Adjustable Heel Lift Height Increase Silicone Shoe Insole 7 Pads, Why I Think This Product Is Horrible

Heel Lift Height Increase Silicone Shoe Insole 7 Pads

From from Ebay link HERE

I remember seeing these height increase silicone shoe insoles on Ebay and I wanted to share it with the readers. From just an initial look at the insoles, I would say that this shoewear is a horrible product. The claim is that the stacked insole has 7 layers, which all combine together to give a person a 2.75 inch increase (or 7 cm). You also have the nice option of removing and adding the insoles depending on how high and tall you want the extra height.

Here is my problem with it. Obviously anyone who buys this product wants to look taller, and be discrete about it. They would want to be as much taller as possible so they would want to use all 7 layers. However, there are very few shoes in the world which has enough space to fit the entire 7 layers, which would probably take up 50% of all the space inside any shoe. If you put all 7 layers in, there is no room left for ones’s foot.

If you look at most sneakers, boots, or dress shoes, the level where the feet’s heel touch and were the surrounding material covers is only around 2-3 inches high. This insole would push the level of where the heel of the feet would go past even that surrounding material. There is not where the feet can go. In addition, even if you did buy larger sized shoes, with taller surrounding material, you can see that the insole is pushed up to a really slanted angle at almost a 45 angle. I don’t know any human feet that is structured to be able to fit comfortably in a shoe with this type of insole inside. The back heel bone (calcanus) would have to be grinded to half of it’s volume at a plane angle to get the feet to slide into the shoes. Of course then the hassle and difficulties would be too much for just a silicone insole.

So the 3 major problems are…

1. The 7 layer insole would take up so much room inside the shoes that the feet would not be able to go in or fit.

2. The 7 layer insole would be so high that it would be so close or even higher than the surrounding erect shoe material that one can not hold the feet in place without sliding out.

3. The 7 layer insole is designed so that it is at a steep angle. There is no human feet structured that can fit in a shoe with this type of insole inside since the back bone is protruding outwards and downwards.

To solve the three problems, one would have to obviously remove at least 4 of the insoles so that the feet can fit relatively comfortably and easily into the shoes. If that is the case, then why would anyone want to buy 7 layers in the first place when it would make the most practical sense to sell what would actually work, which is probably 3-4 layers.  

 

Buying Chondrogenesis Products StemXVivo Chondrogenic Supplement, StemPRO, And Poietics

Me: I have just become aware very recently that there is at least one company where you might be able to order and get chondrogenesis raw materials which is Invitrogen. They seem to sell pretty much everything that I would want to get if I had a real laboratory to work with to test different types of growth factors to see how they would affect limb growth and limb fractures. There are stem cells, progenitors cells, osteocyte/chondrocyte differentiation mediums, and a lot of other stuff. The stuff is not allowed for personal use of course but in maybe a few years we could be able to get them for human use if we can prove in the lab in its efficacy.

Let’s see what some of the products you can find are…

For the StemPRO Chondrogenesis Differentiation Kit, you can click HERE to get to  product catalog PDF for the company Invitrogen. This also includes the STEMPRO® MSC SFM or MesenPRO RSTM Medium

The STEMPRO® Chondrogenesis Differentiation Kit Contains…

  1. STEMPRO® Osteocyte/Chondrocyte Differentiation Basal Medium
  2. STEMPRO® Chondrogenesis Supplement

Note that the “Intended Use is only for For research use only (RUO). Caution: Not intended for human or animal diagnostic or therapeutic uses.

Until I and other researchers are absolutely sure and have tested these products for safety and efficacy, this product is not to be used yet.

Note: On the right side are other products that are recommended but not supplied in the kit.

From the Lonza Group website link HERE you can get the product called Poietics which is human ADSCs which is used for chondrogenesis lab experiments.

From the RND Systems website for a product catalog PDF located HERE

StemXVivoTM Chondrogenic Supplement (100X)

Media Supplement for Human and Mouse MSC Chondrogenesis Catalog Number: CCM006 Storage: ≤ -20° C Volume: 500 μL

Product Description

The StemXVivo Chondrogenic Supplement is a media supplement for the differentiation of mesenchymal stem cells (MSCs) into chrondrocytes. All the components have been selected and optimized for human and mouse MSCs chrondrogenesis. This product does not contain antibiotics.

Intended Use

StemXVivo Chondrogenic Supplement is designed to be used with StemXVivo Chondrogenic Base Media
(R&D Systems, Catalog # CCM005) for the desired differentiation application. It may be used with other base media to differentiate MSCs depending on the experimental design of each researcher.

From Cyagen website link HERE

You can get the Mesenchymal Stem Cell Chondrogenic Differentiation Medium for about $430.

Specifications

Highlights:
– Highly effective in inducing mesenchymal stem cells into cartilage.
– Can be used for mesenchymal stem cells from various tissues/organisms.
– Packaged as a kit with Alcian Blue included.
– Batch-to-batch consistency.

Kit Components:

 Mesenchymal Stem Cell Chondrogenic
Differentiation Basal Medium
 194 ml
 Dexamethasone  20 μl
 Ascorbate  600 μl
 ITS Cell Culture Supplement  2 ml
 Sodium Pyruvate  200 μl
 Proline  200 μl
 TGF-β3  2 ml

From ScienCellOnline.com

Mesenchymal Stem Cell Chondrogenic Differentiation Supplement

Description

Mesenchymal Stem Cell Chondrogenic Differentiation Supplement (MCDS) is a medium supplement designed for differentiation of primary mesenchymal stem cells (MSCs) to an chondrogenic lineage as determined by Safranin-O staining in vitro. It is a sterile, concentrated (100X) solution. The supplement is designed as an additive for mesenchymal stem cell chondrogenic differentiation medium (MCDM, Cat. No. 7551) and should be used in conjunction with that medium.

Product Use

MCDS is for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures.

Proposed Height Increase Method Legitimized For Efficacy And Safety Through Animals Studies And Testing

This is just my own personal opinion but if we should ever come up with a real method and technique to possibly increase long bone length we should have it be first tested on animals. This is always assuming that the method is invasive in any way. If it was non invasive we can all try out ideas in our own homes with store bought products.

I propose that at some point we should get into contact certain groups of medical researchers and scientists to perform our proposed method and get it written up in a real scientific journal and paper so that our cause and endeavor is taken seriously by the scientific and medical community. There is no way for us to make our cause to be heard unless we go through some red tape and beaurocracy. If we can raise a certain amount of funding, help pay for at least 1 round of researching, and get a team of university professors to test out our hypothesis, and validate it beyond statistical testing error then I believe it would be possible to really get recognition for what we are doing.

Professors throughout the world spend more than 10% of their professional lives writing up proposals for grants to get money and funding from government and corporate organizations for their interests and research. I should know since I have worked with graduate student and have done biotech and biomedical research before. The major corporations and companies like Genentech and Biogen have the equipment and resources and they also are trying to push the edge of biological science but they won’t be wiling to put their resources for a cause which is more likely to be a failure and a bad investment into this.

 

 

NeoCart Autologous Cartilage Tissue Implant For Cartilage Regrowth And Replacement

Me: I have recently found out about this product being sold called NeoCart, an autologous cartilage tissue implant, which seems to be using the technology of cartilage regrowth for eventual surgical implantation to heal fractures. What is nice about this product is that one can just buy it. To make the NeoCart product it is “produced by seeding a type-I collagen matrix scaffold with autogenous chondrocytes and bioreactor treatment“. The implications of this product and technology is that we can see that there are already places where we can buy these cartilage implants or get their services. What might be good is if we can figure out what type of growth factors were used in the bioreactor treatment along with the implanted chondrocytes. This might give us a bigger clue on how to cause induced or injected chondrocytes into bones to increase and create a cartilage layer. 

From Histogenics website HERE

Histogenics grows the NeoCart® implant ex vivo (outside the body) from the patient’s own cartilage cells in a patented, high-pressure tissue engineering processor. This processor mimics the natural conditions experienced in the knee while walking, producing more natural neocartilage than other techniques.

Phase I trials showed improvement in function and relief of pain, with 87.5 percent of subjects with good fill at 12 months, versus 50 percent of subjects with good fill who had undergone microfracture. The NeoCart Phase II trial is complete, with 6, 12 and 24-month data trends superior to the control arm microfracture.

Advantages
NeoCart implant promises an advanced solution for joint repair to help restore a patient’s active lifestyle.

  • Starts with a patient’s own cartilage cells from a simple biopsy
  • Incorporates patented 3D matrix to protect cells and encourage growth and development of cartilage tissue
  • Results in optimally produced tissue containing both multipying cells and substantial amount of true cartilage tissue
  • Is easy to handle and implant
  • Can treat large cartilage defects
  • Uses proprietary bioadhesive for strength and biocompatibility – no suturing
  • Integrates with surrounding native cartilage

Treatment
NeoCart treatment has three phases.

Cell collection.The process begins during a short, simple arthroscopic examination when an orthopedic surgeon takes a cartilage biopsy from a non-weight bearing area of the joint. The tissue biopsy is sent to the Histogenics manufacturing facility for culturing into the implant.

Tissue production. The cartilage cells, or chondrocytes, are isolated from the cartilage and multiplied using standard tissue culture techniques. The cells are harvested, seeded into a unique 3-dimensional collagen scaffold, and cultured under exacting conditions of high pressure, oxygen concentration and perfusion.

Implant. After a few weeks, a discrete three-dimensional piece of the patient’s own neocartilage, having characteristics of maturing native articular cartilage, is sent to the physician and implanted into the defect in a simple procedure that usually takes less than an hour. Within months, the matrix remodels, the cells mature, and the cartilage integrates with the host tissue.


From PubMed study link HERE

J Bone Joint Surg Am. 2012 Jun 6;94(11):979-89. doi: 10.2106/JBJS.K.00533.

NeoCart, an autologous cartilage tissue implant, compared with microfracture for treatment of distal femoral cartilage lesions: an FDA phase-II prospective, randomized clinical trial after two years.

Crawford DC, DeBerardino TM, Williams RJ 3rd.

Source

Department of Orthopaedics and Rehabilitation, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Mail Code OP31, Portland, OR 97239, USA. crawfden@ohsu.edu

Abstract

BACKGROUND:

Despite introduction of autologous chondrocyte therapy for repair of hyaline articular cartilage injury in 1994, microfracture remains a primary standard of care. NeoCart, an autologous cartilage tissue implant, was compared with microfracture in a multisite prospective, randomized trial of a tissue-engineered bioimplant for treating articular cartilage injuries in the knee.

METHODS:

Thirty patients were randomized at a ratio of two to one (two were treated with an autologous cartilage tissue implant [NeoCart] for each patient treated with microfracture) at the time of arthroscopic confirmation of an International Cartilage Repair Society (ICRS) grade-III lesion(s). Microfracture or cartilage biopsy was performed. NeoCart, produced by seeding a type-I collagen matrix scaffold with autogenous chondrocytes and bioreactor treatment, was implanted six weeks following arthroscopic cartilage biopsy. Standard evaluations were performed with validated clinical outcomes measures.

RESULTS:

Three, six, twelve, and twenty-four-month data are reported. The mean duration of follow-up (and standard deviation) was 26 ± 2 months. There were twenty-one patients in the NeoCart group and nine in the microfracture group. The mean age (40 ± 9 years), body mass index (BMI) (28 ± 4 kg/m2), duration between the first symptoms and treatment (3 ± 5 years), and lesion size (287 ± 138 mm2 in the NeoCart group and 252 ± 135 mm2 in the microfracture group) were similar between the groups. Adverse event rates per procedure did not differ between the treatment arms. The scores on the Short Form-36 (SF-36), Knee Injury and Osteoarthritis Outcome Score (KOOS) activities of daily living (ADL) scale, and International Knee Documentation Committee (IKDC) form improved from baseline (p < 0.05) to two years postoperatively in both treatment groups. In the NeoCart group, improvement, compared with baseline, was significant (p < 0.05) for all measures at six, twelve, and twenty-four months. Improvement in the NeoCart group was significantly greater (p < 0.05) than that in the microfracture group for the KOOS pain score at six, twelve, and twenty-four months; the KOOS symptom score at six months; the IKDC, KOOS sports, and visual analog scale (VAS) pain scores at twelve and twenty-four months; and the KOOS quality of life (QOL) score at twenty-four months. Analysis of covariance (ANCOVA) at one year indicated that the change in the KOOS pain (p = 0.016) and IKDC (p = 0.028) scores from pretreatment levels favored the NeoCart group. Significantly more NeoCart-treated patients (p = 0.0125) had responded to therapy (were therapeutic responders) at six months (43% versus 25% in the microfracture group) and twelve months (76% versus 22% in the microfracture group). This trend continued, as the proportion of NeoCart-treated patients (fifteen of nineteen) who were therapeutic responders at twenty-four months was greater than the proportion of microfracture-treated participants (four of nine) who were therapeutic responders at that time.

CONCLUSIONS:

This randomized study suggests that the safety of autologous cartilage tissue implantation, with use of the NeoCart technique, is similar to that of microfracture surgery and is associated with greater clinical efficacy at two years after treatment.

PMID: 22637204    [PubMed – indexed for MEDLINE]

 

How Tall Is Yao Ming? Is His Height 7′ 5″ Or 7′ 6″?

This will be another one of those fun posts which I have always wanted to write about but never could find a platform or place to write about such a topic. Today’s post is on the real height of ex-NBA star Yao Ming. Since I have been a basketball fan, I have followed the career of this Chinese Giant to see whether a person of his size would do well in professional sports. I know that he played for the Houston Rockets for his entire NBA career after being the #1 pick from the 2002 NBA Draft. When he first arrived in the US and NBA, many people did not know what to expect from this man from a foreign nation.

Now a decade later with Yao Ming retiring, the NBA has found a huge new market to go into for its newer generation of stars, China. Every month I am hearing about how basketball stars like Lebron James, Dwyane Wade, and Kobe Byrant have been coming to China to host intercultural exchange using the sport of basketball. China is getting richer and some of the best business opportunities can be found there. The people in China are also crazy about the sport from watching super human giants jump into the air and nearly fly. I remember in the 90s with the reign of Michael Jordan that the advent of the internet had not come along yet and his popularity was just starting to reach the other nations. However, the basketball players of today have found the ability to reach kids from all the countries in the world that his airness probably would not have thoughht was even possible. I am almost positive that in another 10 years, the sport of basketball will try to sink its teeth into India, Africa, Indonesia, and many other nations around the world with a large population base.

However let’s get back to seeing how tall Yao Ming really is. Some sources say he is 7’5″ but other sources say he is 7′ 6″. In SI units that means he ranges from 2.26-2.285 meters in height, at about a 2.50 cm difference. When it comes to true human giants like Yao, there heights are a real mystery for most people. It is near impossible for a person who is even 1 feet shorter than them to guess their height correctly to within 2 inches. Since we are talking about a 1 inch difference, there is no way that most other people can judge his height accurately. A person of his height can vary very quickly in weight so I will just choose the value that is found from the official NBA website which is at 310 lb (or 140.6 kg).

Other useful information about Yao from imdb.com…

His father, Yao Zhiyuan, is 6′ 7″; his mother, Fengdi Fang, is 6′ 3″ and was captain of the Chinese national women’s basketball team.

According to the Houston Rockets strength and conditioning coach, Anthony Falsone, he is still growing. Falsone says Yao was 7′ 5″ tall without shoes on (7′ 6 1/2″ with shoes) in October of 2002, but that by September of 2004, he had grown to 7′ 5 3/4″ in height barefoot, and to 7′ 7 1/4″ in height with shoes on.

At the 2004 Summer Olympic Games in Athens, Greece, he was listed as having a 7′ 5″ wingspan, a 9′ 8″ standing reach, and a size 18 shoe US.

His team media guide profile in China, stated that Yao had a 26 inch vertical leap, jumping from a standstill. However, Yao himself has said since then that two foot injuries he suffered since that time, lowered his vertical leap after this by about 4 to 6 inches.

First these are the sources that say Yao Ming is 7′ 5″ in height (2.2606 meters)

1. imdb.com  – he is actually listed at 7′ 5.5″ or 2.27 meters tall here. from the imdb link this quote is taken “According to the Houston Rockets strength and conditioning coach, Anthony Falsone, he is still growing. Falsone says Yao was 7′ 5″ tall without shoes on (7′ 6 1/2″ with shoes) in October of 2002, but that by September of 2004, he had grown to 7′ 5 3/4″ in height barefoot, and to 7′ 7 1/4″ in height with shoes on.

Me: The issue for me was that Yao came into the NBA league when he was 22, at least that was the age the Chinese government listed him as, and being able to still grow another 1 inch when one is at age 22-23 is really incredible. But then, this is a giant man with height in his genes and family so maybe he did grow.

2. Urban Dictionary – just for humor

3. CelebHeights.com – quote from site: Either gets listed at 7ft 5 or 6. Shawn Bradley, another giant of the court has been quoted as saying: “He’s not as tall as me. If he’s 7-6, I’m 7-8”. Yao has stated “I’m 7-6” before.

4. NBA Chicago Bulls Predraft Measurements – listed at 7’5″ without shoes and 7′ 6.25″ with shoes with 7′ 4.75″ wingspan.

5. USBasket.com

6. TheTallestMan.com

Next, these are the sources that say Yao Ming is 7′ 6″ in height (2.286 meters)

1. Wikipedia

2. NBA.com

3. Basketball-Reference.com

4. Yahoo! Sports

5. imdb.com – quote from the profile page: At a height of 7′ 6″, he is tied with Shawn Bradley, for the distinction of being the tallest player in the NBA.

6. HeightCeleb.info

7. TheTallestMan.com – Yao is compared to people like Hakeem Olajuwon, Michael Jordan, and Dikembe Mutombo and half of the people says he is 7′ 6″.

If you would like to do something fun, you can follow his twitter feeds HERE which is his real twitter profile.

Here is a picture I found of Yao from the 2008 Olympics Chinese Basketball Team (source HERE).

 

What I see is one of the most clear examples of Yao being at least 7′ 5″. To Yao’s right and left stands Yi Jianlian and Wang Zhizhi. While Yi Jianlian has been listed at 7’0″ in the NBA directory (HERE) his predraft measurements (HERE) show that he is actually 6′ 11″ without shoes, 7′ 0.25″ with shoes, and has a 7′ 3.5″ wingspan. On the site Asia Basketball (HERE) Yi has been listed at 2.12 meters tall which seems very reasonable since in the picture he looks almost the same height at Wang Zhizhi if not just slightly shorter.

With Wang Zhizhi he has been listed at 7′ 1″ (2.16 m) in the NBA when he first was introduced to the US but in more recent year his height is labeled at 7′ 0.25″ or 2.14 meters which seems very reasonable (Wikipedia). Other sources (HERE) list him as just 7′ 0″. Asia Basketball lists him at 2.15 meters (HERE).

With most people’s head, the tip of the top of their head to the middle level of their eye level is around 4-5 inches. For people with larger heads or larger foreheads like Yao, the top of his height to the middle of his eye level is probably 5 inches if not more. We can see that both Yi and Wang has their head below the eye level of Yao’s and probably about 1 inch  below the center of Yao’s eye level. This would definitely put Yao at the 7′ 6″ range which many basketball analyst have said about him.

As for Shawn Bradley, the ex-NBA player who has been most compared to Yao in height, Bradley was once measured on 60 minutes by Andy Rooney to have been actually 7′ 6.25″ with a rather error prone measuring tape. In most pictures of the two, Shawn does look slightly taller than Yao but maybe only by 0.25-0.5 inches at most. In the picture on the right shawn does look maybe 1 cm taller than Yao. You can clearly see the floor and their overall sneakers look about the same giving the same amount of shoe height. Their postures are about the same. They are standing relatively straight up with their back almost against each other. What is clear is that Bradley’s eye level is probably 1 inch higher than Yao’s but Yao does have a wider and thicker head than Shawn.

 

 

 

 

 

Now here is a picture of Yao with Dikembe Mutombo (source HERE) who has been listed at 7′ 2″ in his NBA career although some people have said that Dikembe was measured at 7′ 1.25″ without shoes when he first came into the League. No matter how I change the angles, Yao still looks at least 4.5-5 inches taller than Mutombo if not more. I am willing to admit that Dikembe is stnding slightly further away from the camera and his feet is at a larger angle.

 

 

 

 

 

 

 

 

 

 

 

From photo bucket (source HERE)we see on the right of Yao compared to Shaq who we have almost concluded is the 7′ 1″ height he has always claimed. From this picture we can see that Yao’s eye level is right where Shaq’s head top is. Yao’s head it slightly crooked with his neck twisting around but we can say that Yao is at least 4.5 inches taller than shaq.

From all these pictures I am going to make a final conclusion on Yao’s height. Some of the more reliable resources have always said that Yao is 7′ 5″ but the sources from the US and NBA sources say he is 7′ 6″. From my experience, I know that the NBA often pads the height of its players by at least 1 inch to make themselves look bigger. Players who were listed at 6′ 8″ goes up to 6′ 9″. What is very noticeable is that most of the player who are extremely tall like Shaq and Yao, they don’t lie or exaggerate their height since they are already tall enough. With Yao, I would say that he is probably 7′ 5.5″-7′ 5.75″ inches at the end of the night after the spinal disks have compressed. When Yao gets out of the bed in his morning, height I would guess he could be 7′ 6.25″-7.6.5″ in height. I know that for myself, my height ranges from 6’0″ when I get out of bed to 5′ 11.25″ (or even slightly lower) when I go to bed. With Yao and his body, his height should be very more varied. Since his height fluctuates so much and does probably dip down to even 7′ 5.5″ (but no lower) during the day, that was probably when the doctors made their measurements. When he was measured in the morning, he was taller. If we combine all the height variation, I would guess that Yao can be considered 7′ 6″ or just slightly less at 7′ 5.75″ than that overall since I am quite positive that he does go over the 7’6″ height limit for at least the early part of the day after waking up. That is why we can and most people do claim that Yao is 7′ 6″ tall.

A Height Increase Journal To Write Down My Research Notes

One thing I have been doing is getting a journal so I can write down notes from the research I’ve been doing. So far I have kept track of

1. Different types of growth factors on chondrogenesis and osteogenesis.

2. The dimensions and values of the mechanical and material properties of the bone in every single area.

3. The protein/hormone signaling pathway map.

4. Food and supplements which have known height increasing properties.

5. Major genes that are involved in endochondral ossification .

6. Anatomy figures of the muscles and ligaments around the bone.