I am happy to inform height increase seekers that I might have found one of the first compounds one can take (orally or through injection) which has the potential to lead to increased growth rate and final height for people with open and closed growth plates.

This is only the first in a long list of posts which I will probably do on this new compound i have discovered which seems to have potential which I have never believed was possible before.

Recently I found through the tracking of traffic software I have installed to this website a backlink from a website that is written in the language of Swedish. I was not able to read the swedish words but having Google Chrome as a browser made everything so much easier. Either chrome allowed me to automatically choose the option to translate the page in swedish to english or I right clicked (which is putting two fingers down using a mac osx) on the page screen and clicked the option to translate.

The website link is http://y4ser.wordpress.com/2013/04/06/benens-langdtillvaxt/ . It would seem that many people around the world write about genetics, evolution and how human sex size differences determine mating privileges or preferences. In one of the April 6 posts, one paragraph I found which was translated talked about a chemical compound called Flurbiprofen…

“Flurbiprofen, a compound once thought to aid in easing arthritis pain, has been tested on growing rats. It produces EXPLOSIVE radial bone growth, some rats bones growing by almost 30-40%! And even in the older rats, BMD has increased by 200% in these trials. It even makes the bones grow longer in growing rats (height increase)!

The Holy Grail to bone growth? That’s for us to test, since we are humans rather than rats.

The best part is Flurbiprofen is legal, and doesn’t shrink your nuts while on a cycle of it! Woohoo!

I would feel much safer for my endocrine system development on this!

Sorry if I am jumping the gun on this, I’m just so excited I found these trials!

Opinions?”

The poster would link two scientific articles showing that the chemical compound has an effect on young and old rats/mice.

One is from PubMed: Flurbiprofen enhances growth and cancellous and cortical bone accumulation in rapidly growing long bones. (Abstract below)

The other link he cited was from Science Direct but I would guess that the article he cited can be also found from PubMed, and that the name of the article is “Flurbiprofen-induced stimulation of periosteal bone formation and inhibition of bone resorption in older rats.” (Abstract below)

If you are a serious height increase researcher, I would STRONGLY suggest you read and look over these articles!

Two other articles I found which shows that this compound seems to have even more osteoblast effects.

• Alfacalcidol-stimulated focal bone formation on the cancellous surface and increased bone formation on the periosteal surface of the lumbar vertebrae of adult female rats.

• Alfacalcidol prevents age-related bone loss and causes an atypical pattern of bone formation in aged male rats.

There is one major caution which I have to raise up before we go too crazy on the miraculous powers of flurbiprofen just yet. The thing is that even in adult rats, their epiphyseal growth plates never fully go away, but that the cartilage does not completely turn into bone. So even if we are talking about aged, old rats/mice, we must always keep in mind that the scientific experiments done on them can not be directly translated into results that would be the same in humans if humans were the test subjects. So let’s move to the analysis & Interpretation…

Analysis & Interpretation:

From the first study, it seems that the flurbiprofen may have some miraculous bone growth abilities. Not only can it increase the radial thickness of the long bones, it can even stimulate increased longitudinal growth which definitely what we are curious about. However the first study was done on extremely young rats with clearly open large growth plates that can be manipulated. The fact that even the growth plate increased in thickness and that the periosteal layer increased in the appositional growth rate shows that this compound may require much more analysis to see whether it has any possible potential.

The fact that the flurbiprofen is a a non-steroidal anti-inflammatory drug, NSAID seems reasonable. The cortical bone increased in bone density around 15% while the increase in the cancellous bone was around 90%.

The increase in cortical bone is because of the increase in periosteal layer formation but no increased in the size or diameter of the intermedullary cavity. The increase in trabecular/cancellous bone is from the decrease of osteoclasts which are supposed to help induce resorption of bone into the blood stream while not increasing the osteoblast numbers.

The researchers for the first study concluded about flurbiprofen with…

“…the conclusion that flurbiprofen, induced changes in rapidly growing long bones by reducing osteoclast activity and recruitment, stimulating longitudinal and radial growth, increasing the cortical bone mass by stimulated periosteal bone growth and depressed endosteal resorption, and increasing cancellous bone mass by depressed trabecular bone resorption without affecting bone formation”

However it seems that the 2nd study would pull the exuberance by height increase seekers back down since the results are much more sedated. In what are known as 9 month old retired rats, the experiments were done on. If we are to use the term “retired” more liberally, can we assume that the rats were old enough to be considered to have reached physical maturity so that they had not more growth plate cartilage anymore?

I think not.

However the subcutaneous injections of flurbiprofen shows that for the old rat, the long bones did not get any longer, but got thicker where the radial increase was up by 200%. It seems that in the tibial shaft, the increases are due to the fact that the flurbiprofen can decrease the number of osteoclasts leading to increased calcification. Mineral bone formation rate and mineral appositional rate increased. The researchers noted that the bone formation increases seen in the older mice/rats are just not as dramatic as the ones seen in younger lab rats/mice. They conclude with what was said in the 1st study…

“The current study leads to the conclusion that flurbiprofen-stimulated periosteal bone growth was due to direct stimulation of osteoblast recruitment and activity independent of longitudinal bone growth. Further, it confirms early findings in young rats that flurbiprofen induced depressed bone resorption without lowering bone formation…”

Implications For Height Increase: 

I realize now in finishing up the post that my judgement was in haste and I jumped the gun on judgement before I did the full analysis of the studies the guys had listed. It is rather clear that flurbiprofen has tremendous potential to increase bone formation in young children in reducing the effects of osteoclasts. However in older adults there would be little height gain. If the periosteal increases are big enough, maybe we might be able to get more cambium cells in the inner layer of the periosteum but that idea was proven to be unlikely in recent posts.

It seems that the other name for flurbiprofen is alfacalcidol and that on aged and adult rats, as stated in the other two studies linked above is that it does have a stimulatory effect on the periosteal growth of long bones. In aged rats, there are even buds of mineralization found in teh cancellous bone and the cortical bone surfaces but nothing that would indicate any type of longitudinal growth of the bones.

It seems that another possible height increase, bone growth enhancing compound goes down again since it does not have any type of chondrogenic properties.