The structure of the Long Bone and the relevance to LSJL

I want to go over an article that provides analysis on the structure of the long bones and what it mean for the effectiveness of the LSJL method.

Unfortunately, the paper provides only information about the diaphysis of the long bone rather than the epiphysis which is where we try to induce growth plates with LSJL but it should still provide some insight.

Structure of long bones in mammals.

“Bone is a two-compartment system with capillaries and some kinds of connective tissue in one compartment separated from fibers of bone collagen, often forming lamellae, in the other.{cartilage is a form of connective tissue, it is these compartments that would be good candidates for forming new growth plates}. Laminar bone consists of stacks of lamellae separated by vascular spaces containing capillary network sheets. It is deposited at the periosteal and endosteal surfaces. Osteonic bone consists of cylinders of lamellae with central vascular spaces. The primary structure of the shafts of mammalian long bones is laminar and laminae often remain as the main component. Secondary osteons are a replacement within laminae. As laminar bones mature, some of the irregular longitudinal capillary spaces in the network sheets enlarge and become less crooked to form secondary osteons{since the connective tissue compartments are within the laminae perhaps degrading the bone from osteons to more laminar bone would help create a better pro-growth plate micro-environment}. Parts of the random networks become ordered longitudinal ones, resulting in collapse of those network spaces not converted to osteons. The residual capillaries become bloodless, making the surviving network spaces difficult to resolve.  For example, laminar bone occurs with osteonic bone in the human femur, although it is rarely figured. Nearly mature bones switch the kind of primary bone deposited at the peripheral (periosteal) surface from laminar to primary osteonic.”

“In the young growing animals examined (beef, sheep, pigs), the shaft is completely made from circumferentially oriented laminae without osteons. In older or even mature animals much of the shaft is still laminar (human, buffalo, deer, horse, oxen, as well as beef, sheep, and pigs).”<-So the presence of osteons in more mature bone could be responsible for the anti-growth plate microenvironment in mature individuals.

Laminar bone is more sheet like whereas osteon bone is more cylindrical.  Thus orientation could affect mesenchymal condensation which is the crucial first step for growth plate formation.

Images of young animal laminal bone:

laminar bone

“Mainly laminar bone, with its characteristic vasculature, survives into the adult in a layer below the periosteum. Within this is a layer of mainly osteonic bone. Bone on the endosteal surface is cancellous. The core consists of marrow.”<-maybe this interruption by osteonic bone interferes with growth plate formation.

“The vascular compartment is at first much wider than the compartment destined to contain bone. It declines in width as the lamellae are deposited in the bone layer, eventually shrinking to contain little more than the capillary network”

Figure I shows more osteonic bone:

osteonic bone

Osteons within laminae bone(mature bone):

osteons within laminae

So these osteons within laminae in adult bone could also potentially disrupt growth plate formation.

The paper mentions that one of the reasons that bones are white rather than pink is that bones do not have that many blood vessels.  This could mean a lack of supply within bone for new growth plate formation.

“The idea that not all vascular compartments contain blood-filled capillaries agrees with the observations that osteons lose their connections with the capillary sheets from which they have been derived”<-restoring this connection might be a key to grow taller.

This study did not address more epiphyseal bone but it does present two problems to neo-growth plate formation and how LSJL might solve them.

1. Osteons might impede new growth plate formation.  LSJL degrades bone via fluid flow and shear strain and may disrupt osteonal impedance.

2.  Bone loses the connection with the capillary sheets that form stem cells over time.  LSJL increases fluid flow which could help restore this connection.

A General Response To People Who Ask Me How To Grow Taller And How To Increase In Height

Yesterday I received an email from a person who felt a little down from their lack of size. I get these types of emails everyday now and for most of them I don’t answer because it would take too much out of me in terms of energy and time if I had to respond to every one of these emails.

What I decided to do is to copy that email of the sender below and also copy my general message to this person, who I am guessing is a guy. To make sure that this person’s online privacy is intact, I will refer to this person by their intitials only, J.T.

The first section was his email to me. The 2nd section was my email in response to his email.


Hi Michael,

Thanks for all the valuable information on your website. Its really helpful.

My name is J & I am 29 years old standing 5.7 inches. Like everyone else even I have been trying to grow tall at least an Inch as I know its not possible to grow any further at this age. I had been tall during my teens but got into light weight lifting, dips & squats when I was in my teens. After that my growth stopped or was very negiligible. My younger brother was around 5 to 6 inches shorter than me at that time and is 2 inches taller than me now. My dad is 5.5 & mom is 5.25 inches tall.
I had been very active during my teens with cycling, playing & hanging & really feel bad that I couldnt grow any taller or my growth stopped too early. I did lot of exercies & used Yoko as well but it didnt help. Its really depressing now as I am touching 30 & there is no hope of any growth. I have seen lot websites which offer money back offers on their products like supplements, books & even seen a yearly subscribtion guide who guarantees growth for all ages. I am sure most of these do not offer any results in reality but just need to know if there is any hope or any substance in any of these offers so that I can at least grow an Inch taller.

Thanks for your help.

Regards,
J.T.


J,

I get emails like the one that you sent everyday. Most of the emails I don’t answer. Since your email is more honest, personal, and sad than others , I wanted to sent to you a longer, more extensive, email which I will use for all emails after this one. At the height that you gave, you are below average in height for adult males if you live in the USA. In other countries you might actually be average, or even slightly on the tall side.

The truth is that there are some things that you can do to increase your height. Stretching, rolfing, going to the chiropractor, traction, all done to decompress the disks in the vertebrate. There is also minimal invasive surgical ideas for your feet and head that are available but the increases are around only 1 inch of increase.

The only one that is currently accepted by medical professionals and guaranteed to give you extra height after you have reached natural bone maturity will involve surgery, where your bones will have to be distracted. Everything else can give you at most around 1 inch of extra height.

The technology is just not there yet for an alternative to the limb lengthening surgery, but there is one idea that I realize could work, which could take around 20 years to implement from the initial breakthrough in proof of concept to actual implementation by physicians and surgeons in the medical clinics around the world. It involves a combination of stem cell implantation combined with the tissue engineering technology. The research on the website actually proved that it could definitely work, at least in lab animals. Fully functional growth plates have been grown in the lab.

The Psychological Aspect Of The Issue

The problem with the issue of height is that it is one of the only things that we have almost no control of, no matter how hard we try. Most things in life, we can change and make better if we worked insanely hard for it consistently with commitment. If you are a person who failed high school, you can still become a surgeon if you worked insanely hard and applied yourself for 15 years. So most of the problems we have in life we can correct.

At some deep level, I think you realize that if you really wanted the height, you can get it, through the surgical method. It might take you 10 years of hard work, saving enough money for the operation, planning, and research and then another 1-2 years of painful physical therapy to get the extra 3-4 inches that we all wish for, but 99.99% of people who wish to be taller don’t want to be taller that badly where they are willing to do ANYTHING, and whatever it takes. However, for that 0.01% of people, they want it that badly, that desperately where they will go through with it. So do you want the increase in height that badly? is it a real MUST for you? Or is it a wish, a prayer, a hope and desire, which is not followed by insane action and dedication?

If you think about it, there are many things in the world, and in the universe that we have no control over, like the weather, occurence of cancer, aging itself, the inevitability of death. However, for most of these things, people don’t get too depressed about. Why? I guess it is because it happens to everyone at the same level or rate.

What I can tell you is that for most people, we are not really frustrated that we might be short or that there is almost nothing we can do about it, or that we are of a certain height. What is really going on is that we are comparing ourselves to other people similar to us, like our brother, our friends, our peers and notice that they are bigger than us. As human beings, we don’t actually judge many things through absolute terms, but in terms of relative values. We feel bad that we are 5′ 7″ because it seems that everyone else around us is 5′ 11″ or over 6 feet and we think that because they are taller than us, maybe that also means that they are at some intrinsic level ‘better’ than us.

If there was some other way that you could feel better about your self, then you probably wouldn’t have the problem of feeling insecure or sad about your height. If you are 5′ 7″ but have an IQ of 155 and a mathematics prodigy while the rest of the people around you are over 6 feet tall but have average intelligence, you would subconsciously latch on the fact that you are smarter than the people around you to give you an inner locus of confidence, to make your own ego rationalize why you are ‘better’ than other people. As long as you can link/ associate your own self image to something which you feel proud of and have confidence in, you would feel better and not worry about your size, because that would be a part of your identity which you place no value or importance in. It may surprise you but there are a lot of people in the world shorter than you who are completely happy with their height (even men) because they judge their own self worth through some other standard or value system.

If It would help, I would suggest one of the greatest self help books ever published Psycho-Cybernetics by Dr. Maxwell Maltz. The book focuses on how you can change your self image of yourself to gain more confidence and happiness in your life. It is available through the link on Amazon for less than $7. I am an affiliate of Amazon Associates so I get a small commission if you buy the book through the link above.

Note: This unconscious drive to constantly be comparing ourselves to other people is inherent in almost all culture that stresses the individual and competition, if not being completely universal in human kind.

I am reminded of the quote “I cried because I had no shoes until I met a man who had no feet”. There are definitely a lot of people in this worse off than us. If one is 5′ 7″, one can always find someone else that is 5′ 6″. If we can’t be the type of person we wish to be, it still might be reasonable to find a tall or taller mate to be with to have taller children. I would like to present to you the life of a very inspirational man Sean Stephenson, a guy who suffers from a rare genetic condition known as Osteogenesis Imperfecta, which makes him only 3 feet tall, and confined to a wheelchair. I wrote about him in one of the earliest post for the website at the link below.

http://www.naturalheightgrowth.com/2012/07/31/sean-stephenson-3-foot-giant-in-a-wheelchair/

I also wrote about Nick Vijivic…

http://www.naturalheightgrowth.com/2012/08/02/nick-vujicic-how-to-live-an-inspired-life-without-limbs/

If you are worried at some level that being shorter means that you can’t meet a great partner, gf or bf, then you would be wrong. Both Nick and Sean are married to great women and their physical limitations did not limit them. It is interesting to note that some of the greatest men in History like Jesus and Alexander the Great were both below average in height for people in their time. The point is to show that your below average in stature will not stop you from finding success in either your professional life or personal life, from finding the right person to marry or getting the prestigious job.

In The End…

Me and Tyler are working on the research and hoping to at least make the best website on the internet on this subject. Even if in the end we don’t achieve the real goal, at least we made the internet a better place.

Look, we all go through immense pain in life. You must have heard of the phrase “life is not fair”. I am doing this entire thing because I was coming from a place of immense pain. I chose to focus on doing great things and making things better and taking immense action. I hope you can take something from this email. The least that I can hope for is that you can look at your situation differently and feel a little better of what you do have, and show you that you are not limited by your body.

Take care,

Michael

Quest4Height joins NaturalHeightGrowth, LSJL Update and Plans

I’m going to be going over all the posts on the Quest For Height blog and posting new posts here going over all the important information.

Right now I’m trying to lose body fat to make LSJL related changes more visible.  This will make it much easier to judge any changes in bone length as you can visualize more exactly when the bone begins and ends.  There already is pretty low bodyfat in the hands, knee, and ankle area but it can be decreased.

Right now, I want to go over an LSJL case study.  He reports that his night height is now equal to his morning height so a gain of about 0.8cm.  We cannot however be sure that an increase in bone length is responsible for the height increase as he did not gain in his maximal height.

He reports loading 7 days a week and using a vibrating sports massager on the epiphysis of the long bones of the ankle and knee(he does the massager until he feels pain). He does 100 kicks before doing LSJL. He also uses an inversion table while holding a 20L water bottle for 100 sit up reps and does a 100 back rolls.  So his night height increase could be a result of less loss of intervertebral disc height throughout the day.

Supplements: Sam-e, Chondroitin+Glucosamine, and TMG(trimethylglycine)-no known height increase effects known for this as of now.

Here’s his after ankle pice:

View ankle.jpg in slide show

Here’s the before LSJL ankle pic:

View ankle before.jpg in slide show

Not ideal as it was the only such pic he had available but you can tell that the ankle is much less protruding.  The outer ankle is blocked in the the before pic but the inner ankle is more protruding as well and the inner ankle is what is the limiting factor the lower leg length being the tibia.

He reports that his knees are now thicker than his calves.  His knees look thicker than normal, I can’t say they are thicker than before without any before reference pics.  It looks like his outer knee is higher up than his inner knee but it’s hard to tell.  Adjusting the load so that there’s more pressure on the inner knee may help him gain more height.

leg

The interesting thing about my finger loading is that it’s mainly one side of the epiphysis that’s getting thicker than the other(I will post a finger update soon on the NHG blog).  Perhaps when performing LSJL only one side of the epiphysis is stimulated whichever one receives more hydrostatic pressure and total bone length would be limited by the shorter side.

So an LSJL key could be adjusting the clamping so that both sides of the epiphysis are stimulated which could be hard for the knee as it is obstructed by the fibula.

Increase Long Bone Length And Increase Height By Inhibiting Complete Ossification Of The Epiphysis Through Ischemia (Big Breakthrough)

While I was doing research on how the alignement of a double growth plate would lead to potential unlimited lengthening of the long bones, I took a deeper look at how the ossification centers and realized something which I was surprised I had missed before.

In one of the most important posts written for the website where I had analyzed how the antlers in some deer fall off and regrow in length each and every year, I had noted that to be able to get the type of lengthening you need to have a tip area which has mesenchyme, and that it must be covered by a type of tissue that is either perichondrium, or has the elastic and impermeable nature of perichondrium.

The posts were

  1. The Connection Between Regenerating Deer Antlers and The PTHrP, PTH And IHH pathway for Cartilage Regulation, PTHrP Seems To Be The Answer (Big Breakthrough!)
  2. Increase Height And Grow Taller From Deer Antler Regeneration Principles

deer-antlerSee the diagram on how tissue would have to align for any type of tissue expansion to happen.

You see that the bone has to be at the bottom, while at the edge or tip, it has to have the progenitor cells/mesenchyme ready to differentiate into the chondrogenic lineage which is will what be the tissue that can really expand the structure volumetrically.

Now, Let’s look at the tip or ends of a long bone to see the difference. The long bones are growing longer or longitudinally because the growth plates are pushing the bony secondary ossification center outwards away from the primary ossification layer.

primary secondary ossification centers

 

The ends or tip of the bones, which are known as the epiphysis have a core of ossified cartilage (aka bone tissue) and that grows out until it envelops all of the tissue of the structure at the knobby ends of the long bone except for the articular cartilage.

However the thing that I noticed in this picture which may not be shown in other anatomical diagrams of bone tissue is that there are blood vessel that are going into the epiphysis and the diaphysis. I had forgotten about a very important point which I had researched months ago as well as also forget one of the most basic points of the cartilage-bone tissue relationship.

The first thing I forgot was that there was a study that showed that if you take an awl, and put the awl in a hole that was made from a drilling into the diaphysis of the long bone, and then turn the awl around, basically cutting the blood vessels thus restricting the blood vessels and nutrients from reaching the various regions of the long bone, you notice that the longitudinal growth of the long bone seem to increase slightly.

The 2nd thing that I forgot was that for cartilage to ever turn into bone, it has to go through a process where it’s protective covering, the perichondrium has to start to fail in its strength, the cartilage get invaded by blood vessels that gets inside, and over time, the vascularization leads to the introduction of calcium minerals, leading to then mineralization and calcification, and thus ossification.

Proposed Method For Height Increase

We can get the long bones to ‘grow’ or lengthen by making sure that the ends keep on pushing away from it. As long as the end of a bone structure is filled with material that is not bone, or at least not completely made form bone tissue, just as the case with the tip of the antlers in deer structure. The bone was the tissue at the base but at the tip was only mesenchyme that would turn into cartilage. Somehow the mesenchyme never turned into bones themselves until the mesenchyme was completely used up.

growth plate blood vesselWe see from many anatomical diagrams that there is at least one major blood vessel going through the epiphysis of the long bones to supply it with the proteins and nutrients to continue to make organic living cells like the mesenchymal stem cells that are in the epiphysis. However that blood vessel is also the main cause of the epiphysis/ ends of the bones turning into bones through ossification in the first place. There is one famous study that shows that if you disrupt the blood vessels going into the metaphysis (or the diaphysis) of the long bone, the longitudinal growth of the overall bone is increased. This shows the possibility that if you disrupt the blood vessels that are doing the vascularization of one of the sides of the growth plate, the bone is supposed to get longer.

The proposed idea is to drill a small hole into the epiphysis and disrupt the blood vessels going into the epiphysis, to keep the tissue in the epiphysis in a relatively large percentage of cartilage tissue. My proposal is that as long as the ends of the long bones are not completely infiltrated by blood vessels, they will stay in a state more like a the tip of the antlers of deer, which has the possibility of turning into chondrocytes and this means that the lengthening of the ends of long bones becomes a possibility.

So there are two parts.

1. Drill a hole into the epiphysis and disrupt the vascularization of the ends of the long bones. This would help keep the entire region from turning into bone tissue. 

2. Inject through syringe around 50 ng of BMP-7/OP-1 per gram of tissue into the hole. I have stated recently that out of all the BMPs, the BMP-7 seem to have the most chondrogenic benefits. This would help in turning any mesenchyme/ progenitor cells that did not get destroyed to convert into chondrocytes and possibly then cartilage.

The result is the epiphysis/ends of the long bones becoming softer, more elastic, and more like the tips of deer antlers which can push out and lengthen the ends of the long bones.

The post that really got the core idea started isStudying Changes In The Growth Plate By Restricting The Blood Vessel Supply, Ischaemiawhere I referenced a very old study done by a surgeon named Albert B. Ferguson namedSURGICAL STIMULATION OF BONE GROWTH BY A NEW PROCEDURE – PRELIMINARY REPORT. Ferguson was also the man who showed to me one of the most crucial ideas on how to possibly increase height using a very practical idea which can be easily done at the comfort of one’s home, which I had coined the Chisel and Hammer method, which I would show in the YouTube VideoChisel and Hammer Method Explained“. The basic idea behind the Chisel and Hammer Method is to break apart the periosteum layer so that the growth plate tissue would be less restrictive in their ability to expand.

How Sox 5, 6, and 9 drive chondrogenesis

The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis.

“SOX9 is a transcriptional activator required for chondrogenesis, and SOX5 and SOX6 are closely related DNA-binding proteins that critically enhance its function. We use here genome-wide approaches to gain novel insights into the full spectrum of the target genes and modes of action of this chondrogenic trio. Using the RCS cell line as a faithful model for proliferating/early prehypertrophic growth plate chondrocytes, we uncover that SOX6 and SOX9 bind thousands of genomic sites, frequently and most efficiently near each other. SOX9 recognizes pairs of inverted SOX motifs, whereas SOX6 favors pairs of tandem SOX motifs. The SOX proteins primarily target enhancers. While binding to a small fraction of typical enhancers, they bind multiple sites on almost all super-enhancers (SEs) present in RCS cells. These SEs are predominantly linked to cartilage-specific genes. The SOX proteins effectively work together to activate these SEs and are required for in vivo expression of their associated genes. These genes encode key regulatory factors, including the SOX trio proteins, and all essential cartilage extracellular matrix components. Chst11, Fgfr3, Runx2 and Runx3 are among many other newly identified SOX trio targets. SOX9 and SOX5/SOX6 thus cooperate genome-wide, primarily through SEs, to implement the growth plate chondrocyte differentiation program.”

“Once settled in skeletogenic sites, progenitor cells coalesce into precartilaginous condensations and activate the chondrocyte differentiation program. Early-stage chondrocytes proliferate and build an abundant, cartilage-specific extracellular matrix. They express such genes as Col2a1 (encoding collagen type II) and Acan (proteoglycan aggrecan). Elongation of cartilage anlagen occurs in growth plates, structures in which chondrocytes proceed through terminal maturation steps in a precise spatial and temporal manner. They proliferate and produce cartilage matrix while aligning into longitudinal columns. They then cease proliferation, become prehypertrophic and express novel markers, such as Ihh (Indian hedgehog). As they become hypertrophic, they turn off most early markers and activate unique ones, including Col10a1 (collagen type X). They eventually die or switch to the osteoblast fate to participate in endochondral ossification. Chondrocytes forming permanent cartilage never proceed through these growth plate maturation steps. They keep expressing pancartilaginous early-chondrocyte markers and also express tissue-specific markers. For instance, superficial articular chondrocytes distinctively express Prg4 (lubricin).”

“Expression of the three SOX genes culminates in growth plate proliferating and prehypertrophic chondrocytes, and is abruptly turned off when chondrocytes undergo hypertrophy. SOX9 is required for chondrogenesis.”

“SOX9 is required to turn on and maintain chondrocyte-specific genes and that SOX5/6 strikingly augment SOX9’s transcriptional activity by securing SOX9 binding to DNA”

“The phenotype of RCS[rat chondrosarcoma] cells thus faithfully matches that of growth plate chondrocytes at the proliferating/early prehypertrophic stage. “<-For more on this read the study.

“RCS cells are bona fide growth plate proliferating/prehypertrophic chondrocytes “<-Since chondrosarcoma can occur in older individuals this is a very promising statement for the creation of neo-growth plates.

Bone Replacement Implant To Lengthen Limbs Without Surgery

I was going through the forum Make Me Taller when a certain thread did increase my curiosity JTS Implant for height increase?. The forum members were rather excited about this technology and the science is indeed there backing up what is claimed.

It seems that there is a way for at least young kids to lengthen their legs using a type of device that does not involve surgery. There is actually a YouTube video referenced entitled “What Is The Lengthening Procedure Like?”

On the website Implants For Children there is a section that talks about what exactly is the JTS implant at “What Is JTS?

The Science Behind This Limb Lengthening Method Without Surgery

Due to some type of illness or disorder which will cause the bone tissue in a limb/leg to be useless and can not be saved by surgeons, there is a type of metal implant that is surgically implanted in the place where bone tissue used to be.

This implant is mechanical in nature. There is a small but powerful gearbox in the implant. The gearbox is strong enough to release an output force which is high enough to pull legs apart using a special gear mechanism.

To lengthen the leg, the gear is put in an external drive unit. The drive unit is turned on causing electrical current to run through the electrical coil in the drive unit. This causes a magnetic force to be created rotating at 3000 rpm.

From the webpage…

“This rotation is captured by the magnet within the implant and is passed through the gearbox to extend the device. The implant will grow at 1mm every 4 minutes, thereby slowly stretching the soft tissues”

The benefits of this type of leg lengthening is that is is very precise, it is noninvasive for the stretching, does not require sedation, low chance for infection, is almost pain free, and the patient can go home the exact same day.

Implication For Height Increase Seekers

While the forum members got slightly excited about this prospective new method, they quickly become disenchanted when they found out that this method would involve where there would have to be a metal implant permanently placed in their body as well as having a major portion of their leg bone removed for the metal implant to be go in.

The device is only allowed for kids who have suffered from some type of disorder which caused major parts of the bone tissue in their leg to be damaged beyond repair and the child also has to be young enough where they would most likely still have growth plates meaning that they are supposed to be still growing taller. The implant is almost always done for one leg only so that the implant can increase in length at the same rate as the other leg which is not infected so that when the child is finished growing taller and the growth plates in the limbs fuse, the implant is finally set in its final length and no longer increased any more.

The technology is really incredible, but I would suspect that most people who want to grow taller would have no desire to go through a very invasive surgery in the beginning and have an extendible metal implant permanently placed in their body. It probably makes more sense for people to go through with the limb lengthening surgery with the external fixator or internal rods to increase the length of their legs instead because at least after 2 years at most (usually 1-15 year), a 2nd major surgery is done where the internal rods or the external fixator is finally removed.

This method for potential height increase is viable, but there probably is not that many people who would be willing to go through with it. In Addition, of the few locations around the world which does this type of metal implant and external drive lengthening, none of them currently would allow any healthy person with good legs to go through with this type of surgery for a cosmetic reason for only increasing their height.