In what I would call one of the most seminal posts I have ever written for this website which is “Why Growing Taller With Closed Growth Plates Is So Difficult To Figure Out And Impossible To Almost All People” I had proposed that there is really two possible ways that we can achieve the ultimate goal of height increase if the people are truly extremely adamant on the fact that we must always be searching for a non-invasive/ minimal invasive solution or approach, which I personally don’t agree with.

The two possibilities are to either…

1. Turn a band of the bone tissue in a long bone like the femur into cartilage tissue, and then manipulate that cartilage into the right type of cartilage we want, then add the chondrocytes into the cartilage, get them to align in columns like the way natural growth plates work.
2. Somehow get the bone cells like osteoblasts to be able to expand out through hypertrophy and push against the organic & inorganic formed bone extracellular matrix and pull them apart. 

At this point, I have stated that it takes a tremendous amount of force, around 25,000-30,000 Lbs to pull the average adult human male femur steadily apart to the point where it has a chance of plastically deforming instead of snapping back in its original length due to the extremely high Young’s Modulus value.

Personally, I can’t figure out any idea or way to get the bone cells to be able to expand/ hypertrophize with enough force per area to push the matrix of the bone to a point where the entire bone structure would stretch out. I wonder just how strong in terms of the Surface Tension is the outer membrance of the osteoblasts. Can the surface of the osteoblasts, osteoclasts, and osteocytes have a high enough surface tension to be able to actually pull apart the ionic bonds that form between the calcium phophates minerals aka hydroxyapatite so that the entire matrix, environment around them is expanded out ward?

I can’t see how, and that is why I would say that at least right now, and not any time in the foreseeable can I see any type of scientific or biomedical idea or theory which can accomplish this task.

What is left is that idea of whether we can turn the bone tissue into cartilage tissue. This turns out to be the hardest step.

Like I said in the previous post, we would be going in reverse against the natural differentiation path of cells in the human body.

Natural way: Cartilage Cells Differentiate into Bone Tissue Cells or die from apoptosis leading to hollow cavities filled by bone tissue cells.

What we are trying to do: Turn Bone tissue cells into cartilage cells

The best way to figure it out would be to see how to do the process known as transdifferentiation, where one type of fully differentiated cell turns into  another type of fully differentiated cell without going through the middle path which is to de-differentiate and revert into a progenitor form of  stem cells, and then redifferentiate into the type of tissue cell we are looking for.

The fact is that researchers can already turn the cells in urine into stem cells for teeth. (source) So the technology for focusing one type of stem cell into differentiate into a fully differentiated cell like neurons, adipocytes, etc. is available already. The step on how to de-differentiate backwards into the progenitor cells has also been very well studied and there are some options.

It is just that scientists have not been able to figure out how to do transdifferentiation of fully differentiated human cells yet. If we understood at the genetic or nano level on how some animals like the Immortal Jellyfish does this process, which mRNA or microRNA is activated to turn on the expression of which gene, then we would be able to figure out how to turn the bone cells in a certain area of the body into cartilage cells. If we can keep the chondrogenic phenotype long enough through some type of minimal approach like Ultrasound, Extracorporeal Shockwaves, etc., then it would start releasing the right type of extracellular proteins and compounds like Collagen Type 2, proteoglycans, Glycoaminoglycans, Type IX, and Alkaline phosphatase, which would slowly turn the region of bone from a hard, brittle matrix into a elastic one which would eventually become hyaline cartilage.

The title of this post is “Increase Height And Grow Taller Through Cartilage Regeneration Through Stainless Steel Strength Osteogenic Tissue”

What the title of the post really means is that instead of trying to stretch out bone, which has the resistive and material strength at the same magnitude as stainless steel (source), we should try to regenerate (or actually generate) the cartilage tissue which can get in between the osteogenic tissue/bone and slowly replace the bone into something that is much less strong which we can work with.

So we can try to either get small fragments of cartilage tissue embedded in between the large much harder and stronger bone, and then figure out how to dissolve/ filter out the bone tissue over time, or we try to turn a segment of the bone into cartilage tissue, using maybe de-mineralization techniques, increasing of PTHrP levels, acid-base titration reactions, or activating some type of microRNA signals which will start the transdifferentiation process.