Monthly Archives: May 2014

More Information On Alexander Teplyashin and His Moscow Based Clinics

More Information On Alexander Teplyashin and His Moscow Based Clinics

June 1st, 2014: This is the 2nd part of a 2 post series where I explain to the readers how this Moscow based stem cell research clinic finally succeeded in getting the stem cells method to fully work. To read the original article, click here.

This is a very quick post today since I am getting more and more information on Teplyashin. I went back on the StemCellRussia.com website and found a Youtube Video which talked about this guy. I will put the video at the bottom of this post. There is a video of him answering questions in an interview and I got his russian name from the screen which I clipped and pasted to the right.

I had to use a russian/cyrillic keyboard to type out his name. (It turns out the problem I had before with finding the right character to write “x” is two characters, which is “KC”. That was why the day before I couldn’t write out his real name. This is how you spell his name.

адександр тепляшйн

Copy and paste the following name into the Russian based search engines like Yandex.com or Rambler.ru

Here are two russian sources I used (Here and Here). Use Google Chrome so that the russian based websites can be automatically translated into English to read.

TeplyashinHis Clinic Name: BEAUTY PLAZA HEALTH & SPA

Address: Russia, Moscow, ul. Kuznetsk bridge, 17, 7th floor

Or: Kuznetsk Building Street, Building 17, Building 1

He seems to have founded even a company based in New York called Stem Cell Higher Technologies Inc (which I found no information on from a quick search on Google).

Website: www.beauty-plaza.ru

Contact Numbers You can Try:

  • +7 (495) 234-57-20
  • +7 (495) 234-57-30
  • +7 (495) 234-57-40
  • +7 (495) 234-57-50
  • +7 (495) 621-11-22
  • +7 (495) 621-18-88

Email: recep@beauty-plaza.ru

PlackYou would see that this guy is a credible plastic surgeon which seems to have experience going as far back as 1985. There seems to be a lot of review websites which critique his level of surgical work. There is a lot of information on this guy. For example, he has gotten quite a few medical awards from European countries back in the 90s.

The fact is that at some point, Dr. Sanjay Gupta and Hillary Clinton have visited this guy to interview him on the stem cell research going on in Russia. There is a Russian Journalist Sergei Dorenko who wrote about Teplyashin in a book entitled “2008” He wrote about that experience in some type of autobiography called Chasing Life (I assume that is in russian). The book is even listed on sale on Amazon Here (not an affiliate link). The other way to spell this guy’s last name is Teplyashina. (This is the source I used)

PublicationsIt seems that in the Moscow scene in terms of stem cell research, this guy is sort of a famous plastic surgeon celebrity, sort of like Dr. Shahab Mahboubian based in Hollywood, who does Limb Lengthening Surgery.

His focus is on breast augmentation, breast implants, and breast lifts. There was a website called www.idealbust.ru at one time which now redirects to his primary website http://beauty-plaza.ru/ru_ideal_bust.

(Warning: Website is NOT safe for work. Includes some nudity.)

Analysis On His Research

I found out earlier today from a quick search result on Yandex more about his speciality. His focus is on plastic surgery alterations on the breasts. He is one of THOSE types of plastic surgeons. The obvious question then is whether this guy ever really did the research for bones and cartilage regeneration. Was he really involved in that research, or did he do the act of slapping his name on a project which he was not really actively involved in? We know from many USA universities, tenured professors often get their post-docs and graduate students to perform the real lab works and then take credit for it by putting their name somewhere as one of the authors.

I am quite sure that he was not the originator of the paper I had cited in the previous post. The likely real tissue engineering innovator is someone in his team, who has focused their attention on the bone/cartilage side of tissue engineering research. His focus is on extracting and growing stem cells from fat tissue. The one really well known patent he published which can be found in Google Patents refers to getting MSCs from fat. That is still relevant though, if you can get the end result of both fat and bone marrow derived stem cells to be the same.

One commenter calling themselves Tynai from Russia gave some interesting useful information which I clipped below. They are answering some questions so maybe Tynai is a marketing representative for Teplyashin’s Beauty Plaza Business. His English is hard to understand though.

Moscow Based Clinics

It seems that he answered some other questions I have had. The team that Teplyashin is head of seems to fully realize what they have achieved, and do want to take the stem cell technique to human and to the world-wide market. They intend to patent this idea. However, there is some issues still and the regulators in Russia is asking them to do more trials to prove the general concept that it would work properly.

This would kind of explain why the Moscow based clinics have been saying that they would get the tissue engineering technology ready for the general public for at least 3 years now. That was the big complaint by the guys at the Make Me Taller Forums. They heard about Teplyashin’s research, but the team did not deliver in the time they had initially claimed. They said only 1-2 years, but it has been 3-4 years past. The reason Tynai is giving suggest that there are not enough willing participants who would agree to do the preliminary clinical trials as test subjects!! The last I checked, there was at least 3-4 willing participants who wrote back in 2012 on the MMT forums that they are willing to do it. So maybe the clinic is lying. I believe that they will have a patent filed, but to actually bring it to market in even say 3-5 years time, I am not holding my breath.

(Side Note: For people who are don’t know that much about legal issues dealing with copyrights, trademarks, patents, etc. the legal process to get a patent to be properly filed often takes at least 1-2 years. I took a Bioengineering and Entrepreneurship course at the local University of Washington for fun and a huge section of the class was devoted to talking about the lengthy process it takes for universty lab based discoveries to finally become patented and taken to the general public aka market.)

The only thing for people who want the real deal in terms of an alternative to Limb Lengthening Surgery, they can only just wait, and hope that the Moscow based Clinic will roll out the less invasive surgical procedure in the next 3-5 years, which is very reasonable.

The Cost of The Stem Cells Method – Is it more expensive than LLS?

The guys at the MMT forum mentioned in their usual negative attitude that even if the surgery was available, most people who are not Russian Billionaires would not be able to get the chance to use it. I only half agree with those comments.

It will be expensive, and I would guess it would range around $100,000-$400,000 for each growth plate implant. Each implant based on how thick the cartilage is is claimed by Teplyashin in the older sources to give around 7-8 cms increased bone length each. That is very impressive. A multi-millionaire would be able to get maybe 4 implants (for their 2 femurs and 2 tibia) and gain up to 6 inches over the course of 1-2 years, while not being confined to external fixators or need to have another surgery to pull out internal nails.

However, as long as the technology and the surgical procedure is finally implemented for the commoner, even at millionaire level prices, over time, say in 5-10 years, there will be other clinics around the world (most especially in China and Plastic Surgery obsessed South Korea) which will have surgeons who learn how the procedure is done and implement it into their own skill set. Given another 10 years after the first successful surgery of growth plate implant, the price would be reduced to maybe levels around $30,000-$50,000, a full magnitude lower.

Over the Technical Issue of The Soft Tissue around the Bone Tissue like Muscle and Ligament being the constraint to limit bone lengthening…

I recently found at least 1 chemical compound (and 1 patent detailing another chemical) which have shown to be able to increase the muscle tissue fiber characteristic known as “extensibility” with just a few injections. That is actually going to be in one of the up-coming posts which will also be the next game-changing post. Stay tuned for that one. I DO NOT plan to write about the revolutionary chemical which can literally “lengthen” muscle fibers anytime this week though.

Some Closing Thoughts

There are some crazy research stuff going on in the world currently, often hidden from our eyes, and often they are not going to be something you can find from a quick Google Search. You would need to go to different countries, look in the labs of private think tanks funded by ultra-private rich investors with very personal agendas, privately funded university labs, government facilities, and military based operations. We are not aware of what is really possible because we are almost never told the whole truth. I am going to try to bring as much of the crazy research out into the open as possible for you guys to see.

The fact is that based on how explosive and fast stem cell research is going, and multiple university professors trying to find ways to regenerate hyaline cartilage, what Teplyashin’s team did is not really revolutionary. They are only the group that put the entire thing together and was willing to take the general concept of stem cells and tissue engineering to work for the purpose of helping adults with fully ossified growth plates grow taller. If they didn’t do it, someone else or another research team would have done it within the next 2 decades. All the real technical barriers have been overcome. I proved that after going through hundreds of PubMed studies on tissue engineering. The problem on how fast stem cell research can progress and be brought to the general public for use has been held back for USA government laws passed against lab work done on unborn embryos. That has actually held the stem cell field back for the last 2 decades. Only this decade did the government officials realize that one can get stem cells from other places besides just unborn fetuses and embryos. That is why the research have finally started to pick up again and this field is super-hot to get into right now.

To end this post, I would like to quote a passage from Hamlet, “There are more things in heaven and earth, Horatio, Than are dreamt of in your philosophy”

I put a video below which was uploaded back in 2008. It shows Teplyashin giving an interview, all in Russian.

Him on a radio station to talk about the trends of plastic surgery for rich women in Moscow getting so much plastic surgery.

Why I Believe Alexander Teplyashin Got The Stem Cell Technique To Successfully Work – Game Changing Post!

Why I Believe Alexander Teplyashin Got The Stem Cell Technique To Successfully Work – Game Changing Post!

Update June 1st, 2014: This is the 1st of a two post series where I reveal in detail how this Russian based beauty clinic doing testing on stem cells finally put all the pieces of tissue engineering together to get an implanted stem cell embedded scaffold to turn into a new growth plate which is re-implanted into a bone to get bones to grow longer again. For more information on the actual clinic and the scientific references of the main surgeon, refer also to the 2nd post in the series, Available Here.

Guys, this is one of the big news I am going to release in the coming months. This is just ONE of the many game changers you guys are going to be seeing.  This is one of the major stories that is worth releasing. You guys can look forward to a real alternative to LLS.

This week, I have gotten messages from two people questioning the stem cell technique of height increase which was claimed to be successful by the Russian Scientist Alexander Teplyashin. I wrote about this guy already in two posts linking his work to stem cells used for increasing height in adults.

While one of them ask whether the technique was effective, the other claimed that they believe that he was successful. Based on my research, I agree with him. This post is one of the biggest things to ever come out, and I think we need to accept the implications of such news. There may be a scientific push in innovation, but it is going to be associated with some serious medical ethics questions, dealing with the use of embryo derived stem cells, which is currently still illegal in the USA.

This Teplyashin guy probably did succeed with getting a stem cell scaffold implant to work. The problem is that this very controversial guy who was back in 2008-2010 getting a lot of international media coverage. In recent years the western world and the internet hasn’t gotten any information on him. I was able to find articles on this guy going as far back as the 2004-2005 time range.

The Make Me Taller forum had people talking about him back in 2012 in their thread “Russian scientists develop an alternative way of growing taller using step cells“. They thought it was a scam. It is NOT a scam. This guy is the real deal. You can just read the main link I put below in the PubMed study and you guys would realize that he was going the right type of research. That study was one of the “secret files” which I have archived in my research folder which I realized more than a year ago showed revolutionary implications to our goal. The thing is that I didn’t recognize or see the name of one of the authors on the top of it. The reason I didn’t see it was because the guy’s name was spelled differently, to “Tepliashin AS“, not the other way to spell it ‘Teplyashin“. His middle name probably starts with the letter S.

Side Note: The guy also claims to also have figured out how to use the stem cells to stop aging and give people youth but I think he is most likely exaggerating. However, there is one PubMed studies which was published by him and his team to show that they are quite serious at least on the research, at least partially (PubMed Study: Ways of reducing mortality following the surgical treatment of peptic ulcer in advanced middle aged and elderly patients – Note: The paper is in russian.)

If you guys want to do some searching on this guy type in “Teplyashin, AS” or “Tepliashin AS” into Google, Google Scholar, or Google Patents and you would find quite a bit of stuff on the guy. Remember that when one language is translated into another language, there can be various spelling variations to the name. Teplyashin and Tepliashin is the English/Romanic Language way of translating the Russian/Cyrilic Alphabet. (This is what would happen when the European and Asian immigrants would arrive in Ellis Island and Angel Island in the 19th century and the officer checking them in to their new home could neither pronounce their names or spell their names in their native tongue. aka Lost In Translation. They gave these immigrants a badly translated into english name, which would be spelled in multiple various ways)  If we were using a Russian/Cyrilic based biomedical scientific study & journal database, we would be able to type in his real name using the native letters. I studied a little bit of Russian in school so I understand at least how to pronounce the letters.

Here are about half a dozen PubMed studies I found which show that his team has been doing some SERIOUS research on exactly the right type of area to get the stem cell technique to work out.

What I have been proposing for an alternative to limb lengthening surgery on this website the last full year using tissue engineering and stem cells have already been done by these guys in Russia, maybe even as far back as 2009-2011. They figured out how to get the mesenchymal stem cells from either the bone marrow or fat tissue (aka adipocyte derived) or both sources to differentiate successfully to chondrocytes. They implanted it to a scaffold, which I have believed for a few months now the easiest to work with was the OPLA Scaffolds, which is industry standard for use with stem cells. When the differentiated chondrocytes start to excrete waste in the form of proteoglycans and other glycoaminoglycans forming the extracellular matrix of a completely new hyaline cartilage tissue layer, the scaffold which is biodegradable would just dissolve over time, leaving the cartilage. That is the new growth plate. Since the MSCs are taken from the patients own body aka endogenously, there is not going to be some type of immunological response where the patients body’s immune system would reject the implantation.

So does that mean that his clinics can indeed help adults who have fully closed growth plates grow taller?

Yes. His method of using stem cells is a real alternative to the limb lengthening method done by Dror Paley, Betz, and their proteges and students.

Limb Lengthening Surgery is no longer the only way to grow taller as an adult. This guy and his team has provided an alternative.

How can I be sure that he did succeed already?

Based on the following study published…

Guys, read the abstract to the link above. That is enough to tell you guys everything. This guy is for real, and he has the scientific team and experience to back up at least this claim about using scaffold implants.

For that study it was done on lab mice/rats but there seems to have been a lot of subsequent testing on mammals much closer in size to humans. (Here is the original source) The sources which talked about using the same technology on human bones said that the testing was done on sheep so this is not a normal lab test using small mammals like rats or rabbits. They used sheep. Sheep have long bones similar in shape and thickness as human leg bones. Sure, it might have been better if the lab animals were pigs, since pigs have almost the exact same physiology as humans, but regrowth of long bones longitudinally in sheep is very close. The study is quite conclusive in my opinion.

The following study is almost the exact same type of research that Warren Grayson from John’s Hopkins (with his 3-D Bioprinters) and Jean Welter of Case Western University (LinkedIn profile available here) have been doing, but he just took it to the next step. I have been tracking the research being done by Grayson and Welter for over half a year now and even wrote a post about Grayson’s work in relation to what we are trying to do. It is available in the post “Why Warren Grayson’s Research Will Be Revolutionary For Height Increasing Using Stem Cells For Tissue Reconstructive Engineering – Breakthrough!”

The paper above proves that he succeeded in regrowing a working hyaline growth plate and implanted back in lab sheep and the legs started to grow longer again. When the results showed effectiveness, he set up shop to give the stem cell height increase technology to billionaire russians and their spouses. Maybe that New Jersey Net’s Russian Billionaire Owner used this guy’s technique to become 6′ 8″. Of course, maybe he didn’t and was always that tall.

Whereas in the USA, there are so many regulations by medical societies to make sure the patients of clinical trials are safe and protected, in places like Russia, China, South Korea, and the former Soviet Union they don’t seem to care. I am not sure if the people remember but there was a very famous South Korea researcher linked to Seoul National University who was found to have faked many data points back in the 2009-2011, a Dr. Hwang Woo Suk. Even the countries which are supposed to be good in terms of following scientific guidelines like Korea have failed too. These guys based in Russia, they push forward on the research where the other countries draw a line in ethics and morals. (It is similar to how Gavriil Ilizarov spent 30 years of his life to perfect the external frame method before unveiling his distraction osteogenesis technique to the western world during the end of the cold war era in the late 80s and early 90s. These guys didn’t give a crap about moral rules and just pushed forwards into research.)

Like I said before in the previous post on this guy, there were stories of barrels of dead aborted fetuses found in the Ural Mountain Range region linked to Teplyashin back in the 2004-2006 time from one source I found on this guy. It is very clear that he and the Russian researchers don’t give a crap about the rules imposed by the western world and USA especially. The use of using embryonic source derived stem cells is illegal in the USA and western countries. That is why many stem cell users go to Mexico and certain South American countries to get stem cells injections.

However, I am not sure who would be willing to go to Moscow to take a look at the clinics thought. Which regular readers of this website is really willing to find the beauty clinics in Moscow and report back to us on what they find?

As for the internet sources….

However, there is no news that is coming out of Russia on his Beauty Plaza clinic that can be found on Google, DuckDuckGo, or Bing. If we instead maybe used Yandex and Rambler, and could actually type out his real name, there would be some useful information on this guy.

I am willing to give it a shot though. Refer to Romanic-Cyrillic Alphabet Phonetic Translator chart below.

TranslatorTranslator 2So    A-L-E-X-A-N-D-E-R       T-E-P-L-Y-A-S-H-I-N —–> is most likely going to require that we first go under the General Settings of our computer (Mac or PC), change the general language setting to “Russian” and then type the following into Yandex or Rambler based on English Keyboard–>Russian Keyboard Key Positions. It would start with something like “F-G-L-” I am not sure what the “X” would translate into for the English based keyboard though.

Like I said before in the recent posts, We ask help from the regular readers to translate many studies we have found in other languages, most especially Russian, Chinese, Korean, and German. There is also some Japanese and Farsi based studies but there will be less of those around.

I am willing to pay $100 for the full PDF to the study above but I ask for someone to help out to translate the bought article from Russian to English.

If you have gotten this far in the post, be sure to continue to read more on the details of the revolutionary stem cell technique in the 2nd post of this series. Click Here to read more.

Korean Plastic Surgeons Performing O Shaped Leg Curvature Correction Surgery For Genu Varum aka Bow Leggedness

Korean Plastic Surgeons Performing O Shaped Leg Curvature Correction Surgery For Genu Varum aka Bow Leggedness

O Shaped Leg Curvature Correction

Due to the nature of the website and research we look at, we see all sort of interesting cosmetic surgical procedures. This new one which the commenter William called “O Shaped Leg Surgery” is something which I forgot to mention on this website. It is something many people indeed go through to remodel their very bones to the shape that they desire.

So what is O Shaped Leg Surgery?

It turns that that there is this orthopedic condition medically called Genu Varum which is commonly known as Bow Legs or Bow Leggedness. Sometimes the condition can be confused with another type known as Blount’s Disease. The leg bones are curved into a “bow” shape. The curvature is usually most visibile in young kids who are toddlers, still going through massive growth. For most people, that curvature visible when they are young kids starts to go away as they reach their teenage years. Some kids though have very pronounced curvature.

imagesIt seems that if the kid who has Genu Varum is young enough, using a band and splint to slowly bend the leg bones would be enough. However, if the kid is too old, then surgery will be needed to correct for the curvature. The tibia or fibula would be cut and then bent. We found this before and after picture. Notice how what is considered attractive is where the legs go direct downwards. The legs which are bowed would create the “o” shape in the space between the legs.

The cosmetic surgical procedure corrects for the bending of the leg bones to make the legs look straight. I am guessing that from the legs being made straighter, they are also longer after the surgery. The result is that the person gains maybe 1-2 extra centimeters of height from the procedure.

So what is mentioned by the commenter is that after the surgery, the patients only need about a single week of recovery. How that is possible and how bones can be snapped into the straight shape is something I haven’t been able to figure out yet.

Bow Leggedness Correction DeviceApparently now there are even products being sold on Amazon to correct for bow leggedness. Refer to here to see what the non-surgical strap device looks like (Not an affiliate link).

For me, products like this leg strap is something which I will never understand why a person would want to use. Is the angled nature of the legs really that big of a problem?

I remember once going to see a local Orthopedic specialist in Seattle who happened to be Japanese himself. I asked him whether I was bow legged and he replied that for most people, there will be some slight bit of bone curvature. Bone curvature is normal. Having that perfect O Shaped Legs where the knees are not supposed to touch is actually uncommon.

This seems to be a real, serious problem which affects millions of young kids causing them to have abnormal walking gaits and slight deformed legs. If the surgery is done, the developing child would expect to not only have their medical condition resolved but also end up maybe a few centimeters taller.

Side Note:

The fact is that during my almost 2 years stay in living in the Gangnam area of Seoul, South Korea I remember seeing these huge posters in the subway stations of the Gangnam-Gu area like Apgujeong, Sinsa, and Gangnam. There are before and after pictures showing the lower legs of a young girl or men who has a slight bit of bow leggedness with the eyes blacked out from getting the surgery.

When you turn on the TV in Seoul or go to the movies in the previews, you are blasted with advertisement by half a dozen large plastic surgery clinics promoting the benefits of going under the knife to “improve” one’s appearance. It is so epidemic in Gangnam that I started to believe the advertisement after a certain point.

Korea Beauty ObsessionI took the time to clip a post written back in Oct of 2012 on another website about how the mother of an elementary school girl took her daughter to get surgery to become taller. The daughter was supposed to be put through some type of stretching machine. (Source)

It is totally possible that the reason I have become so accepting of the idea of limb lengthening surgery and other bone cutting surgery to alter one’s body shape is due to the fact that I was an expat living in the Plastic Surgery Capital of the world for a little too long. My own personal perception of what is considered ethically acceptable about cosmetic alterations has become skewed from seeing so many people walk past me in the last 2 years with changed appearances.

I don’t advocate doing surgery for everything but for this medical condition, I think it is worth looking into getting surgery.

Comparison of arthritis fingers to my finger results with LSJL

Here’s the pictures of my fingers(you can follow the link on the page to get more images).  I’ve been loading the right index finger with LSJL.

Here’s an image of osteoarthritis fingers:

osteoarthritis fingersIn contrast to heberden’s nodes my fingers are enlarged at the sides and there is no fusiform swelling of the joints.  Fusiform swelling is ” elongated and tapering at both ends; spindle-shaped  ”

“Heberden’s nodes are hard or bony swellings that can develop in the distal interphalangeal joints (DIP) (the joints closest to the end of the fingers and toes). They are a sign of osteoarthritis and are caused by formation of osteophytes (calcific spurs) of the articular (joint) cartilage in response to repeated trauma at the joint.

Heberden’s nodes typically develop in middle age, beginning either with a chronic swelling of the affected joints or the sudden painful onset of redness, numbness, and loss of manual dexterity. This initial inflammation and pain eventually subsides, and the patient is left with a permanent bony outgrowth that often skews the fingertip sideways. Bouchard’s nodes may also be present; these are similar bony growths in the proximal interphalangeal (PIP) joints (middle joints of the fingers), and are also associated with osteoarthritis.”

The question is, is my enlargement of the epiphysis of the fingers an osteophyte or is it a result of endochondral ossification.  Although there are lateral osteophytes.

Heberden’s and Bouchard’s nodes

Osteophyte nodes may be painless so lack of pain in my fingers is not an indication that is not an osteophyte.

“The osteophytes beneath the lateral nodes arise lateral to the extensor tendon, and although the soft tissues have been distorted by the embalming process and have to be interpreted with caution, it appears that the adjacent capsule is displaced and attenuated.”

Here’s an image of a growing osteophyte:

growing osteophyteAnd admittedly this does appear to be like enlargement of the epiphysis.

“The true osteophyte, initially a chondrophyte, is intra-articular, developing from the synovium covered surface at the cartilage margin, either from metaplasia of existing synoviocytes or differentiation of precursor cells. The chondral hyperplasia that initiates it is not intrinsically vectored to grow in any particular direction, and in practice grows in the direction of least resistance, to an extent determined by that resistance. If the adjacent cartilage surface is unloaded as a consequence of subluxation or underuse, the osteophyte will grow centripetally over the cartilage surface. More usually it grows peripherally, forming a large pedunculated osteophyte if unopposed, as in the synovial recess of the shoulder joint. Where growth is constrained by strong capsules, as in the lateral ankle, by adjacent ligaments as at the tibial spine, or by tendon insertions as in the upper humerus, growth is inhibited and the osteophyte is small. In essence it will grow until the tension induced in the stretched soft tissues matches that induced by the growing osteophyte. It follows from these known growth characteristics of osteophytes that the regular location of osteophytic nodes at specific sites in these two joints must reflect a local area of low resistance to osteophyte growth unique to these joints. ”

Here’s another image that better shows lateral nodes:

osteoarthritis nodes

Here’s what an osteophyte looks like directly on the bone:

osteophyte on the bone

Now here’s another image of my loaded finger so you can see any potential osteophyte nodes:

20140529_132338Definitely node like.  I can’t see any evidence of swelling though.  I’ve seen young people report getting finger nudes at like age 14 so arthritis may cause nodes but arthritis may not be the only source of nodes.  And most evidence suggests that nodes aren’t painful and don’t limit mobility of the finger.

I couldn’t find any evidence upon searching that these nodes increase finger length although admittedly it is incredibly hard to use a search to find anything so that does not guarantee that there are not some anecdotal reports that people got longer fingers due to nodes.

So I conclude:  LSJL caused increase in bone length and osteophytes and these two effects may be independent.  I am using as much load as I can to get more finger results this may be overload and what is causing osteophytes.  However, less load may be possible to increase finger length without causing osteophytes.  I increased arm length with no evidence of osteophytes(unfortunately I did not document this).

This Easy To Find Over-The-Counter Supplement Pill Can Help Children Grow Taller

This Easy To Find Over-The-Counter Supplement Pill Can Help Children Grow Taller

Over-The-Counter Supplement Pill(Update 6/2/2014: I have had to add this disclaimer in the front after I finished talking to a representative who have been selling Collagen Type I and Type III extract based drinks for a beauty products company. I looked deeper into the scientific basis of the company’s claims and after realizing that their claims are unjustified by the science, I wondered whether my claims here was also unjustified based on jumping to conclusions too quickly. I think I did just that. After looking at more of the research on the efficacy of Collagen Type I extract (or based on this post, Calcium L-Threonate which can increase Collagen Type I expression) on chondrocyte proliferation, I do NOT think this pill will help adults with fully closed ossified growth plate increase in height, even minimally. However, I will stand by the claim that there will be some effect on children with intact epiphyseal hyaline cartilage. I was wrong and I made a mistake in the analysis, in jumping to the wrong conclusion. Refer to the study “Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture“.)

In the last post I had written that there was something I found which came as close to the real solution as it gets. The following post is NOT it, but something else that we should consider adding to the supplement cocktail. It is still a useful supplement to take, and has been shown to help young children avoid diseases that can be caused by low bone mineral density. What I am claiming is a very easy to obtain pill which would have quite noticeable effects with children who still have the ability to continue to grow in height, but it would also have some height increasing benefits inside adults as well. If we combined this easy to get over-the-counter supplement pill with the others that we have already researched and had found to be effective, it would only improve on the effectiveness of the overall pill cocktail. From the notes by other researchers, it seems to be safe to take orally.

I had said before in a previous post about how there is close to nothing left to talk about and nothing else to discover. That is actually true, at least when it comes to all English based sources. However, there are still some resources which have been written in the old Soviet Union in Russian, Chinese, and Germany articles which I have not been able to take a look at yet. This post is the direct result of research done in some lab in China. It is a good indicator that we need to figure out how to find resources written in other languages from other countries which have a good history of scientific research and documenting down their research. I can’t read any of the Russia, German, or Chinese based studies so we would ask that the readers who can to help us out in looking up scientific articles written in other languages.

There is in fact one study Tyler showed me a year ago from a Iranian/Persian group of doctors written in Farsi where a teenage boy managed to get his growth plates reopened or unfused due to a sports injury where the ankle was fractured. We tried for hours to get the Google Translator and Yahoo’s Babel Fish to translate it but neighter of them worked well enough for use to read.

Example: It was only through luck that I managed to track down the actual patent # that proved that the Japanese Ginza Kojima Height Increasing Machine was indeed real and legitimate, based on a real patent. (Click Here to see the pictures of the actual patent.) Their method on increasing a fully grown person’s height using minimally invasive methods is completely original and makes total sense from a physics perspective (Using a combination of centripetal force and IVD decompression). Like all good things though, even that Patent has its limits on what it can give a person in terms of height. But the Japanese based patent was real and was shown to be reasonably effective, as judged by me and Sky more than 6 years ago.

What did I actually find? There is a certain compound which seems to have the effect of increasing the thickness of both articular cartilage and epiphyseal cartilage by increasing the expression of Collagen Type I.

The source is from a patent I discovered in the Google Patent Database entitled “Calcium l-threonate for preventing or treating cartilage related diseases (Patent # EP 1458372 A1)“. These patents are often filed to various international organizations to not just cover the intellectual rights of the use of the patent in one country but in many countries. The other Patent # is WO 2003004012 A1

So what is this compound? Calcium L-Threonate

Bio-Calth Calcium L-ThreonateFor this patent, I did do a rather extensive analysis on it to see whether what they are claiming was accurate. Was I just reading too much into this patent and looking for validation on what I hoped was in it? Probably, but sometimes we have to make connections that are very weak. I believe that there is a positive correlation and a causal effect, but it is very weak.

You can get the L-Threonate from Here.

Chemical Properties:

Calcium L-Threonate Chemical CompoundComes in white powder form, has no odor, is soluble in water but not in alcohol based liquids. Written as C8H14O10Ca. 

From the Patent, they say that the compound can be made from first combining L-Ascorbic Acid with Water, and then adding Calcium Carbonate into the mixture. Hydrogen Peroxide was added to start the Acid-Base reaction, at a set temperature up to a certain time. Push the product from the chemical reaction through packed active charcoal to filter and do a chemical separations process

Is the compound safe?

It seems that the L-Threonate compared to other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) like Ibuprofen used to treat cartilage inflammation has less side effects. So it is safer than commonly prescribed prescription drugs. This might explain why the FDA allowed the compound to be allowed to be OTC or Over-The-Counter.

Dosage Requirements:

  • For an adult is typically between 0.5 g and 12 g per day, preferably between 3 g and 7 g per day. (Note: After doing some calculations, we found that for a person who weighs 150 lbs, they would need about 7 grams per day)
  • For children, the dosage may be decreased according to their weights

So What Is The Scientific Basis For Its Effectiveness?

The patent states that the Calcium L-threonate would have effects on collagen type I mRNA expression as well as a host of effects which I will just quote from below. (It has effects on articular cartilage, epipihyseal cartilage, chondrocyte hypertrophy, cartilage matrix generation, proteoglycan synthesis)

From the abstract…

“….It had been demonstrated by experiments that calcium L-threonate could improve significantly the positive expression percentage of collagen I mRNA in the chondrocyte and osteoblast, improved significantly the positive expression percentage of articular cartilage and epiphyseal cartilage, facilitated the growth of chondrocyte, increased the quantity of bone collagen, promoted the formation of bone and cartilage matrix and the synthesis of proteoglycan…”

Important: Now, we fully realize that the actual type of collagen found in hyaline cartilage and the epiphyseal cartilage is collagen type II. This compound would only increase Type I expression. Type I is actually the really, REALLY common type which is found in the human body. It is the same type as what women pay plastic surgeons to inject into their lips.

In the experiment the researchers took a total of 66 young lab rats and injected them with retinoic acid, which is a very well known compound which causes bone density loss and cartilage proteoglycan degeneration. 8 of those rats were use in a control group while the other 58 rats were put into 9 groups. Of the 9 groups, the chemical compound of normal saline, Caltrate-D, Calcium Citrate, Sodium hydroxyethyl phosphate, Calcium Citrate at 50 mg/kg of body weight, Calcium Citrate at 100 mg/kg of body weight, and 200 mg/kg of body weight.

The drugs were given to all groups except control for 10 weeks and fed a low Ca diet. After 10 weeks, the lower part of the right femur of each rat was extracted and analyzed.

Immunohistochemical stainingTo see the changes, there were immunohistological chemical assaying done using a chemical staining kit. If there was an increase in Collagen Type I expression, the bone and cartilage area would turn into a color of brown-yellow. The results can be seen in the Collagen Type I mRNA Expression of all 8 (wasn’t there supposed to be 9 groups??) sets. This is for the data from the immunohistochemical staining.

We note the difference between the Caltrate-D group and the Calcium L-Threonate group. Caltrate-D is just a brand name for a type of calcium supplement with very high levels of Vitamin D. When the rats were given caltrate-d, the chondrocytes actually started to ossify. Compare this to the Calcium L-Threonate,

For the group who got the Sodium hydroxyethyl phosphate, the chondrocytes did proliferate, but the chondrocytes seemed to be disorganized and started to clump together into osteoid groups (Bad sign).

It seems that for the 3 groups getting the Calcium L-Threonate, the effect “was helpful to the growth and development of epiphyseal cartilage and improved the process of autoskeleton in epiphyseal cartilage“

Is the height gains permanent?

Unlike so many other techniques that have come out, the gains would be permanent, at least until the adult grow old and reaches their 50-60s and start to shrink again due to decreased collagen and proteoglycan levels in the IVDs. This is as permanent as it gets.

Why would the gains be permanent?

That is due to the fact that Calcium L-Threonate has more than just an effect on bones, or cartilage specifically, but both of them at the same time. The effect on bone is most pronounced. It increased the micro-circulation within the bones and reversed bone mineral density loss. This patent stated explicitly that

So what do you guys need to take away?

What the patent is actually doing is to claim an alternative, rather simple approach on making the Calcium L-Threonate. You’d need Ascorbic Acid, Hydrogen peroxide, Calcium Carbonate and water. as well as a heater of some kind. Of course, who would want to do that and put a chemical lab in their room?

The Chinese researchers tested 9 groups of lab rats and let them eat the chemicals. The leg bone of the rat was cut out after 10 weeks and tested to see how the difference in collagen expression and bone tissue accumulation and changes. The group with the L-Threonate had the biggest changes.

The patent states clearly that the supplement will be useful in treating and preventing cartilage-related diseases. Using a dosage of around 50-200 mg per kg of body weight would mean that the average 150 lb human would need about 7 grams of the compound for each dosage.

This compound would increase the level of Collagen Type I in the body in both children and adults. For children, it would have very noticeable effects, if one could ever do a real controlled type of scientific height increase test using identical twins. However, I don’t believe that type of experiment has ever been done.

For adults, the effect will be minimal, but for a certain minority of the adult population, it would actually let them increase in height, by upwards of a few millimeters. But you would want to combine it with other supplements we have already mentioned before. It will work best in a group.

Here is a link to Amazon where you can buy it if you want

Bio-Calth Calcium L-ThreonatePrice: Currently $25 on Amazon with Free Shipping if your order is over $35.

(Yes, it is an affiliate link. We get about $1 for every purchase the person makes through it.)

Note: The picture to the right is for the supplement sold by the reseller company BioCalth. On the product box right on the front, they actually directly reference two patent #s. They are….

  • Patent # 6077872 – This patent showed that Calcium L-Threonate can treat rickets in young kids. – Link Here
  • Patent # 6713513 B2 – This patent is the one we just talked about. – Link Here

It seems that the people from BioCalth specifically created and sold this supplement because they became aware of this China-based patent and saw a small market for people who wanted it.

 

Thoughts From One Of The Female Readers On Why She Wants To Be Taller

Thoughts From One Of The Female Readers On Why She Wants To Be Taller

Since the website started, I’ve gotten messages from dozens of people who have written their entire life story on how they dealt with the insecurity of feeling smaller than others. Most of them have been from young teenager men, who compare themselves to their school peers and wish to be more attractive to the female gender. However, there are also a few females who have messaged me.

This message was left by a person who calls herself “Z**” months ago.

Submitted on 2014/03/08 at 9:24 am

This was an interesting post. i can relate to the retired man who never gave up on his quest to be taller. Though I am a female, 30, i too never gave up. My obsession with being taller began around 15 or 16 when i wanted to be a model. I had been wearing about 2.5″ lifts from that age until I was about 22 until my foot started to hurt and wearing lifts were so inconvenient. They were hard to walk on and I could never go to someone’s home or do anythign that required me to take my shoes off or it would “expose” me. People who knew me then that i havent seen still think that I am really 5’7″.

For some girls, they move on and get over it, but i was really obssessed and never stopped wanting to be a model even now, when I am well past the age of when typical models are “discovered”. Ive also wanted to be taller because I think taller makes you stand out. I stand at 5’4, if i stand super straight then maybe about an extra half inch. I wear one inch lifts out, and to be honest, I dont feel that i am very short. I usually feel on the small side to average side however i think now, though i have not fully accepted my height still, i am also much more comfortabel with it. Anytimne i meet other people , i size them up by their height and see how much taller or shorter i am in comparison. I never leave the house without about an inch to one and a half inch in lifts, which is honestly hardly a difference when you take your shoes off. I think it is more of a mental thing where it just makes me feel better. Well, basically my point is, yes there are people who have never been able to let go of this, and after 15 years, i still search that there is hope that i can gain a few more inches.

My reply

Z**,

I wanted to ask this question to a female, since height issues effect mainly men. How or why did this issue manifest for you? Was it from some insecurity issue from a younger age or something? Being 5′ 4″ is actually quite average for height. 

(Notice how she mentions that she is 5′ 4″ which is actually quite average for american females.)

Her Next Message to Me…

Hello,

I just noticed your email today! Sure, I’d love to give you a response to your questions.

How or why did this issue manifest for me?

I think it started when I was around 14, I just had this obsession of wanting to be a model, and models are tall (5’8 +). I remember in high school admiring all the tall girls and thinking how I wished I could be just like them. I also associated being tall with just being better than others for some reason. i thought that you stand out more, you are prettier, glamorous etc. I never stopped wanting to be a model, even now when it is quite unattainable at my age. I think this has caused an insecurity that just never left me, and I am 30 now. I started wearing lifts in high school and by the time I was in college my lifts were as high as 2.5″-3″. No one has ever known that I wore lifts. It affected all aspects of my life, from being in social situations to personal relationships to doing any activities and figuring out which shoes to wear going through airport security is always a nightmare haha. As a result, I think I became even more introverted as i would have to avoid certain situations that required shoes to be taken off. I previously traveled and lived in T***** recently and was there for 4 years. During this time, I started to wear lower lifts because it just became impractical with all the walking and traveling. I think this helped me too to accept my height a little more. I was quite surprised by the height disparity there.

Tall girls (around 5’7) are just as common as very short girls( under 5’2 or so). In fact, I found people around the 5’4-5’5 range to be less common.

Thank you for saying that 5’4 is actually quite average for a girl’s height, but I do feel like a shrimp often, especially I notice caucasion women are often a bit taller. Well, sometimes I also notice that I am taller than most of the other girls in a room. Like i said in my previous email as well, I have somewhat accepted my height, somewhat. At least, I am more comfortable with my height, though I never leave the door without at least 1″ lifts, which is sometimes ridiculous as I don’t think it makes much of a difference, but I think it just makes me feel better knowing that there is something in my shoes.

I also know it is rare that height complexes usually affect men not women. It has greatly affected me and caused me to be super insecure and I missed out on many opportunities throughout life. Ive obsessed about it since the age I was 14. I had tried many experiments to see if I could gain a few inches including hanging upside down and sitting with weights. All failed. Again, it is much better now, though I still care and probably always will try and do anything to gain even an extra inch. I wish I could tell other people to not obsess about their height, it is just not worth it. Just go live your life to its fullest, but I suppose it is a mental thing and  it is easier said than done.

Please let me know if you have any other questions, I am happy to share my experience especially if it can help others!

Regards,

Z**

I asked her for permission to publish her messages and she agreed, on the condition that I change her name and the names of places she has visited. I complied on that wish.

Based on the way she compared herself to “caucasian” women I would assume maybe she is not caucasian, and maybe african american or east asian or south asian or hispanic in race/ethnicity. Race does play a difference in how she views herself. Based on averages of different sub-set of human groups, if she is a hispanic or asian female, being 5′ 4″ would definitely make her NOT short.

She seems to have lived abroad in another country for a few years and the differences of the height in the two countries might have given her another perspective, and maybe even made her feel more accepting of how tall she is. She admits that now she doesn’t try to wear shoes with too high of a heel.

We are very happy that she has managed to get her internal demons exorcised a little bit. If she still feels like she will always need that extra 1 inch of height to give her a little more confidence in social situations, then more power to her. As long as she is not hurting anyone else or herself from her habits and behavior, we will always support her on what she does.