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World’s Tallest Teenage Girl Karabuk Rumeysa Gelgi Might Suffer From Similar Condition As Matthew McGrory

World’s Tallest Teeenage Girl Karabuk Rumeysa Gelgi Might Suffer From Similar Condition As Matthew McGrory

One always manages to find unique stories from various news sources on the internet but this one is slightly interesting. Guinness recently gave the plaque for the World’s Tallest Girl to a Turkish teenager named Karabük Rumeysa Gelgi, who Guinness says is at 7 feet tall. Looking at the pictures of the still very young girl, one notices that she has a abnormally long neck, and slightly proportionally large head. The sources say that she is still 17 and is still going to High School. Height is supposed to be around 7′ 0.6″. The rest of her family is normal height. (source: http://www.guinnessworldrecords.com/news/2014/7/turkeys-rumeysa-gelgi-is-awarded-the-title-of-tallest-teenager-female-in-the-world-58677/)

Rumeysa GelgiThe general diagnosis of her is something known as Weaver’s Syndrome. I’ve only looked into Weaver’s Syndrome maybe once before but this development has almost forced me to look back into the syndrome to see how does it cause excessive increased growth.

Being so young, one should not have many physical conditions, but it seems that she is already having instability and walking problems. In almost every picture we have found of her, she is leaning on a walker. My guess is that she is having problems with her joints and vertebrate areas already.

Tallest-female-3The physicians who examined her have said that she will NOT be growing any more, and that fits very much to what happened with the now deceased Zech Devits as well as Matthew McGrory.

Devit’s conditioned caused him to grow at an insane rate between the ages of 2-13, and then his epiphyseal cartilages completely fused. X-rays done on his vertebrate and joints even at the age of 7-9 showed that Devit’s had compressed discs and was probably starting to suffer lower back pain. By the time Devit’s was even 15, he seemed to have been already confined to the wheelchair.

I don’t have any information on the growth pattern on Matthew McGrory but based on how Gelgi’s body looks, McGrory most likely also had Weaver’s Syndrome if Rumeysa is properly diagnosed.

What is interesting is that the people at TheTallestMan Forums have said that Rumeysa might not be suffering from Weaver’s Syndrome, since she doesn’t really exhibit that big of a macrocephalic features. (Refer here)

Face Features

(Refer to the older posts about Zech Devits and Matt McGrory)

LSJL knee method + Progress update Part I

Note:  This post will provide evidence that LSJL does not merely expand the synovial joints but directly lengthens the bone.

I provided what I consider to be fairly irrefutable proof that I’ve increased finger length.  The issue is that finger length doesn’t come into play in athletics that much.  Larger hands could help in places where increased surface area would come into play.  I also increased wingspan which is more helpful in athletics but I have no documentation and wingspan isn’t measured by doctors.

So I have to return to developing a better methodology for LSJL for the legs which would increase height which is measured by doctors and important in everything in contrast to more niche uses for finger length and wingspan.  Here’s some of the methods I’ve tried.   I got initial results but stopped over time.  One of the reasons could have been that the results were due to dumbell loading since I stopped doing dumbell loading over time but I doubt that the results were due to dumbell loading since 65lbs is so slow.  There might be some sort of adaptive mechanism that reduces effectiveness over time.

The question is:  Why am I gaining length in my finger and arms but not in my legs?

20140623_123745

The answer may be related to angular loading.  When I clamp a bone it begins to bend at an angle. Before I was trying to keep it straight which resulted in the knee popping out in the clamp at the top.  By allowing the knee to tilt the knee becomes trapped within the clamp stopping it from popping out.  My finger and other arm joints always tilt when I’m clamping them and I gained length there so it makes that I can allow for the knee joint to tilt and still gain length in that region.

I’m using the block to increase surface area.  I have to constantly adjust the block and clamp though for keeping it from slipping.  Slipping is far more an issue for leg clamping still so there are further advancements to be made here.

After trying this method for a couple of weeks it was too inconsistent.  Sometimes I would get a really good clamp and generate a lot of pressure other times the clamp would slip off before decent pressure was generated.  So right now I’m using the Irwin Quick Grip and I’ll cover what I’m doing in part II.  But right now I’m mainly focusing on one intense clamp rather than a certain time duration as before but bearing in mind to avoid injury which is possible since I am using so much force when clamping.  Although the time duration method was working with fingers/wing span, I think maximizing intensity is working even better even for fingers/arms.

Finger ComparisonI got a better angle of the finger length comparison.  I am only clamping my right finger and not my left.  You can clearly see that the right finger is definitively longer than the left.  It’s longer than it appears in the picture because I wanted to make sure the right knuckle was higher than the left so people didn’t think I was just sliding the right finger down.

Here’s another angle:

20140709_123054In this one it’s harder to prove that there’s no manipulation to alter finger length but it’s still another perspective.  You can also see the osteophyte on my right finger.  I studied a little bit about osteoarthritis and although osteophytes are a symptom of osteoarthritis they can be caused by other forms of mechanical stimuli too.  So, just because I have osteophytes doesn’t mean I have osteoarthritis.

Now to prove that it’s not just enlarged joints and it’s actually the bone that’s longer.

20140709_123109Comparison of two bones in the finger only and clearly the right finger bone is longer.  So LSJL lengthens bones and does not just merely expand the synovial joint.

Now here’s a thumb comparison.  I’ve only been doing LSJL on my left thumb and not my right.  I figured it would be unlikely for someone to argue that my right hand has always had longer figures if my right index finger was longer then the left but my left thumb was longer than my right.

20140709_123240And it looks like the left thumb is longer but I can’t rule out measurement error since it’s hard to tell exactly when the thumb ends on the hand.

I have before pictures of each appendage but it’s much easier to compare side to side against the contralateral limb.

So here’s some more evidence of LSJL but hopefully also switching up the knee and ankle method will be able to prove LSJL there and that is the big ticket for proof.  So look for Part II soon that explains the current LSJL technique I’m using(I have pretty much finalized the technique but need to take the pictures) and hopefully more LSJL proof.

Michael: I answered your later posts before this one, so I did not realize you accounted for synovial joint expansion.  As for the one question you wanted answered, I will just go back to the fact that the fingers and the arms are not always being pushed upon. With the legs, since we are always walking, the effects of the clamping might be negated by the loading from just walking itself.

As for the osteophyte issue, it is a unique sign that something is not going correctly. Has osteophytes also developed in the finger bone segments which were not clamped?

How Svetlana Zagirovna Sharifullina Developed A Vascularized Fully Functioning Growth Plate

How Svetlana Zagirovna Sharifullina Developed A Vascularized Fully Functioning Growth Plate

Maybe a month ago I had written the post “More Information On Alexander Teplyashin and His Moscow Based Clinics” and said that Teplyashin is not the real mastermind behind the whole stem cell method of bone lengthening. He is a cosmetic plastic surgeon. His Ph. D was on plastic surgery and his specialty is towards minimally invasive approaches to help women have breast implants.

I had said that it is his assistant or colleague who is doing the real research on that. That person is Sharifullina Svetlana Zagirovna. If you type that name into Google, you will find nothing on this person, or very little. That is because you have to use the Russian based search engines and search for her russian name.

Here is what you need to look for in Google or Yandex.

Мультипотентные мезенхимные стромальные клетки жировой ткани и использование их в создании трехмерных трансплантатов хрящевой ткани

It translates into…

Multipotent mesenchymal stromal cells of adipose tissue and their use in the creation of three-dimensional cartilage grafts

Source: http://www.dissercat.com/content/multipotentnye-mezenkhimnye-stromalnye-kletki-zhirovoi-tkani-i-ispolzovanie-ikh-v-sozdanii-t

The Ph. D Candidate’s real name: Шарифуллина, Светлана Загировна. This is what many people don’t realize. When you see Teplyashin’s name on the research papers, you also look at the other people’s names. There is almost always two other researcher’s names that is with him. They are…

  1. Korzhikova SV
  2. Sharifullina SZ

You can see that Sharifullina SZ is this person, who had done through Ph. D thesis on cartilage generation using TGF-beta and stem cells. Like any good leader, they surround themselves with people who are much smarter than themselves, at least in their respective areas of study.

I quote the following from the Ph.D translated by Google Chrome….

2.1.13. A method for obtaining three-dimensional cartilage grafts

Three-dimensional cartilage graft obtained by the method recommended by the manufacturer Biomatrix – BD Biosciences (Germany). The three-dimensional matrix based on polylactic acid (OPLA) or collagen (Collagen) was placed in a 15 ml tube, 150 ul of the cell suspension at a concentration of 5 x 104/ml was applied to the matrix and incubated with orbital shaking at +37 ° C for 2 hours. Then added differential tsirovochnuyu environment and placed in culture for a C02 incubator. Composition differentiating medium: DMEM-HG, 1% Albumin (HSA), 0,1 nM dexamethasone, 0.2 mM ascorbate-2-phosphate, 1 x ITS, 10 ng / ml TGF-J31, 1% antibiotic. Change carried out through the medium every 3 days for 4 weeks.

2.1.14. Preclinical trials – transplantation TTHT based ITCs adipose tissue in the body immunodeficient mice

Preclinical trials conducted in experimental animals, provided by the Russian State University Cancer Research Center. NI RAMS in a joint research agreement. Three-dimensional cartilage tissue grafts prepared in vitro, ectopically sutured back to immunodeficient mice (Balb / C nude) for a period of 8 weeks to assess toxicity and tumorigenicity. After completion of the experiment the animals were euthanized and the grafts removed. In the experiment guided by the requirements of the World Society for the Protection of Animals (WSPA) and the European Convention for the protection of experimental animals.

If you searched further, you’d find her Ph.D is used as a citation on Teplyashin’s personal websites, both StemCelRussia.com and BeautyPlaza.ru
Sharifullina Svetlana ZagirovnaThe Ph.D was defended back in 2007 and it wasn’t until 2011 when another proposal for a project was made entitled “In vitro obtainment of bone marrow multipotent mesenchymal stromal cell three-dimensional bone tissue grafts and their application in bone tissue injury.”

 

This almost agrees exactly with what happened on the Make Me Taller Forums when the news of Teplyashin’s claims first came out maybe 3-4 years ago. That thread on MMT was very much talked about and people did get excited, but over the last few years the MMT crowd seems to have lost interest. It is a shame because based on the time line, I think the Teplyashin research team is actually quite on track in terms of research.

I know from experience that biomedical technology that can finally be taken out of the lab and used in treatments take decades to come about. The rate of the research is actually very, VERY fast. it has been only maybe 3-4 years, which is nothing. I said in the research post that when it comes to biomedical technology development, even hundreds of millions of dollars spent on research might eventually yield nothing in return.

(source: http://www.stemcellrussia.com/en_research_papers)

I also noticed another article Teplyashin’s team wrote up at the bottom of the webpage which caught my eye.

CitationsTeplyashin A.S. HUVEC for Prevascularization of Bone Tissue-Engineered Graft / Kulneva E.I., Korjikova S.V., Teplyashin A.S. // J Biotechnol. – 2010. – V.150. – S1. – P.96-97

It seems that maybe Teplyashin’s team figured out how to solve the vascularization problem that so many surgeons have had in doing epiphyseal growth plate transplantation. The big problem for over a century in getting growth plate transplants to work after implantation has always been that there is a vascularization problem. The scaffold with stem cells embedded inside could not get the blood vessels to wrap and go into the scaffolds and fuse together. It seems that they might have a way to figure that out.

If Zagirovna has been successful in getting the 3-D Cartilage Grafts to be grown, and they got the vascularization problem figure out, then what Teplyashin had been claiming is absolutely true.

How Yakson House Bone Setting Golki Therapy Massage Is Using Wolff’s Law To Change Facial Bone Shapes

How Yakson House Bone Setting Golki Therapy Massage Is Using Wolff’s Law To Change Facial Bone Shapes

Manipulative SurgeryMy recent interests have been moving towards looking into how some cultures have been using joint manipulation to help treat orthopedic conditions. I even went online and ordered two books.

  1. Treatment by manipulation: A practical handbook for the practitioner and student – by A. G. Timbrell Fisher
  2. Manipulative surgery (Modern surgical monographs) – by A. S. Blundell Bankart

So far only the 2nd one came in. I took a picture of the book to show you guys just how old some of these early 20th century medical texts are. The book by Bankart was written back in the 1930s.

What I have found so fascinating about this non-invasive “surgical” way of treating joint mobility and pain problems back in the 1930s is that they seem to derive many of their knowledge from many other older cultures and medical traditions. I am reminded of what I found when I was searching to find out how many Malaysian, Singaporean, and Hong Kong Bone Setters are still left who has a vast knowledge on how to treat minor orthopedic problems just from hand manipulation. If you actually look at the Wikipedia article on the practice of “Bone Setting” you find out that almost all long standing ethnic groups have had some type of bone setter. If I was to take a guess, these bone setters would be maybe much better than the current chiropractors and people who do rolfing since the theory that they give on why the techniques of manual manipulation works is based on real anatomical facts.

In fact, if people ever did real research to see how modern Chiropractors explain why their techniques worked, they’d probably be very surprised to learn that the theory sounds very pseudo-scientific.

So I started to really look into how the various nations and cultures preform bone setting. That was how I came across this bone remodeling company based on Traditional Korean Medical techniques. You can read more on it from “Bone-setting: The new face of Korea“. The website is at Yaksom House. This 25 year old company seems to have at least 2 dozen offices around South Korea, and some in the Philippines, China, and now in NYC.

The explanation on how the facial bones can be remodeled they explain is due to Wolff’s Law, which we have talked about extensively on the website. The idea is that actual physical, mechanical stimuli to living bone would cause the local area of stimuli which is supposed to cause blood to increase in that area, which would as a result also lead to increased calcium absorption (or deposition). The increase in calcium absorption would make the bone thicker in that region.

I had theorized after reading Dr Becker’s Book on Bioelectricity that the real reason why Wolff’s law would ever work is that the physical stimuli causes electrons in other areas of the bone to be popped out of the atomic lattice and travel to the area of stimuli, and build up/accumulate. The result is that calcium ions, including calcium phosphate and calcium oxalate which are cationic (positive charge) start to go towards the now negatively charged location which is where the excess of electrons would be.

So does very strong, almost painful massages on one’s face really lead to thicker bone surfaces? In some ways it does.

However, the issue is that in Korean (and maybe most East Asian) culture, the desire for females is to have smaller faces to look more feminine. The main reason people go in for this Golki Therapy Massage is to make their faces smaller. It seems the primary foreign clients for the Korean based company is from Japanese women looking to have smaller faces. These asian women want smaller faces to look more attractive.

Facial BonesThe truth is that I am not sure just how it is possible to make the faces of human beings smaller. Just like trying to pull bones longer when there is no cartilage between the bones, I am not sure how any human would be able to exert enough force to make fully ossified facial bones to become elastic and bend in the direction of applied force. I agree that if you look at enough skull bone arrangements you would see that the skull if not one large irregular bone that comes out fully formed, but in multiple parts which sort of fit together like a jig-saw puzzle. However, the adult human face has the bones almost completely fused together.  (Picture source)

The human skull bones are over 1 cm thick, and the bones that make up the frontal side (ie zygomatic bone, maxilla, mandible) are also extremely thick, around 5-8 mm. This is the reason why you find that when guys are fighting and punch each other in the face, the only thing that is broken is the nose, because it is made of cartilage. Cartilage you can punch and break. Bones, not so much, (not without a bat, wrench, or something with much more hardness and force/per square inch, than most human fists). There is the temporozygomatic suture, which is the only place where you have any bone break but that is just one 1 mm thin line where the zygomatic bone meets the infraorbital foramen,, and there is the temporomandibular joint (TMJ), which you can kind of manipulate but those are really the only two places any person can move even slightly. There should not be any joints on the face which would be able to be elastic enough to make the base layer of bones smaller.

The effect of applying Wolff’s Law is in fact going to make the skull of the person getting the massager at least a few layers thicker aka slightly bigger, not smaller. However, what I suspect is happening is that the extremely strong massager is in fact kneading the skin and redistributing the collagen in the skin (Collagen Type I) around. The effect of very strong massages is that the collagen can be pushed thinner, and that is what is really happening. The facial bones are not getting thinner, but thicker. It is the skin layer which is getting thinner, since collagen can be manually moved around.

There will be indeed increased circulation, but there is already too many pseudo-scientific medical devices I’ve seen in the past year which claim some type of benefit from increased circulation. In fact, any time you break tissue and there is a rupture of capillaries, there an increase in circulating. Increased blood flow does not always means a good thing, although all cells in our body does require blood to flow pass them to get the oxygen and nutrients to diffuse to the cells for continued life.

In this case though, the massages are most likely relaxing to the person getting it, and does make the skin slightly better. The fact may be be shrinking aka remodeled but the person who comes out of these sessions probably do feel and look better.

The Efficacy Of Dr. Peter Wehling’s Regenokine Injection Therapy For Pain Treatment

The Efficacy Of Dr. Peter Wehling’s Regenokine Injection Therapy For Pain Treatment

I have recently started to put more emphasize on looking into the current medical technologies being implemented to treat people who have injuries and pain since I believe that many of the techniques that Non-American scientists are doing right now can be eventually be translated into regenerating epiphyseal hyaline cartilage tissue.

The recent podcasts on the Joe Rogan Podcast with the Biohacker Dave Asprey about the incredible types of medical breakthroughs going on in Europe with stem cell applications for knee treatment and back treatment led to the talk of this German Doctor Peter Wehling and his incredible technique which has been called the Regenokine Injection Therapy. (It is also known as Orthokine.)

If you are a regular reader of the website, you might remember me talking about regenokine/orthokine before when Kobe Bryant when questioned by Terrell Owens mentioned going to Dusseldorf to get his knees treated. I believe that there is a Dr. Chris Renna based in the US who has also studied the Regenokine Therapy but Kobe went to Germany to get it done. Dr. Chris Renna seems to be one of the few physicians who can administer the therapy, and he has two offices in Dallas and Santa Monica. (source)

That trip was for knee treatment.

As Joe Rogan explained in a a superficial way, the therapy involves the individual who gets about half a cup of blood extracted out of them, the blood then put into an oven/autoclave to heat the blood organic constituents, then put into some type of centrifuge, spun to get get the right density material (the yellowish material), and injecting the yellowish liquid back into the area of the body.

The basic idea on why this technique works this: the reason many lower body joint areas, most especially the knees, of humans who exercise vigorously start to go into pain, or become swollen is because of inflammation. Inflammation is the body’s immune system’s natural response when tissue is being irritated. It is inflammation which causes the articular cartilage or synovial joints in the knees to increase in thickness causing un-neccessary pain. The yellowish fluid injected back into the body would prevent that area of the body (aka knee) to not into into the stage of inflammation.

I am going to take a shot in the dark on this issue but based on my and Tyler’s research, the inflammations is most often due to Interleukin-1 and MMP-13 expression which gets activated. The injections is probably able to block the expressions of those cytokine from being activated.

So far, the technique worked very well for Kobe and he recommended it to Alex Rodriguez as well.

If we compare the Regenokine Injection Therapy to say Dr. Steven Sampson’s PRP (Platelet-RIch Plasma) Therapy, then we find that Sampson’s PRP technique does not include the heating of the blood part. They still take some blood out of the patient, but only just centrifuges the blood. Again, the centrifuge will push components of different densities into different layers in the centrifuge glass tube. You just suck up the layer with a much high concentration of Platelets and then reinjected back into the joints. The PRP Therapy seems to work although there have been tests suggesting that it is just a placebo effect when two groups were tested with the control group getting just a saline solution.

Note: For more information, refer below

  1. Regenokine Therapy: Strict FDA Regulation Has The Rich And Famous Traveling Abroad For Treatment” by Alexander Bylinkin from Seton Hall University
  2. PRP vs. Kobe’s Regenokine: Which is better for knee arthritis?

Injecting Stem Cells Into The Discs Relieves Back Pain But Does Not Increase Disc Height

Injecting Stem Cells Into The Discs Relieves Back Pain But Does Not Increase Disc Height

A recent message that I got was from a regular reader who stated that besides wanting to be tall, they were also interested in the content of the website because their were suffering from back pain from compressed discs. I had said that we have already found multiple ideas, techniques, and patents which have been shown to work in decompressing the discs.

Let me show the readers what we are talking about. First, if you are looking for ideas on how to find the cutting edge of technology on how to treat compressed IVDs, just google terms like “spinal disc decompression” into Google Patents and you would find dozens of viable ideas. The problem is that these ideas, because they are patented means that other people can’t actually go ahead and build those devices in the patent. Licensing the rights to build the devices proposed in patents require paying licensing fees in the 5 digits.

However, lets’ see what the company Regenexx have been saying about using stem cells to increase disc height. (Source available here). They’ve been trying to use this idea of injecting stem cells into the nucleus pulposus area of the discs to increase the disc width since the 2006-2007 time frame. They’ve already put millions into the researcher. So has this company called Mesoblasts, which might have even put as much as hundreds of millions.

The original study which was even cited in the Business Standard website entitled “New stem cell transplant holds promise for treatment of degenerative disc disease” said that at least in animal testing groups, there was a statistically significant increase in disc height for around 25% of all animals that were tested. (You can look up the research by typing in the term “Wenchun Qu, M.D., Ph.D., of the Mayo Clinic in Rochester, Minnesota” into Google and looking up his research.)

So injecting stem cells into test animals lead them to have longer torsos/bodies. However, that result was not able to be translated into human beings.

The injections of stem cells into the backs of adult humans did NOT increase the disc height.

I quote what Regenexx states below…

 We tried to replicate these animal studies as far back as 2006-7 and it failed miserably. Not a single patient saw a significant increase in disc height.”

Here is what the author states are the two primary reasons…

Reason 1: We humans are bipedal and the lab animals tested like mice or rabbits walk on all fours. ie there is less weight per area the discs are subjected to.

Reason 2: While the decrease in disc height in humans is most often due to chronic, slow biochemical process, which takes years, what happens to the animals in the lab, which have their nucleus pulposus instantly removed and have stem cells implanted just a dramatically.

So here is the good news for people suffering from back pain or decompressed discs which are chronic in nature.

Stem cells injections will decrease back pain. – It will remove disc bulges 

The good thing to understand is that at the end of the message, the writer at Regenexx states that we will absolutely eventually get stem cells to work in increasing disc height, just now right now. I guess we need to wait another 20 years before that type of thing finally starts to happen.