{Update: It seems that from the main website AyurvedicUrea.com, the main ingredient found in ayurvedic urea is “Dhatrumurgasiniy”. It seems this thing can only be found in Nepal. I will be doing some more research on what this plant/ compound really is.]

What I wanted to do with this post is try to prove conclusively that this new idea for height increase is either something worth looking into or just the newest craze in height increase to com along. When I typed in the words “Ayurvedic Urea Height Increase” into Google, I was surprised at what else I managed to find.

There is a Topix.com Discussion HERE…

From the first looks of it, it would appear that at least a dozen people have all said that it is a real product which worked for them. This seems great until you realize that all the people who said that the product is legitimate have their location traced back to one location, Lalitpur, Nepal. Even what we would say is american names like Bob are coming from the same place. There seems to be another person from the UK also saying it is legitimate so we have two people who are saying it works. Most of the other posters are not sure or claim it is a scam.

From AyurvedicUrea.com…

This website is the official website for the idea to increase height using ayurvedic urea. It seems that this website is based off of San Francisco from the Facebook page profile. They say on their page for scams that you should not buy “fake” ayurvedic urea from any providers from Africa or any one else EXCEPT them. So they seem to want you to only use them as a service. Hm….That makes me suspicious. When an organization is trying this hard to push out any possible competitors by claiming everyone else is a liar and scam artist, that make you wonder if they are a scam too. Something else to note is that the website seems to be based off of the Blogger Blogging Platform. That makes it seem like it is not very professional. However, I would have to concede that this website was built on a blogging platform too, WordPress. From this link HERE these guys say that they are the only people who sell the real Ayurvedic Urea. Are these sellers saying that they are the only people who can make this stuff? The website lists two other websites being fake sites selling fake ayurvedic urea however when I copy and pasted the URL domain names, I got only a standard WordPress 2011 theme with maybe 2 pages of weak content. Sites are www.buyayurvedicurea.com and www.ayurvedicurea.net. If you want to see what is on the websites, go ahead. There is almost nothing on these sites that the other site says makes them a scam. It’s Nothing. From the website there seems to be one “legitimate” sellers of the stuff. NAME: MELINA JATAMARI    CONTACT EMAIL: melinajatamari@gmail.com. Apparently she is the “only seller we have verified and authorized“. What the website does seem to do is hold the money in escrow so that the money you give will only reach them after you have tested the compound and seen its effects. The urea doesn’t seem to work on dwarves. There is research being conducted in Singapore starting around 11//23/2012 and will end in 7/23/2013. The next group of people being tested will be in Thailand. If you want to contact these people email them at support@ayurvedicurea.com. Or get in touch with some women named Sharon Stone (the same as the actress??) Here is the pricing from the website…

From a WordPress blog based website MeetMeDaily.com…

This website seems to be some form of funnel or sales page to get the person to go to the Ayurvedic Urea website. There is absolutely no scientific information on why this product would even work. There is even a Facebook page for Ayurvedic Urea located HERE. From the first look, there is over 6000 likes, and the profile website was created in 2009. The biggest discussion has around 54 comments with most of the profiles saying the product worked on them. However after I clicked on the profiles It showed that the profiles had no pictures, information, or friends. This seems to suggest that someone purposely created a few dozen fake Facebook Profiles to write up fake positive testimonials for this Ayurvedic Urea. There were real profiles who commented to the Facebook page asking how they can buy this extremely expensive product but it seems that no one has answered them back yet.

From AGRHood.com…

One of the podcast I have been listening to for the last 2 years has been Pickup Podcast which I found years ago when I was going through the phase where I was absorbing Personal Development and Self Help material like a sponge. The podcast has been traditionally focused on teaching men how to better their social skills and mindsets to improve their dating life and romantic relationships. In recent times it has moved more in the direction of how to build a stronger core and self image so it has also encompassed “self help”. About 3 years ago, I needed that skills and knowledge base because I realized my own social skills were deficient.

In the most recent “Podcast Episode” where the guys interview the infamous Tim Ferris, who wrote the insanely popular lifestyle design book “The 4 Hour Work Week”, they were discussing Tim’s latest book where he talks about how to find the simplest way to mastery the science (or art) of cooking, using only a few basic elements (ie. Knife, Spices, Cookware, etc.) and also about other ways to hack life to optimize effectiveness, productivity, and time management, something I am a junkie on. If there is one thing I am addicted to still, it is listening to interviews and podcasts where really successful people come on to discuss their strategies and methods on optimizing their life.

If you follow this episode, around the 1:04-1:06 (that is hours btw) mark Tim mentions that he has a friend who has went to China to perform gene therapy testing (or what Dave Asprey would call Bio-Hacking) on himself to see what would be the effects. Tim claims that his friend has managed to increase his weight which was already at 240 lb by another 30 lbs of muscle in 28 days! This seems to be from using gene vectors which I have only begun to get into.

Here are the 3 main genes that the friend has been experimenting on and manipulating.

1. Actin III – For fast twitching muscle fibers
2. Interleukin
3. Myostatin

So far I have already proposed at least 2 possible ways to increase height using gene therapy from changing the DNA of chondrocytes and progenitor mesenchymal stem cells. However what Ferriss’s friend is doing is something I didn’t think was even possible from using gene therapy (or at least legal).

From the Wikipedia article on Gene Therapy we realize that there are actually two types of gene therapy, 1. Somatic Gene Therapy and 2. Germ Line Gene Therapy. Somatic gene therapy is where the effects and modifications happen only on the person which was subjected to the treatment while germ line gene therapy is where the effects also has an effect and modify’s the subject’s offspring too. We are going to only focus on the first type right now and see if we can change our own bodies and not worry about what our kids and descendants will be like.

Getting back to the subject, (as the story goes) this friend went to China and somehow got his hands on some vectors from some supplier in a non-legal way and has managed to change his body at such a dramatic way in a very short time. As far as I know, there is no muscle mass increasing drugs in the market right now that can have this dramatic of an effect, even the most intense ones. Body builders who I have researched because of the link between steroid usage and potential height increase have consistently talked about the effects of some of the craziest stuff. This is at another level.

For me, this type of claim by Tim Ferriss seems to show to me that there are already people who have been successful in using illegal supplies and tried using gene therapy on themselves and gotten results. Since this happened in China (and we know that in China, anything can happen… like in Vegas) we sort of have to take this story with at least some bit of reservation. This story shows that if I (and Tyler and other genetics knowledgeable height increase seeker enthusiasts around the world) can figure out a more complete map on which genes affect the human height development (besides just HMGA2 and LIN28B), we might be able to manipulate our height by causing specific cell differentiation (and maybe even transdifferentiation) from gene vectors in less than 10 years of dedicated research.

This will be another one of those posts which will eventually turn into a section/webpage of the website which will be occasionally edited and added upon. I was not aware of just how big and many books of this type there are. When I was first doing my research, I had no idea that there was this many books all devoted to this topic. The Primary source where I found this list of books was from the “Grow Taller Step” website store section (HERE).

If you want to try out your luck and buy one of the books from the links, then that is your choice. I am not promoting these books on Amazon, only to say that they do exist. The good news for you the website visitor is that a nice number of the books below are already uploaded to the “Downloads” section of this website for you to take for free.

[Note: These books are NOT in alphabetical order, yet]

1. How to Get Taller – Grow Taller By 4 Inches In 8 Weeks, Even After Puberty! – David Taylor – (Amazon Link)
2. How to Get Taller – The Complete Exercise Guide (Grow Taller) – David Taylor – (Amazon Link)
3. How To Grow Taller: Guaranteed Increase Your Height Within 8 Weeks – Peter Douglas (Amazon Link)
4. Growing Taller Secrets: Journey Into The World Of Human Growth And Development, or How To Grow Taller Naturally And Safely. Second Edition – Robert Grand (No Amazon Link)
5. How to Naturally Increase your Height (Grow Taller Guide) – Russian Sports Authority (Amazon Link)
6. How to Grow Taller — The Amazing Secrets to Quickly and Easily Grow Taller! — Get the Respect of Being Stronger, Confident, Taller and More Attractive Today! – Mike Summers (Amazon Link)
7. Grow Taller book – Hayden Carter (Amazon Link)
8. How Can I Grow Taller: Learn How To Increase Height And How To Grow Taller Naturally And Artificially. Height Increase Tips, How To Get Taller With Yoko And More. So Is There A Way To Get Taller? Yes! – Jared D. Carlson (Amazon Link)
9. Increasing Height Through Exercise – Steven C. Cummings (Amazon Link)
10. Increase Your Height – Krishna Gopal Vikal (No Amazon Link)
11. Grow Taller – Statton, Burk, Cunningham Serrano
12. How to Grow Taller “Master Secrets to Growing at Least 4 Inches in 2 Months! – Monica Heart (Amazon Link)
13. This Tall Grow Taller and Taller – The Answer to the Fear of Height [In Japanese Language] – Aiyoshi Kawahata (Amazon Link)
14. How To Grow Taller: A Comprehensive Guide And Revolutionary Exercise Program To Make You Grow – Kanwaljit Singh Kalsi (Amazon Link)
15. Grow Taller Proven Insider Secret Tips and Techniques That Will Help You Grow (Body Image Solutions) – Dr. Jesus Serrano (Amazon Link)
16. The Most Effective Way to Grow Taller (Chinese Edition) – Yang Shu Wen (No Amazon Link)
17. Small Children, Children Grow Taller Quiz – SHI DING PING BIAN ZHU (Amazon Link)
18. Children Naturally Grow Taller (Chinese Edition) – PU XIU SHENG CAO FANG (Amazon Link)
19. How Quickly Children Grow Taller 10 cm (Chinese Edition) – GONG SUI (Amazon Link)
20. You Will Grow Taller at 23 (Chinese Edition) – Jin Yang Xiu (Amazon Link)
21. Natural Human Growing Taller Method (Modul) – Jorge Garcia (Amazon Link)
22. Gaining Height Through Exercise : 100 Straightening and Stretching Exercises to Make You Grow – Pierre Berthelet (Amazon Link)
23. How to Grow Taller Naturally with the Power of Your Mind – Joan M Rivera (No Amazon Link)
24. Grow Taller Now – Unknown (No Amazon link, source link)

Me: There is two patents I found that has the proposed ideas on how we can possibly inject dna mutated chondrocytes into the epiphysis of the femur and tibia to stimulate mesenchymal stem cells to differentiate into chondrocytes correctly.

Analysis:

For Patent 1 – Only a picture of the idea below was used. The idea as always to combine a type of gel system with growth factors in it and have extracted and regrown chondrocytes implanted in it. Then the entire piece is then implanted into a bone defect or fracture or cartilage to heal it.

For Patent 2 – we have a mixture to heal articular cartilage defects comprising of these components through implantation. There are two main pieces. In essence, it is a proliferating chondrocyte cell structure having phenotypic capability embedded in a vehicle or gel.

The first peice is the extracted and cultured chondrocytes of a certain packing density. This is bone marrow derived chondrocytes or osteoblasts of autologous or homologous origin, or homologous committed chondrocytes, or autologous or homologous muscle fibroblast derived chondrocytes or any other progenital cells from mesenchymal origin

The second part is a a biodegradable, biocompatible, biological resorbable immobilization vehicle (BRIV) adhesive glue. This is made of the following compounds

• fibrinogen (100-150 mg/ml)
• thrombin (60-90 units/ml)
• CaCl₂ (an excess of 60 mM CaCl₂.)
• protease inhibitor (selected from the group consisting of polysaccharide inhibitors, plasma protease inhibitors, and synthetic and natural non-plasma protease inhibitors)
• about 10-30% serum (selected from fetal calf serum or umbilical cord serum from the second trimester or horse serum or any combination of such serums. may optionally contain growth factors such as IGF_I, IGF_II, TGFB, PDGF, or any other growth factors that will be found to facilitate the proliferation of the cells)

The chondrocyte population is embedded in the biological glue at a concentration of between from 100,000 to 500,000 cells per milliliter of glue.

For Patent 3 – Patent #3 was written by the same guy who wrote up patent #2 and he wrote it because it turns out patent #2 had a few limitations that was later found out from experiments. It was believed that for the greatest ability in chondrocyte proliferation the best type was embryonic. However this meant the right type of cells was hard to get and there was also the problem with immune system reactions. It would turn out that the concentration limits for the chondrocyte density in gel, the thrombin, and the fibrinogen were not good in actual experimental testing. The compositions and procedures were changed. I have decided just to slip the sections of the patent to the right and left. We can see that overall, the Patent #3 is an improved version to Patent #2 where this has been shown to be more experimentally feasible in causing more chondrocyte proliferation.

Implications: These patents show what exactly would have to go into a gel/resin and cultured cell pellet combination to make any idea of implanted chondrocytes to work out. The way to administer it would be relatively non-invasive through a small syringe with the loaded material going through the knee

Patent #1: Composition and method for the repair and regeneration of cartilage and other tissues (US8258117 B2) (Patent #1 link)

Patent Information:

Patent #2: Composition for repair of cartilage and bone and method for their preparation as skeletal tissue implant (EP0339607 B1) (Patent #2 link)

A composition for the regeneration of articular cartilage and bones by implantation comprising bone marrow derived chondrocytes or osteoblasts of autologous or homologous origin, or homologous committed chondrocytes, or autologous or homologous muscle fibroblast derived chondrocytes or any other progenital cells from mesenchymal origin and a biodegradable, biocompatible, biological resorbable immobilization vehicle (BRIV) adhesive glue consisiting of fibrinogen, thrombin, CaCl₂, protease inhibitor, and about 10-30% serum, characterized in that said composition contains from 80-160 x 10⁶ cells/ml of BRIV. (From Patent)

Me: Also from the same Inventor Dr. Sam Itay…

Patent #3: Compositions for repair of cartilage and bone (Patent #3 link) [Note: I have already talked about this invention in a previous post]

This is a picture of the patent idea from patent #1.

Me: I think it is time to put the questioning of whether the hGH in the human body directly stimulated the epiphyseal plate for longitudinal growth to be answered conclusively. It does.

From article 1…

We see that chondrocytes from the tested rat’s epiphyseal plates are removed and cultured using calf serum. The thing to note is that to make the condrocyte colonies one needs the serum. There is also a strong correlation in terms that the number of colonies formed is directly proportional to the concentration of the calf serum. Overall we see that we need all three factors of

1. Number of initial seeded chondrocytes
2. Have enough 10-15% newborn calf serum
3. Having around 10-40 ng/ml of hGH

From article 2…

We see that both hGH and IGF-1 both lead to increased cloning efficiency. What is even more interesting is that IGF-1 when used after the pretreatment of the chondrocytes by GH lead to a far greater effect of cloning efficiency. The researchers concluded that …” The results of the present study show that pretreatment of hypophysectomized rats with GH, but not with IGF-I, promotes the formation of chondrocyte colonies and make the chondrocytes susceptible to IGF-I in vitro. The results suggest that GH induces colony formation by IGF-I-independent mechanisms and that IGF-I is a second effector in GH action as previously shown”

From article 3…

This study was designed to investigate whether growth hormone (GH) influences the expression of its own receptor in chondrocytes. To investigate this possibility GH-receptor mRNA was measured in cultured rat epiphyseal chondrocytes in the absence or presence of GH under various experimental conditions. The researchers concluded that “GH specifically regulates mRNA levels for its own receptor in rat epiphyseal chondrocytes by interacting with somatogenic binding sites. These findings also suggest a transcription-dependent regulatory system between the GH-receptor and the GH-receptor gene.”

Implications: It seems that GH can be used to cause cell colony formation and is the first hormone that is usually used to stimulate epiphyseal plate chondrocytes. THe IFG-1 pathway is independent of it’s pathway. It seems that the GH causes it’s own receptors to form by turning it’s own receptor genes on.

From PubMed article 1 link HERE…

Endocrinology. 1986 May;118(5):1843-8.

Growth hormone potentiates colony formation of epiphyseal chondrocytes in suspension culture.

Mol Cell Endocrinol. 1990 May 7;70(3):237-46.

Growth hormone regulation of the growth hormone receptor mRNA in cultured rat epiphyseal chondrocytes.

Me: This is one of those posts that puts ideas into one’s head on what is possible biomedically. The study shows that one can transplant epiphyseal plates into host bodies as long as it is kept vascularized. The term vascularized just means that it has blood vessels going in and out of it keeping it feed with incoming nutrients and has a way to remove the waste. One big question I have had since reading Dr. Brighton’s detailed description of the plates was exactly how the blood vessels are distributed along the layers of the plate. We know that the resting zone is the most critical since it is where everything starts and is also the true determining area for how much longitudinal growth is possible. It also has at least 2 growth factors which determine the chondrocytes to start stacking in columns when they get to the proliferative zone.

There was 4 ways the researchers were testing to see the longitudinal growth.

1. Serial roentgenograms – a time distribution of photographs made with x-rays
2. Histological examination – using microscope to analyze the cells
3. Fluorescent bone-labeling – sounds just like what it is
4. Microangiography – Radiography of the minute blood vessels of an organ obtained by injection of a contrast medium and enlargement of the resulting radiograph

Implications: This study has proved that growth plate transplantation is completely possible, as long as you keep the chondrocytes fed through vascularization.

From PubMed study link HERE… (For a copy of the Full Text PDF click HERE)

J Bone Joint Surg Am. 1984 Dec;66(9):1421-30.

Free microvascular epiphyseal-plate transplantation. An experimental study in dogs.