of Khan’s only 2 X-rays, of his skull and his lower limb bones. It is noted that his tibia and also fibula was rather enlarged and sort of porous.

The physicians are right that there can be many different causes and reasons for gigantism, which is supposed to be labeled as any person who is 3 or more standard deviations above what the average height of people in their main group should be. After listing through what could have cause the gigantism and bony overgrowth on face, the Iranian researchers seem to suggest that Siah Khan suffered from something called Craniodiaphyseal dysplasia. As they say it…

Craniodiaphyseal dysplasia (CDD) is a rare craniotubular remodelling disorder with hyperostosis and sclerosis of the skull and facial bones, along with hyperostosis and defective remodelling of the shaft of the tubular bones. The epiphyses and metaphyses are only mildly affected.  

The other disorder which they sort of claim could be the cause is something called Craniometaphyseal dysplasia (CMD)

In Craniometaphyseal dysplasia (CMD), there is progressive facial dysmorphism with a broad osseous prominence of the nasal root extending across the zygoma. Autosomal dominant and autosomal recessive types of inheritance have been described. In general, recessive CMD is more severe than the dominant CMD 

The thing which the scientists at that time, and which we as height increase researchers can only say is that Siah Khan suffered from a very sever form of CDD or CMD, and his case is very unique. There was little blood work and no genetic studies done on him, since he lived in the the early 20th century. If he was born in the 21st century, we probably would have been able to help him out much more and be better and figuring out what exactly caused his condition.

siah khan 2

siah khan

siah khan

The Development Of Gigantism Without Pituitary Abnormalities: Studying Zech Devits And Siah Khan, (Important!)

In the last post I had found from forums off of other websites that there have been a few people who developed a type of gigantism without going through the normla pituitary abnormalities we are used to seeing. It seems that through certain genetic mutations, a few people have managed to develop gigantism.

The paper I would cite at the end of the previous post “The Connection Between Matt McGrory, Siah Khan, Zech Devits, And The Tallest Filipino Leads To Proteus Syndrome And Much More (Important!)” was entitled “A provisionally unique syndrome of macrosomia, bone overgrowth, macrocephaly, and tall stature

Abstract

We report a young man with intrauterine macrosomia, macrocephaly, and bony abnormalities. Excessive growth continued throughout infancy and childhood. Bone age was advanced. He developed contractures of the large joints and was confined to a wheelchair. Extensive laboratory studies, repeated on multiple occasions were all normal. Intellectually, he was normal. His near final height was 234 cm. The constellation of findings in this patient is at variance with previously described syndromes of tall stature. We postulate that excessive size and bone overgrowth in this young man is caused by a receptor/post-receptor abnormality involving a growth on/off mechanism at the cellular level.

I would take the 4 page full file from the forum thread HERE from TheTallestMan.com website. An expanded view of the 4 pages is available from the forum. For the analysis of the study go to the bottom of the post. There is actually also a whole treasure trove of studies and articles that a serious height increase researcher can mine from to learn more about how human growth occur.

11

121314

Analysis & Interpretation

The study that we find from 2005 was done on the giant Zech Devits who has passed away. He was measured (or maybe guessed) at a truly staggering 7′ 8″ tall. His large ears might have given off the fact that his height may be the result of excessive cartilage formation of hyperplasia.

From the abstract we learn that this patient had an above average sized skull, joints, joint curvature. HIs intellect seems to be intact. Besides the multiple issues the doctors and researchers might have found in his major organs, the skeletal structure showed mild contracture of the elbows and knees, the flaring of the long bones in the metaphysis region, and the curvature of the vertebrate aka thoracolumbar kyphosis. There was also thoracic dystrophy and diffuse bone dysplasia. What is really interesting to see from the charts of the blood tests is that the patient was not hypersensitive to the traditional growth factors which would cause overgrowth like insulin, growth hormones, or insulin like growth factors, IGF-1. At at the age of even an infant he was documented to have had spinal fusion. Around the age of 2 testing found that he was suffering also from severe spinal stenosis. At the age of 4.5 there was more signs of spinal atrophy.

Before even the age of 10, he was already almost 6′ 7″ (200 cms). Bone density decreased, myopia set in. From doing the bone maturity test using the Tanner method, his bone age around 9 showed that he was progressing at the average rate of most kids. His eyebrow and forehead developed, his ears grew out to be quite big, and his nasal bridge also increased. This suggest that the places of cartilage really decided to increase in size. Eventually his conditon got really bad and the people who were monitoring him decided to give him 200 mg/ week to speed up the bone maturation and fusion process.

From the discussion we would learn that while Zech was born prematurely, he was a big baby. The researchers note that his facial features resemble patients which have Sotos Syndrome or Weavers syndrome as well as Marfan’s Syndrome.

He had weakness in the upper body, moderate acne (which would suggest that his growth process of going through puberty since males start around 10-12 was normal for age range), and a very deep voice. This suggest again that his condition caused cartilage hyperplasia, since the pitch of one’s voice comes from how wide the cartilage of the windpipe (aka trachea)  and voice box (aka larynx) are. The wider the speaking windpipe and voice box, from say chondrocyte hypertrophy or proliferation, the deeper one’s voice.

What seems to be ever more interesting is from the photo in the article is that his head is very large compared to the average person. It is noted that he has supra-orbital ridges or what the common person would say is a very distinct, large eyebrow ridge which juts out. His hands and feet were large (size 22-23) but his fingers seemed to be relatively short. From X-rays done, it was found that he had most of the epiphyseal growth plates already starting to fused together even at the age of 12.5 from the estrogen-like hormone treatment, including the radius, femur, and tibia.

The conclusion the physicians who were trying to figure Zech’s condition out basically are not sure whether he was suffering from Weaver’s Syndrome or Soto’s Syndrome, but only that his asymmetrical nature of growth could be from Proteus Syndrome since Proteus Syndrome leads to asymmetrical overgrowth.

I would conclude this case of gigantism and over growth with a clip on the analysis the physicians gave on his condition and what might be the cause. At this point I don’t understand what they are talking about. What is clear to realize is that for Zech, he did not suffer from some type of hypogonadism or pituitary problem like most giants, but had some other type of disorder.

zetch

The Connection Between Matt McGrory, Siah Khan, Zech Devits, And The Tallest Filipino Leads To Proteus Syndrome And Much More (Important!)

This find I have made is one of those studies that really help push our research a little further and can help us understand better other possible ways to stimulate height increase.

mattmcgroryWhile I was going through an old haunt or old forum I used to frequent, on TheTallestMan.com forum, I would come across a thread that was entitled “The matt mcgrory gigantism?“. In this thread the posters were trying to figure out whether the now deceased Matt McGrory had the traditional type of gigantism that one would find in pituitary giants.

What these guys have found is truly startling in scope and I wanted to share the information that they managed to find.

It would seem that at least 4 giants that have lived in the last century have all been suffering what could possibly be the same type of genetic abnormality. The #1 likely condition that the people on TheTallestMan.com forum suggest is that all 4 men, Matt McGrory, Siah Khan, Zech Devits, and the The Tallest Filipino aka The Tallest Man In the Philippines have been suffering the Proteus Syndrome.

  • The profile on Matt McGrory on the TheTallestMan.com can be found HERE.
  • The profile on Zech Devits on the TheTallestMan.com can be found HERE
  • The profile on Siah Khan Ibn Kashmir Khan on the TheTallestMan.com can be found HERE.
  • The forum thread on The Tallest Filipino aka The Tallest Man in the Philippines can be found HERE.

Note: Interestingly, from this article HERE on ABS-CBN News it is suggested that the tallest man in the philippines is someone named Raul Dillo. From sources we find out that Raul Dillo is claimed to be 7′ 3″ tall who played professional basketball in his native country of Philippines on the team San Juan Knights of the MBA. There is a profile on Raul Dillo on TheTallestMan.com HERE. It seems that Raul Dillo, who I would guess is actually the tallest filipino native, suffers from acromegaly.

Geting back to the original forum thread, what I find is that the people on this forum apparently have a passion on finding giants and documenting them correctly, which is similar to my obsession on height and height increase. The first poster who goes by the name JuanCarlos states…

zechdevits“The characteristics I have observed on these three individuals (Mcgrory, Devits and the discussed tallest filipino) are really abnormaly long feets and hands (In comparation of their height.”

So we know that these giants who look even more abnormal than say “normal” giants have even greater disproportion in their body parts. The main arguement on the idea that these giants don’t suffer from the Proteus Syndrome is that proteus syndrome causes Asymmetric Growth. However this argument against Proteus Syndrome was rebutted by a poster named Roger

“Looks like Proteus syndrome is an extremelly variable condition, with great clinical variability, that can produce hypertrophy of tissues and an increase in size (partial giantism), uncontrolled bone, skin growth…”

Roger also notes that Proteus Syndrome has been traditionally associated incorrectly with the condition known as Neurofibromatosis. Now, We could get into a whole other post and discussion on the link between Proteus Syndrome, Neurofibromatosis, and The Elephant Man aka Joseph Carey Merrick (whose name is sometimes mislabeled John Merrick) but we won’t get into that right now.

Here are the heights that we know about the giants. Matt McGrory when he was still able to stand without assistance was measured around 7′ 6″. Zech Devits was measured and labeled to be the height of 7′ 8″. Siah Khan was labelled with a height even over 11 feet tall from some sources. However his height was revealed to be around 7′ 2″ due to his extreme vertebrate curvature. 

Portrait of the World's Tallest ManFrom that source we find more information about Siah Khan…

“He clearly had a variety of medical conditions (perhaps one or more of neurofibromatosis, proteus syndrome or elephantiasis) in addition to acromegaly contributing to his physical and mental state. His hands were 117 centimeters long and his legs were 125 centimeters. Siah Khan’s skull weighed 5.7 kilograms but only had a capacity of 1,470 cubic centimeters. As a result of his complicated growth, there was no space in between the vertebrae in his vertebral column.”

“His forehead initially expanded forward and gradually also extended downwards partially covering his eyes. His chin also protruded forward in a sharp manner….. The weight of his head and skull caused him to slouch like a hunchback (without the slouching his height would have been even more).” 

It would be Roger in a subsequent post which would make me see something new. He states in a post (He is referring to a picture on the link HERE)…

“Personally, I think the resemblance between this boy affected with Proteus syndrome, and McGrory, Devits and the filipino man is impressive: big ears, protruding forehead, kyphoscoliosis, retrognatia, slim limbs, knee ankylosis, hemihypertrophy of one side of the body (hence, their sloping to one side), etc. The only feature that they do not show is the macrodactyly.” 

The first thing we notice is that the fact that these giants all had “big ears” means that there was an exaggerated, excessive amount of cartilage formation. Ears are made of cartilage how I don’t know at this time what type of cartilage the ears are made of. The protruding head reminds us of many pituitary giants with protruding heads. From the picture above on Siah Khan we see that his condition is very severe.

mandysellarsNote: A good example of just how enlarged Proteus Syndrome can make human body parts, but especially the limbs (aka appendicular skeleton areas) is the case of Mandy Sellars which is shown on the left. And NO, that picture is NOT photoshopped. Her condition is real and can show just how severe and detrimental proteus syndrome can be to the human body.

From Mandy Sellars website on the Proteus Syndrome we would find the symptoms on the condition…

What is Proteus Syndrome?

Proteus Syndrome is a condition which involves atypical growth of the bones, skin, head and a variety of other symptoms.

The name comes from the greek God Proteus who used to change his shape or form.
it is very rare, variable and progressive, affecting more males than females and the cause of is unknown.
The syndrome became more widely known when Joseph Merrick (the patient depicted in the play and movie “The Elephant Man”) had severe Proteus syndrome rather than Neurofibromatosis as had been previously suggested.

What are the signs?

1. Overgrowth, asymmetry (none symmetry) and gigantism of the limbs.

2. Increased size of an organ, or the body, or bones aka Hypertrophy

However again I would go off on a side tangent on my research and need to come back to the original forum thread. The names of a Robert Melvin would be mentioned who is well known for his puffy face who was called The Man With Two Faces. He suffering from Neurofibromatosis. (source)

Roger would make more informative comments with…

“I dont know how symmetric is the overgrowth that McGrory and the others show on his heads, but I agree that they have very specific features like those protruding temporal lines in both sides of their head, sloped foreheads, etc…”

It would seem that the forum members would find that Siah Khan had a syndrome named after him called “Ghorban-Sheikholeslami-Shafeghati Syndrome“. The issue the posters note is that of the four giants we are looking at, 3 of them are dead. Only the guy the forum labeled “tallest filipino” is apparently still alive, and if we can him to agree for a genetic analysis we might be able to diagnose from a genetic perspective what is causing this condition.

The ending is what really brings the discussion to something reasonable in science validation. Apparently a study and paper was done on the curious case of Zech Devits. The paper is entitled “A provisionally unique syndrome of macrosomia, bone overgrowth, macrocephaly, and tall stature” by  Ab Sadeghi-Nejad, and Lawrence I. Karlin. Article first published online: 18 MAR 2005

The abstract is below (Note: A full text of the paper is not available off of say PubMed but is available on the forum HERE

Abstract

We report a young man with intrauterine macrosomia, macrocephaly, and bony abnormalities. Excessive growth continued throughout infancy and childhood. Bone age was advanced. He developed contractures of the large joints and was confined to a wheelchair. Extensive laboratory studies, repeated on multiple occasions were all normal. Intellectually, he was normal. His near final height was 234 cm. The constellation of findings in this patient is at variance with previously described syndromes of tall stature. We postulate that excessive size and bone overgrowth in this young man is caused by a receptor/post-receptor abnormality involving a growth on/off mechanism at the cellular level. © 2005 Wiley-Liss, Inc.

Conclusion: This post is getting way too long so I will cut it off here and continue this new discovery in a next post. What is amazing to note is that these men all seemed to have suffered from some genetic disorder to cause them to develop extreme height. Zech was found to have a height of 234 cm which is over 7′ 8″ even though he would eventually be confined to a wheelchair, just like Matt Mcgrory. The analysis on a more scientific level will be done in the subsequent posts.