PEMFs(Pulsed Electric Magnetic Fields) have been implicated as having height growth potential before.
Physical Stimuli-Induced Chondrogenic Differentiation of Mesenchymal Stem Cells Using Magnetic Nanoparticles.
“Chondrogenic commitments of mesenchymal stem cells (MSCs) require 3D cellular organization. An approach is reported to drive 3D cellular organization and enhance chondrogenic commitment of bone-marrow-derived human mesenchymal stem cells (BM-hMSCs) via magnetic nanoparticle (MNP)-mediated physical stimuli. MNPs isolated from Magnetospirillum sp. AMB-1 are endocytosed by the BM-hMSCs in a highly efficient manner. MNPs-incorporated BM-hMSCs are pelleted and then subjected to static magnetic field and/or magnet-derived shear stress. Magnetic-based stimuli enhance level of sulfated glycosaminoglycan (sGAG) and collagen synthesis, and facilitate the chondrogenic differentiation of BM-hMSCs. In addition, both static magnetic field and magnet-derived shear stress applied for the chondrogenic differentiation of BM-hMSCs do not show increament of hypertrophic differentiation.”
Although stimuli applied to pellet culture is a lot different than applying it to scattered stem cells throughout the human bone.
“cellular condensation is prerequisite for chondrogenic differentiation”
“Magnetic nanoparticles (MNPs) have shown to offer a promising strategy to induce multicellular organizations. Forcing the cellular condensation via magnetic forces mimics the cellular condensation that takes places in vivo during limb development”<-maybe magnets can force the condensation in the limb.
“Physical stimuli were applied to MNP-incorporated cell pellets for 1 h for five consecutive days up to 3 weeks in chondrogenic differentiation medium.”
“MNPs themselves did not have any direct effect on chondrogenic differentiation, exogenously applied static magnetic field, and magnet-derived shear stress have probably induced closer cell–cell interactions and increased the nutrient perfusion within the pellets, respectively.”<-We couldn’t do anything with these MNPs anyways but the shear stress and magnet forces absolutely.
“The results of gross images demonstrated that the diameter of cell pellets increased when more than one of static magnetic field and magnet-derived shear stress was applied. However, there was no cellular proliferation regardless of MNPs and physical stimuli following the DNA content analysis. The ECM is osmotically swollen following the chondrogenesis progression, due to cross-linked GAG, one of the major components in chondrogenic ECM. Increment in volume of cell pellets with physical stimuli would signify their sufficient chondrogenic differentiation”
“single magnet-derived shear stress had more chondrogenic differentiation effect than single static magnetic field, and static magnetic field synergized with magnet-derived shear stress was more effective than single magnet-derived shear stress in chondrogenesis. Although the physical stimuli referred to as static magnetic field and magnet-derived shear stress needed more precise optimization, it was obvious that static magnetic field synergized with magnet-derived shear stress would be the most effective biophysical stimuli on chondrogenesis”