Me: This was a patent I found. In the patent however the growth modulator is used to compensate for the disproportionate growth found in defective vertebrate. The growth modulator is generally administered using a delivery device suitable for delivery of therapeutics into bone, such as a suitable needle for delivery of liquid or semi-liquid (e.g. semi-viscous liquid) formulations, or via a catheter device for delivery of solid and semi-solid formulations. It seems that the long metal needle used to be stuck into the vertebrate growth plate is a physiologically acceptable carrier for administration to an epiphyseal growth plate. From the patent…

As typically observed in congenital scoliosis, abnormal vertebrae growth arises from the premature partial fusion of the epiphyseal growth plate. In the region of premature partial fusion, the chondrocytes generally exhibit decreased activity, thereby retarding the growth of the defective vertebrae in the region of the partial fusion. The end effect is concavity in the region of partial fusion

From the patent…“The intervertebral disk 134 can also serve as a temporary reservoir of growth modulator. In this delivery methodology, termed discal delivery and shown in FIG. 12, the growth modulator is deposited within the fibrocartilaginous structure of the disk 134 wherefrom it diffuses into the adjacent vertebrae. To promote diffusion into the appropriate target area, the growth modulator is generally deposited into the disk in the area immediately adjacent to the area of the vertebrae 120 requiring growth modulation.”

Analysis: 

There is two major proof of concept from this patent.

1. The idea that one can just directly inject growth modulators into the epiphyseal plates, whether they are from either the irregular bones of the vertebrate or the long bones in the legs/arms to make the cartilage plates grow faster and further
2. The growth modulator seems to be okay to be used for even partially fused epiphyseal plates, which seems to prove the idea Tyler has been proposed that even partially fused epiphyseal plates can overcome a bone bridge and cause longitudinal growth.

The  positive growth modulator comprises one of…

1. a natural growth hormone, somatotropin
2. an exogenous bone growth stimulant
3. a somatotropin analogues
4. agent comprises fibroblast growth factor (FGF), bone morphogenic proteins (BMPs), stem cells, vascular endothelial growth factor (VEGF), angiogenic growth factors, blood flow control agents and vascularity enhancing factors.

The growth modulator has 3 key components.

1. Stem cells
2. A chondrocyte growth factor
3. A natriuretic peptide

Patent application title: MODULATING BONE GROWTH IN TREATING SCOLIOSIS
Inventors:  Kieran Murphy (Toronto, CA)
IPC8 Class: AA61K3512FI
USPC Class: 424 937
Class name: Drug, bio-affecting and body treating compositions whole live micro-organism, cell, or virus containing animal or plant cell
Publication date: 2010-09-02
Patent application number: 20100221229

From source link HERE…

Abstract:

The present specification provides, amongst other things, a method of treating scoliosis comprising delivering a therapeutically acceptable amount of a growth modulator to an epiphyseal growth plate to correct or compensate for disproportionate growth.

FIELD

[0002] – The present invention pertains to the field of scoliosis, in particular to the treatment of scoliosis using growth modulators.

SUMMARY

[0003] – According to a first aspect, provided is a method of treating scoliosis, comprising delivering a therapeutically acceptable amount of a growth modulator to an epiphyseal growth plate to correct or compensate for disproportionate growth.

[0004] – According to a further aspect, provided is a composition comprising a therapeutically acceptable amount of a growth modulator and a physiologically acceptable carrier for administration to an epiphyseal growth plate. According to another aspect, provided is a method of treating scoliosis, comprising the delivery of a growth modulator to a target region of an epiphyseal growth plate for altering the growth in said target region.

[0005]According to a further aspect, provided is a method of treating scoliosis, comprising delivering a therapeutically acceptable amount of a growth modulator to selected portions of an epiphyseal growth plate to correct or compensate for disproportionate growth.

Claims:

1. A method of treating scoliosis, comprising delivering a therapeutically acceptable amount of a growth modulator to an epiphyseal growth plate to correct or compensate for disproportionate growth.

2. The method of claim 1 wherein said growth modulator is a positive growth modulator to stimulate growth.

3. The method of claim 2 wherein said positive growth modulator is introduced into a vertebrae adjacent to a defective vertebrae in a manner that physiologically compensates for the disproportionate growth of said defective vertebrae.

4. The method of claim 3 wherein said positive growth modulator is introduced into an epiphyseal growth plate of said adjacent vertebrae in a region adjacent to a partially fused epiphyseal growth plate of said defective vertebrae.

5. The method of claim 2 wherein said positive growth modulator comprises one of a natural growth hormone, somatotropin, an exogenous bone growth stimulant, and a somatotropin analogues.

6. The method of claim 2 wherein said positive growth modulator comprises a biosynthetic human growth hormone

7. The method of claim 6 wherein said biosynthetic human growth hormone comprises one of Nutropin (Genentech), Humatrope (Lilly), Genotropin (Pfizer), Norditropin (Novo), and Saizen (Merck Serono).

8. The method of claim 2 wherein a positive growth modulator comprises a suitable inhibitor of endochondral ossification.

9. The method of claim 8 wherein said inhibitor of endochondral ossification comprises chondromodulin-1.

10. The method of claim 2 wherein said positive growth modulator comprises one of stem cells, a chondrocyte growth factor (CGF), and a natriuretic peptide.

11. The method of claim 1 wherein said growth modulator is a negative growth to inhibit growth.

12. The method of claim 3 wherein the negative growth modulator is introduced into an epiphyseal growth plate in order to decrease an extent of wedge formation in a growing defective vertebrae.

13. The method of claim 11 wherein said negative growth modulator comprises an agent that ceases chondrocyte activity or promotes ossification of the cartilagenous tissue.

14. The method of claim 11 wherein said negative growth modulator comprises agents that increase vascularization or promote the ossification of the epiphyseal growth plate tissue.

15. The method of claim 11 wherein said agent comprises fibroblast growth factor (FGF), bone morphogenic proteins (BMPs), stem cells, vascular endothelial growth factor (VEGF), angiogenic growth factors, blood flow control agents and vascularity enhancing factors.

16. The method of claim 11 wherein said negative growth modulator comprises a chemotherapeutic agent therapeutically effective to interfere with an ability of cells to grow.

17. The method of claim 16 wherein said chemotherapeutic agent comprises one of alkylating agents, anthracyclines, cytoskeletal disruptors, epothilones, inhibitors of topoisomerase II, nucleotide analogs and precursor analogs, Peptide antibiotics, retinoids, and vinca alkaloids and derivatives.

18. The method of claim 11 wherein said negative growth modulator comprises one of an antibiotic, an antimitotic, an antimicrobial, an alcohol, a protein, a disinfectant, a hydroxyapatite, and a metal.

19. A composition comprising a therapeutically acceptable amount of a growth modulator and a physiologically acceptable carrier for administration to an epiphyseal growth plate.

20. A method of treating scoliosis, comprising the delivery of a growth modulator to a target region of an epiphyseal growth plate for altering the growth in said target region.

21. A method of treating scoliosis, comprising delivering a therapeutically acceptable amount of a growth modulator to selected portions of an epiphyseal growth plate to correct or compensate for disproportionate growth.

Me: This is going to be the start of a proposed idea on how to increase height using a two step process. From a lot of the research, we have already found many, many ways to make bone fractures heal. That part is easy. In addition, we have also found many ways to induce the creation of chondrocytes from some form of external stimuli, whether chemical, mechanical, electrical, to cause the right type of differentiation in progenitor cells. Let’s assume first that because the inorganic compound in bones, the Hydroxylapatite (Calcium & Phosphorous element combination) which causes the bone to have it’s intrinsic quality of being so tough and hard, with a compressive and tensile strength in the level of stainless steel. Let’s say for argument that if the hypertrophy of chondrocytes in the epiphysis was not enough to cause long bone lengthening through hydrostatic pressure and expansion of the trabecular and cortical bone, we would then need to find another way to cause the hard bone to separate, at least long enough for chondrocytes and cartilage to get between the hard inorganic spaces to push them apart. This is way I have almost always believed that besides the LSJL method which seems promising, there may be no way to cause adult height increase in a non-invasive way. I thought that a bone distraction or fracture was needed. However, after going through the literature recently I have concluded instead that maybe it is possible if we can use some form of process to demineralize the Hydroxylapatite from the bone matrix at a level where the tensile strength of the bone is dramatically decreased. I remember reading from HeightQuest that Tyler suspected that the Ginza Kojima machine operated on this principle where the green light emitted or the chemical bath used was to somehow demineralize the bone and give it a lower young’s modulus value. Then a torsional or twisting load was made to the bone since the torsional loading value of long bones with the cortical bone was not that high. From what Tyler, Sky, and I have seen the machine has been around on the market for many years now with little news or press placed on it. In my opinion, mineralization may be a key step that might be required to be added on for the entire height increase technique to work. There might indeed be a step where limbs are subjected to some form of chemical, electrical stimuli, or other to weaken the bones a little.

Analysis: In the study the researchers used a suitable method for rapid demineralization of mouse teeth in 0.1 M (molar) EDTA (ethylene diamine tetra-acetic acid) at 42˚C . From the study the mice were eventually killed to study the bone mineralization so obviously this type of testing can’t be done on human subjects but the major take away should be that we can try these methods where the subject’s limb is placed in a weak acid mixture, have the heat increased, (maybe not as high as 42 C) and slowly over time have the bones demineralized for possible tensile loading later. It has already been reported that bone demineralization was accelerated by microwave treatment to heat the subjected bone up and increased the rate of dimeralization by 2X, or at least with tested mice skulls. In the study, the researchers showed that there are plenty of stronger acids out there that can do the demineralization work a lot better and faster but that woudl destroy the genes and gene expression of the underlying body tissue, which would include for a live human subject muscle and bone and ligaments. We obviously want to avoid that. It would require more research to find a better acid solution that can extract bone minerals while keeping most other tissues safe and intact.

Overall, this is my first crude attempt at trying to find a way to dimineralize the bones. I would suspect for future testing, it may be a better idea to focus on just a small 4-5 mm thick layer of axial directional bone and try to dimineralize that. area. If that that process is successful, we can either induce chondrocytes to replace those areas where the hydroxylapatite was or increase the activity of osteoclasts to remove the bone material for growth factors and progenitor chondrogenetic cells.

From source link HERE…

A Method for Rapid Demineralization of Teeth and Bones

Andrew Cho, Shigeki Suzuki, Junko Hatakeyama, Naoto Haruyama, and Ashok B. Kulkarni

Abstract: Tooth and bone specimen require extensive demineralization for careful analysis of cell morphology, as well as gene and protein expression levels. The LacZ gene, which encodes the ß-galactosidase enzyme, is often used as a reporter gene to study gene-structure function, tissue-specific expression by a promoter, cell lineage and fate. This reporter gene is particularly useful for analyzing the spatial and temporal gene expression pattern, by expressing the LacZ gene under the control of a promoter of interest. To analyze LacZ activity, and the expression of other genes and their protein products in teeth and bones, it is necessary to carry out a complete demineralization of the specimen before cutting sections. However, strong acids, such as formic acid used for tooth demineralization, destroy the activities of enzymes including those of ß-galactosidase. Therefore, most protocols currently use mild acids such as 0.1 M ethylene diamine tetra-acetic acid (EDTA) for demineralization of tooth and bone specimen, which require a longer period of treatment for complete demineralization. A method by which hard tissue specimens such as teeth and bones can be rapidly, but gently, decalcified is necessary to save time and effort. Here, we report a suitable method for rapid demineralization of mouse teeth in 0.1 M EDTA at 42˚C without any loss of ß-galactosidase activity.

INTRODUCTION

Teeth are the hardest tissues in the body, consisting of enamel, dentin, and cementum, and have a highly mineralized extracellular matrix. Unlike soft tissues, which can be easily sectioned and analyzed, teeth require complete demineralization in order to prepare proper sections for histological
analysis using certain stains and antibodies. In the past, many decalcifiers have been tested for different purposes. For example, the Morse’s solution, a strong acid baseddecalcifier, has been used for the rapid detection of RNA by in-situ hybridization (ISH) [1]. Another acid-based solution,
5% trichloroacetic acid (TCA), has been used for the analysis of DNA strand breaks by terminal deoxy (d)-UTP nickend labeling (Tunnel) [2]. EDTA containing solution is a mild demineralization agent which has been mostly used for immunolocalization studies because of its antigen-preserving
properties. Treatment of bones with 0.1 M EDTA following initial fixation in glutaraldehyde has been reported as adequate for immunocytochemical localization of certain bone matrix proteins [3]. Furthermore, the treatment of dental tissues with 4.3% EDTA resulted in satisfactory preservation of the fine structures of the cells and matrices [4], however it requires a relatively long incubation time in order to achieve complete demineralization [5,6]. For example, to demineralize human deciduous teeth for analysis, it requires 4 weeks of demineralization using 10% EDTA [7]. To demineralize a 1-month-old mouse skull with similar EDTA solution it takes about 3-4 weeks of treatment to prepare the specimen for analyzing expression levels of the LacZ and growth fac

*Address correspondence to this author at the Chief, FGS, CDBRB, NIDCR, NIH, Tel: 301-435-2887; Fax: 301-435-288; E-mail: ak40m@nih.gov tor genes [8,9].

To achieve fast demineralization, a microwave-induced demineralization method has been examined [10,11]. While this method has achieved faster demineralization time compared to the traditional method, preserved the fine morphological structures of the bone tissue, and retained RNA, its effect on LacZ gene expression has not been addressed. Moreover it has been speculated that the advantages associated with using the method are due to the higher temperature attained during microwaving the specimen purely due to thermal effect [12]. The LacZ gene is widely used to investigate promoter activity [13-15], however there is not detailed protocol for optimal analysis of ß-galactosidase activity in decalcified mouse teeth and bones. Moreover, the effects of acid-based decalcifiers and different fixatives used for preparation of mouse teeth specimen to analyze ß-galactosidase activity have not been well established. In this report, we demonstrate the effects of several fixatives and decalcifiers on mouse teeth specimen for LacZ activity, whose expression is driven by a tooth specific DSPP (Dentin Sialophophoprotein) promoter. Most importantly, we have explored the effects of elevated temperatures on mouse teeth specimen to optimize a rapid but gentle demineralization method suitable for analysis of LacZ activity. This will prove to be a suitable method for rapid demineralization of mouse skulls for analysis using histochemical staining and in-situ hybridization.

DISCUSSION 

We set out to optimize the demineralization method in order to make it shorter and safer for histological analysis of mouse teeth. In the process of this optimization, we addressed some of the key issues related to the effects of the decalcifiers and fixatives used for preparing the mouse skull specimen. Our study indicates that the demineralization of mouse skulls at 42°C using 0.1M EDTA can significantly shorten the time required for complete demineralization, while also retaining sufficient ß-galactosidase activity. DSPP, a key dentin extracellular matrix protein secreted by odontoblasts, plays a crucial role in the mineralization of predentin to form mature dentin [18-21]. We previously reported the isolation and characterization of the murine Dspp gene [22] and the validation of its promoter sequence [16]. The Dspp-LacZ transgenic mice used in the present study to display spatial and temporal expression patterns similar to endogenous DSPP expression profiles [16]. In these mice, the LacZ gene, which is placed under the DSPP promoter sequence, is expressed as early as embryonic day 17.5 (E17.5) in preameloblasts and odontoblasts, and at E18.5 in molars. Its expression in preameloblasts is transient, whereas it stays robust in odontoblasts throughout tooth development. Because of this expression profile, the tooth specimens from these mice are ideal for testing the effects of decalcifiers, fixatives and incubation conditions on the stability of ß-galactosidase activity. However, because the LacZ gene, which encodes ß-galactosidase, has been widely used as a reporter gene to analyze the expression of a gene of interest, the demineralization protocol that we have optimized in the current study can be applied to other transgenic mouse models expressing ß-galactosidase in teeth and bones. We first verified the effects of various fixatives and the fixation time on the stability of the ß-galactosidase enzyme in the tooth sections. We tested 0.25% glutaraldehyde, 4% PFA, zinc formalin and formalin for their effects, and found that all of them work well as fixatives to analyze ß-galactosidase activity in the tooth sections (Fig. 1). As for the fixation time, we found that post-incubation of the skulls with 4% PFA for up to an hour did not have any adverse effects on ß-galactosidase activity. However, extending the incubation time to 2 hours adversely affected the enzyme activity (Fig. 2). As previously reported [17], LacZ enzymatic activity in kidney tissue was also retained during a 1- hour incubation time with 4% PFA, but not during a longer period of time.

Next, we tested the acid-based demineralization reagents, Formical-4 and Immunocal, in order to analyze their effects on ß-galactosidase activity. As you can see in Fig. (3), it is clear that 0.1% EDTA, but not the acid-based demineralization reagents, maintained ß-galactosidase enzyme activity after complete demineralization (Fig. 3). Chelating agents such as EDTA can bind to calcium and other ions and remove them from mineralized tissue. This reaction occurs gently, and enzymatic activity can therefore be retained during demineralization. In contrast, long-term exposure to acidic conditions could potentially destroy enzymatic activity such as ß-galactosidase. Another possibility is that, because Formical-4 and Immunocal contain fixatives, ß-galactosidase may be over-fixed and thus result in a lack of enzymatic activity. As shown in Fig. (4), we then explored the potential for shortening the demineralization process by increasing the temperature during demineralization, since it has already been reported that bone demineralization was accelerated by microwave treatment [10,11]. Our data indicated that incubation of mouse skulls with 0.1M EDTA at 42°C results in demineralization that is 2-fold faster than incubation at room temperature. Our data also revealed that, although an incubation temperature of 50˚C can achieve demineralization the shortest incubation time, it adversely affects the enzyme activity (Fig. 5). These data suggest that incubation at 42°C is most useful for analysis of enzymatic activity in decalcified teeth. Moreover, as shown in Fig. (6), 6 days of incubation with 0.1M EDTA at 42°C was sufficient for complete demineralization of 1-year-old mouse teeth. These observations suggest that any specimens can be demineralized by incubation with 0.1M EDTA at 42°C for 6 days.

To assess the effects of elevated temperatures on the stability of nucleic acids, we extracted total RNA from the tooth sections of the skulls subjected to different temperatures for the demineralization process, and performed RTPCR analysis. The amplification of Gapdh mRNA transcripts at 37°C, 42°C or 50°C showed similar levels, indicating that a higher temperature had no affect on the stability of nucleic acids (Fig. 7).

In summary, we have optimized the conditions for rapid demineralization of mouse skulls, which significantly shortens the time required for complete demineralization but does not affect the enzyme activity or nucleic acids in the tooth sections. We recommend 0.1M EDTA as a safe decalcifier, to be used at 42°C for successful demineralization of mouse skulls. These conditions could be widely applied for the enzymatic and immunohistochemical analysis of other proteins in hard tissues. Moreover, rapid demineralization using this method will promote quicker analysis of genes and proteins implicated in tooth and bone diseases.

ACKNOWLEDGEMENTS

We would like to thank Dr. Taduru Sreenath for his helpful suggestions during the course of this project. We also would like to thank Drs. Marian Young and Larry Fisher for critical reading of the manuscript, and Shelagh Powers for expert editorial corrections. This work was supported by funds from the Division of Intramural Research of the National Institute of Dental and Craniofacial Research.

{Update: It seems that from the main website AyurvedicUrea.com, the main ingredient found in ayurvedic urea is “Dhatrumurgasiniy”. It seems this thing can only be found in Nepal. I will be doing some more research on what this plant/ compound really is.]

What I wanted to do with this post is try to prove conclusively that this new idea for height increase is either something worth looking into or just the newest craze in height increase to com along. When I typed in the words “Ayurvedic Urea Height Increase” into Google, I was surprised at what else I managed to find.

There is a Topix.com Discussion HERE…

From the first looks of it, it would appear that at least a dozen people have all said that it is a real product which worked for them. This seems great until you realize that all the people who said that the product is legitimate have their location traced back to one location, Lalitpur, Nepal. Even what we would say is american names like Bob are coming from the same place. There seems to be another person from the UK also saying it is legitimate so we have two people who are saying it works. Most of the other posters are not sure or claim it is a scam.

From AyurvedicUrea.com…

This website is the official website for the idea to increase height using ayurvedic urea. It seems that this website is based off of San Francisco from the Facebook page profile. They say on their page for scams that you should not buy “fake” ayurvedic urea from any providers from Africa or any one else EXCEPT them. So they seem to want you to only use them as a service. Hm….That makes me suspicious. When an organization is trying this hard to push out any possible competitors by claiming everyone else is a liar and scam artist, that make you wonder if they are a scam too. Something else to note is that the website seems to be based off of the Blogger Blogging Platform. That makes it seem like it is not very professional. However, I would have to concede that this website was built on a blogging platform too, WordPress. From this link HERE these guys say that they are the only people who sell the real Ayurvedic Urea. Are these sellers saying that they are the only people who can make this stuff? The website lists two other websites being fake sites selling fake ayurvedic urea however when I copy and pasted the URL domain names, I got only a standard WordPress 2011 theme with maybe 2 pages of weak content. Sites are www.buyayurvedicurea.com and www.ayurvedicurea.net. If you want to see what is on the websites, go ahead. There is almost nothing on these sites that the other site says makes them a scam. It’s Nothing. From the website there seems to be one “legitimate” sellers of the stuff. NAME: MELINA JATAMARI    CONTACT EMAIL: melinajatamari@gmail.com. Apparently she is the “only seller we have verified and authorized“. What the website does seem to do is hold the money in escrow so that the money you give will only reach them after you have tested the compound and seen its effects. The urea doesn’t seem to work on dwarves. There is research being conducted in Singapore starting around 11//23/2012 and will end in 7/23/2013. The next group of people being tested will be in Thailand. If you want to contact these people email them at support@ayurvedicurea.com. Or get in touch with some women named Sharon Stone (the same as the actress??) Here is the pricing from the website…

From a WordPress blog based website MeetMeDaily.com…

This website seems to be some form of funnel or sales page to get the person to go to the Ayurvedic Urea website. There is absolutely no scientific information on why this product would even work. There is even a Facebook page for Ayurvedic Urea located HERE. From the first look, there is over 6000 likes, and the profile website was created in 2009. The biggest discussion has around 54 comments with most of the profiles saying the product worked on them. However after I clicked on the profiles It showed that the profiles had no pictures, information, or friends. This seems to suggest that someone purposely created a few dozen fake Facebook Profiles to write up fake positive testimonials for this Ayurvedic Urea. There were real profiles who commented to the Facebook page asking how they can buy this extremely expensive product but it seems that no one has answered them back yet.

From AGRHood.com…

One of the podcast I have been listening to for the last 2 years has been Pickup Podcast which I found years ago when I was going through the phase where I was absorbing Personal Development and Self Help material like a sponge. The podcast has been traditionally focused on teaching men how to better their social skills and mindsets to improve their dating life and romantic relationships. In recent times it has moved more in the direction of how to build a stronger core and self image so it has also encompassed “self help”. About 3 years ago, I needed that skills and knowledge base because I realized my own social skills were deficient.

In the most recent “Podcast Episode” where the guys interview the infamous Tim Ferris, who wrote the insanely popular lifestyle design book “The 4 Hour Work Week”, they were discussing Tim’s latest book where he talks about how to find the simplest way to mastery the science (or art) of cooking, using only a few basic elements (ie. Knife, Spices, Cookware, etc.) and also about other ways to hack life to optimize effectiveness, productivity, and time management, something I am a junkie on. If there is one thing I am addicted to still, it is listening to interviews and podcasts where really successful people come on to discuss their strategies and methods on optimizing their life.

If you follow this episode, around the 1:04-1:06 (that is hours btw) mark Tim mentions that he has a friend who has went to China to perform gene therapy testing (or what Dave Asprey would call Bio-Hacking) on himself to see what would be the effects. Tim claims that his friend has managed to increase his weight which was already at 240 lb by another 30 lbs of muscle in 28 days! This seems to be from using gene vectors which I have only begun to get into.

Here are the 3 main genes that the friend has been experimenting on and manipulating.

1. Actin III – For fast twitching muscle fibers
2. Interleukin
3. Myostatin

So far I have already proposed at least 2 possible ways to increase height using gene therapy from changing the DNA of chondrocytes and progenitor mesenchymal stem cells. However what Ferriss’s friend is doing is something I didn’t think was even possible from using gene therapy (or at least legal).

From the Wikipedia article on Gene Therapy we realize that there are actually two types of gene therapy, 1. Somatic Gene Therapy and 2. Germ Line Gene Therapy. Somatic gene therapy is where the effects and modifications happen only on the person which was subjected to the treatment while germ line gene therapy is where the effects also has an effect and modify’s the subject’s offspring too. We are going to only focus on the first type right now and see if we can change our own bodies and not worry about what our kids and descendants will be like.

Getting back to the subject, (as the story goes) this friend went to China and somehow got his hands on some vectors from some supplier in a non-legal way and has managed to change his body at such a dramatic way in a very short time. As far as I know, there is no muscle mass increasing drugs in the market right now that can have this dramatic of an effect, even the most intense ones. Body builders who I have researched because of the link between steroid usage and potential height increase have consistently talked about the effects of some of the craziest stuff. This is at another level.

For me, this type of claim by Tim Ferriss seems to show to me that there are already people who have been successful in using illegal supplies and tried using gene therapy on themselves and gotten results. Since this happened in China (and we know that in China, anything can happen… like in Vegas) we sort of have to take this story with at least some bit of reservation. This story shows that if I (and Tyler and other genetics knowledgeable height increase seeker enthusiasts around the world) can figure out a more complete map on which genes affect the human height development (besides just HMGA2 and LIN28B), we might be able to manipulate our height by causing specific cell differentiation (and maybe even transdifferentiation) from gene vectors in less than 10 years of dedicated research.

This will be another one of those posts which will eventually turn into a section/webpage of the website which will be occasionally edited and added upon. I was not aware of just how big and many books of this type there are. When I was first doing my research, I had no idea that there was this many books all devoted to this topic. The Primary source where I found this list of books was from the “Grow Taller Step” website store section (HERE).

If you want to try out your luck and buy one of the books from the links, then that is your choice. I am not promoting these books on Amazon, only to say that they do exist. The good news for you the website visitor is that a nice number of the books below are already uploaded to the “Downloads” section of this website for you to take for free.

[Note: These books are NOT in alphabetical order, yet]

1. How to Get Taller – Grow Taller By 4 Inches In 8 Weeks, Even After Puberty! – David Taylor – (Amazon Link)
2. How to Get Taller – The Complete Exercise Guide (Grow Taller) – David Taylor – (Amazon Link)
3. How To Grow Taller: Guaranteed Increase Your Height Within 8 Weeks – Peter Douglas (Amazon Link)
4. Growing Taller Secrets: Journey Into The World Of Human Growth And Development, or How To Grow Taller Naturally And Safely. Second Edition – Robert Grand (No Amazon Link)
5. How to Naturally Increase your Height (Grow Taller Guide) – Russian Sports Authority (Amazon Link)
6. How to Grow Taller — The Amazing Secrets to Quickly and Easily Grow Taller! — Get the Respect of Being Stronger, Confident, Taller and More Attractive Today! – Mike Summers (Amazon Link)
7. Grow Taller book – Hayden Carter (Amazon Link)
8. How Can I Grow Taller: Learn How To Increase Height And How To Grow Taller Naturally And Artificially. Height Increase Tips, How To Get Taller With Yoko And More. So Is There A Way To Get Taller? Yes! – Jared D. Carlson (Amazon Link)
9. Increasing Height Through Exercise – Steven C. Cummings (Amazon Link)
10. Increase Your Height – Krishna Gopal Vikal (No Amazon Link)
11. Grow Taller – Statton, Burk, Cunningham Serrano
12. How to Grow Taller “Master Secrets to Growing at Least 4 Inches in 2 Months! – Monica Heart (Amazon Link)
13. This Tall Grow Taller and Taller – The Answer to the Fear of Height [In Japanese Language] – Aiyoshi Kawahata (Amazon Link)
14. How To Grow Taller: A Comprehensive Guide And Revolutionary Exercise Program To Make You Grow – Kanwaljit Singh Kalsi (Amazon Link)
15. Grow Taller Proven Insider Secret Tips and Techniques That Will Help You Grow (Body Image Solutions) – Dr. Jesus Serrano (Amazon Link)
16. The Most Effective Way to Grow Taller (Chinese Edition) – Yang Shu Wen (No Amazon Link)
17. Small Children, Children Grow Taller Quiz – SHI DING PING BIAN ZHU (Amazon Link)
18. Children Naturally Grow Taller (Chinese Edition) – PU XIU SHENG CAO FANG (Amazon Link)
19. How Quickly Children Grow Taller 10 cm (Chinese Edition) – GONG SUI (Amazon Link)
20. You Will Grow Taller at 23 (Chinese Edition) – Jin Yang Xiu (Amazon Link)
21. Natural Human Growing Taller Method (Modul) – Jorge Garcia (Amazon Link)
22. Gaining Height Through Exercise : 100 Straightening and Stretching Exercises to Make You Grow – Pierre Berthelet (Amazon Link)
23. How to Grow Taller Naturally with the Power of Your Mind – Joan M Rivera (No Amazon Link)
24. Grow Taller Now – Unknown (No Amazon link, source link)

Me: There is two patents I found that has the proposed ideas on how we can possibly inject dna mutated chondrocytes into the epiphysis of the femur and tibia to stimulate mesenchymal stem cells to differentiate into chondrocytes correctly.

Analysis:

For Patent 1 – Only a picture of the idea below was used. The idea as always to combine a type of gel system with growth factors in it and have extracted and regrown chondrocytes implanted in it. Then the entire piece is then implanted into a bone defect or fracture or cartilage to heal it.

For Patent 2 – we have a mixture to heal articular cartilage defects comprising of these components through implantation. There are two main pieces. In essence, it is a proliferating chondrocyte cell structure having phenotypic capability embedded in a vehicle or gel.

The first peice is the extracted and cultured chondrocytes of a certain packing density. This is bone marrow derived chondrocytes or osteoblasts of autologous or homologous origin, or homologous committed chondrocytes, or autologous or homologous muscle fibroblast derived chondrocytes or any other progenital cells from mesenchymal origin

The second part is a a biodegradable, biocompatible, biological resorbable immobilization vehicle (BRIV) adhesive glue. This is made of the following compounds

• fibrinogen (100-150 mg/ml)
• thrombin (60-90 units/ml)
• CaCl₂ (an excess of 60 mM CaCl₂.)
• protease inhibitor (selected from the group consisting of polysaccharide inhibitors, plasma protease inhibitors, and synthetic and natural non-plasma protease inhibitors)
• about 10-30% serum (selected from fetal calf serum or umbilical cord serum from the second trimester or horse serum or any combination of such serums. may optionally contain growth factors such as IGF_I, IGF_II, TGFB, PDGF, or any other growth factors that will be found to facilitate the proliferation of the cells)

The chondrocyte population is embedded in the biological glue at a concentration of between from 100,000 to 500,000 cells per milliliter of glue.

For Patent 3 – Patent #3 was written by the same guy who wrote up patent #2 and he wrote it because it turns out patent #2 had a few limitations that was later found out from experiments. It was believed that for the greatest ability in chondrocyte proliferation the best type was embryonic. However this meant the right type of cells was hard to get and there was also the problem with immune system reactions. It would turn out that the concentration limits for the chondrocyte density in gel, the thrombin, and the fibrinogen were not good in actual experimental testing. The compositions and procedures were changed. I have decided just to slip the sections of the patent to the right and left. We can see that overall, the Patent #3 is an improved version to Patent #2 where this has been shown to be more experimentally feasible in causing more chondrocyte proliferation.

Implications: These patents show what exactly would have to go into a gel/resin and cultured cell pellet combination to make any idea of implanted chondrocytes to work out. The way to administer it would be relatively non-invasive through a small syringe with the loaded material going through the knee

Patent #1: Composition and method for the repair and regeneration of cartilage and other tissues (US8258117 B2) (Patent #1 link)

Patent Information:

Patent #2: Composition for repair of cartilage and bone and method for their preparation as skeletal tissue implant (EP0339607 B1) (Patent #2 link)

A composition for the regeneration of articular cartilage and bones by implantation comprising bone marrow derived chondrocytes or osteoblasts of autologous or homologous origin, or homologous committed chondrocytes, or autologous or homologous muscle fibroblast derived chondrocytes or any other progenital cells from mesenchymal origin and a biodegradable, biocompatible, biological resorbable immobilization vehicle (BRIV) adhesive glue consisiting of fibrinogen, thrombin, CaCl₂, protease inhibitor, and about 10-30% serum, characterized in that said composition contains from 80-160 x 10⁶ cells/ml of BRIV. (From Patent)

Me: Also from the same Inventor Dr. Sam Itay…

Patent #3: Compositions for repair of cartilage and bone (Patent #3 link) [Note: I have already talked about this invention in a previous post]

This is a picture of the patent idea from patent #1.