Tallest Male Actors In Movies And Television

Me: This is another post in a long series which showcase the tall people in different professions around the world. Here is a list of the tall actors that have been on the big screen whether in the blockbuster movies or the television series. I find it fun to find out how tall some actors and actresses are since I wanted to compare them to real life. They all seem to look a lot bigger on the screen than in real life. I also wanted to add to the list a little.

1. Wilt Charmberlain at 7′ 1″ – In Conan and the Destroyer

2. Kevin Peter Hall at 7′ 2″- the actor who played the Predator in first Predator movie

3. Anthony Robbins at 6′ 7″ – In “Shallow Hal”   (suffered from Pituitary Gigantism)

4. Calvin Lane at 7′ 6″- in an episode of “Walker Texas Ranger”

5. Igor Vovkovinskiy at 7′ 8″ – in movie “Hall Pass”

6. Charles Richard Moll at 6′ 8″ –  as baliff on NBC sitcom Night Court from 1983 to 1992

7. Christopher Lee at 6′ 5″ – for Count Dracula and Count Dooku.

8. John Cleese at 6′ 5″ – for James Bond Q and many others over the years.

9. Patrick Ewing at 7′ 0″, Shawn Bradley at 7′ 6″, Charles Barkley at 6′ 6″, Larry Johnson at 6′ 5″, and Michael Jordan at 6′ 6″ – on Space Jam

10. Kevin Durant at 6′ 9″ – in movie “Thunderstruck”

11. Steven Seagal at 6′ 6″ – for Under Siege series

12. Dolpha Lungren at 6′ 5″ – Rocky IV and recent Expendables movies

13. Semmy Schilt at 6′ 11.5″  – In one of the Transporter movies

14. Lou Ferrigno at 6′ 5″ – “Hulk” impersonation

15. Tony Dodd at 6′ 5″- “Final Destination” series

16. Tommy ‘Tiny’ Lister at 6′ 5″ – Known for playing in the role of gangster and/or thug

17. Jeff Goldblum at 6′ 4″ – Jurasic Park

18. James Avery at 6′ 5″ – Uncle Phil on “Fresh Prince of Bel Air”

19. Vince Vaughn at 6′ 5″ – “Wedding Crashers”

20. David Hasselhoff at 6′ 4″ – Baywatch and TV personality

21. Rick Fox at 6′ 7″ – “Single Ladies”

22. Penn Jillete at 6′ 6″-6′ 7″- Magician and TV speaker

23. Ryan Stiles at 6′ 6″ – “Drew Cary Show” and “Two and Half Men”

24. Vincent Schiavelli – at 6′ 6″ – “Batman”    (suffered from Marfan’s Syndrome)

25. Michael Clarke Duncan at 6′ 5″ – For “The Green Mile”

26. Joe Manganiello at 6′ 5″ – For “Spider Man”

27. Hulk Hogan at 6′ 5″ – Wrestling

28. Stephen Fry at 6′ 5.5″ – For recent Sherlock Holmes movie, a very long list of work associated

29. John Lithgow at 6′ 4″- “Shrek” voice and 3rd rock from the sun

30. Adam Baldwin at 6′ 4″ – “Chuck” series

31. Jason Segel at 6′ 4″ – “How I Met Your Mother” and “Freaks and Geeks”

32. Jason Momoa at 6′ 4″ – for “Baywatch” and and Conan Movie

33. Rory McCann at 6′ 6″ –

34. Kevin Durand at 6′ 6″ – “Wolverine” Movie, “Legion”, “Robin Hood”

35. Ralf Möller at 6′ 6.5″ – Conan, The adventurer series

36. Ray Stevenson at 6′ 4″ – Rome TV series

37. Liam Neeson at 6′ 4″ – Schindler’s List

38. Daniel Cudmore at 6′ 7″ – X-Man: The Last Stand

39. Jack O’Halloran at 6′ 6″ – was in a few Superman movies

40.

(Note: The next list was written by a person names Stian Nielson from the IMDB website. link of the source list is located HERE)

Tall people

by Marshmallow97 created 1 month ago | last updated – 1 month ago
1. André the Giant
Actor, The Princess Bride
When Andre The Giant challenged Hulk Hogan for the WWF World’s Heavyweight Wrestling Championship of The World at WrestleMania III in 1987, he hadn’t lost a single’s match since 1971. His 3,000 plus winning streak was ended when Hogan picked up the 7 foot tall and 500 pound Giant and body slammed him for the pin…
“ Height: 7′ (2.13 m) ” – Marshmallow97   (Note: Andre’s Height has been reported between 7′ 0″ – 7′ 4″)
2. Brad Garrett
Actor, Finding Nemo
Standing 6 feet 8-1/2 inches tall, Garrett grew up in Woodland Hills outside of Los Angeles. His father was a hearing aid specialist working in geriatrics and his mother was a housewife. Garrett spent a whopping six weeks at UCLA before going into stand-up comedy full time. He began performing his act at various Los Angeles comedy clubs…
“ Height: 6′ 8½” (2.04 m) ” – Marshmallow97
3. Brian Posehn
Actor, Fantastic 4: Rise of the Silver Surfer
“ Height: 6′ 6¾” (2.00 m) ” – Marshmallow97
4. Bubba Smith
Actor, Police Academy
The athletically gifted 6′ 7″ Charles Aaron “Bubba” Smith played defensive end / defensive tackle for the National Football League’s Baltimore Colts (1967-1971), Oakland Raiders (1973-1974), and Houston Oilers (1975-1976). After the conclusion of his football career, Smith moved into a TV & film career…
“ Height: 6′ 7″ (2.01 m) ” – Marshmallow97
5. Carel Struycken
Actor, Men in Black
Carel Struyken was born in the Hague, The Netherlands. When he was four years old his family moved to Curacao, an island in the Caribbean. At age sixteen, he returned to his country, where he finished high school. He graduated from the directing program at the film school in Amsterdam, following which he did a year at the American Film Institute in Los Angeles…
“ Height: 7′ (2.13 m) ” – Marshmallow97
6. Dalip Singh

Actor, The Longest Yard

“ Height: 7′ 2″ (2.18 m) ” – Marshmallow97

7. Dennis Rodman
Self, The Rodman World Tour                    (Note: Also in movie with Jean Claude Van Damme “Double Team”)
“ Height: 6′ 7″ (2.01 m) ” – Marshmallow97
8. Glenn Jacobs
Actor, See No Evil
“ Height: 6′ 8½” (2.04 m) ” – Marshmallow97
9. James Cromwell

Actor, The Green Mile

Born in Los Angeles but raised in Manhattan and educated at Middlebury College and Carnegie Tech, James Cromwell – the son of noted film director John Cromwell – studied acting at Carnegie-Mellon. He went into the theater (like both his parents) doing everything from Shakespeare to experimental plays…
“ Height: 6′ 7″ (2.01 m) ” – Marshmallow97
10. Kareem Abdul-Jabbar
Self, BASEketball      (Note: Also with Bruce Lee in Game Of Death)
Legendary US NBA basketball player with the Milwaukee Bucks (1969-1975) and the Los Angeles Lakers (1975-1989), the 7′ 2″ Kareem Abdul-Jabbar (born Lew Alcindor) has made numerous guest appearances on US TV shows including Man from Atlantis, 21 Jump Street, Tales from the Darkside and Scrubs. However…
“ Height: 7′ 2″ (2.18 m) ” – Marshmallow97
11. Kevin Nash
Self, TNA Impact! Wrestling
Kevin Nash has appeared in Paramount Pictures’ “The Longest Yard” (dir. Peter Segal) with Adam Sandler, Chris Rock and Burt Reynolds, in Marvel Comics’/Artisan Entertainment’s “The Punisher” (dir. Jonathan Hensleigh) opposite John Travolta and Thomas Jane, and as Bass Armstrong in “DOA: Dead or Alive” (dir…
“ Height: 6′ 10″ (2.08 m) ” – Marshmallow97
12. LeBron James
Self, More Than a Game
“ Height: 6′ 7½” (2.02 m) ” – Marshmallow97
13. Magic Johnson
Self, Magic and Bird
“ Height: 6′ 9″ (2.06 m) ” – Marshmallow97
14. Marnix Van Den Broeke
Actor, The Deaths of Ian Stone
“ Height: 6′ 7″ (2.01 m) ” – Marshmallow97
15. Matthew McGrory
Actor, Big Fish
“ Height: 7′ 6″ (2.29 m) ” – Marshmallow97
16. Nathan Jones
Actor, Troy
Nathan Jones rose upon the world strongman scene in 1995 and showed promise to become perhaps the top competitor in the world. At 6′ 11″ and 360 lbs., the giant Australian known as Megaman was an imposing sight and used his great size and strength to place high in the World Musclepower Championships…
“ Height: 6′ 11″ (2.11 m) ” – Marshmallow97
17. Ned Rolsma
Actor, Arrivederci, Fiero                (Note: Was in “How I Met Your Mother” as one of the actor’s brother)
“ Height: 7′ (2.13 m) ” – Marshmallow97
18. Paul Wight
Actor, The Waterboy
“ Height: 7′ (2.13 m) ” – Marshmallow97
19. Peter Mayhew
Actor, Star Wars
Peter Mayhew was born on May 19, 1944 in Barnes, London, England. Now residing in Texas, this former resident of Yorkshire, England, was working as a hospital attendant at the King’s College Hospital in London when film producer Charles H. Schneer saw his photo, literally standing above the crowd around him…
“ Height: 7′ 1¾” (2.18 m) ” – Marshmallow97
20. Richard Kiel
Actor, The Spy Who Loved Me
Towering 7′ 2″ tall actor who has cornered the market on playing giants, intimidating henchman, bayou swamp monsters and steel toothed villains! Kiel worked in numerous jobs including as a night club bouncer and a cemetery plot salesman, before breaking into film & TV in several minor roles in the late 1950s / early 1960s…
“ Height: 7′ 1½” (2.17 m) ” – Marshmallow97
21. Robert Maillet
Actor, Sherlock Holmes
A French Canadian from rural New Brunswick, it was clear from an early age that Robert would be a very big boy. In the first grade he stood taller than his teacher and that made him awkward and a bit shy, so growing up he took shelter in his own dreams. One of those dreams was to become a professional wrestler…
“ Height: 7′ (2.13 m) ” – Marshmallow97
22. Shaquille O’Neal
Self, After the Sunset
Shaquille O’Neal is regarded as one of the most dominant athletes and arguably the most gregarious personality in sports history. He wrote an autobiography (Shaq Talks Back), preserves an online presence for his fan base and produced a number of albums (Biological Didn’t Bother, Shaq-Fu: Da Return, etc.)…
“ Height: 7′ 1″ (2.16 m) ” – Marshmallow97
23. Stephen Merchant
Writer, The Office
“ Height: 6′ 7″ (2.01 m) ” – Marshmallow97
24. Ted Cassidy
Actor, Butch Cassidy and the Sundance Kid
Ted Cassidy was born in Pittsburgh, Pennsylvania and raised in Philippi, West Virginia. He was a well respected actor who portrayed many different characters during his film and television career. His most notable role was Lurch, the faithful butler on the television series The Addams Family. His most memorable dialogue as Lurch would be…
“ Height: 6′ 9″ (2.06 m) ” – Marshmallow97
25. Torsten Voges
Actor, The Big Lebowski
Torsten was born 1962 in Germany. He studied acting in Germany and at ACT in San Francisco. Before he came to live in the US, he worked as an actor in one of the biggest repertory companies in Germany. His parents were both lawyers. His 23 year old daughter Lena studies Psychology in Vienna. Torsten now lives with his wife, Ariana Weil, in Los Angeles.
“ Height: 6′ 9″ (2.06 m) ” – Marshmallow97
26. Tyler Mane
Actor, X-Men
“ Height: 6′ 9″ (2.06 m) ” – Marshmallow97

Tallest Living Females In The World – A Height Listing

This post is for information and resources reasons only. No information on height increase is posted here. All of the names and listing was actually found from the website Tallpeople.com (source HERE). This is not my information but a reprint since I thought it was nice information to know and have on this website. Just another resource to use and have around.

The Tallest Women

This is a list of the tallest living women in the world, 6’9″ (205cm) or taller.

236cm (7 Feet 9 Inches)

Defen Yao [Nationality: China, Born: July 15, 1972]


225cm (7 Feet 5 Inches)

Maria Feliciana Santos [Nationality: Brazil, Born: 1945]

7 Feet 1 Inch  (maybe actually be 7 Feet 3 Inches)

Urmila Kumari Chaudhari 


213cm (7 Feet 0 Inches)

Uljana Semenova [Nationality: Latvia, Born: March 9, 1952]

Lyuba Shilo


210 centimeters (6 Feet 11 Inches)

Marvadene Anderson

Tanya Angus

Gwen Bachman

Alana Renaud [Nationality: USA, Born: 1980]

Gitika Srivastava


209 centimeters (6 Feet 10 Inches)

Zorana Todorovic [Nationality: Serbia, Born: December 30, 1989]


208 centimeters (6 Feet 10 Inches)

Ellen Bayer [Nationality: USA, Born: 1968]

Suzy Bendegue

Zainab Bibi

Malee Duangdee

Jaana Kotova

Elena Kravchenko [Nationality: Belarus, Born: 1979]

Li Liu

Silvia Mesa [Nationality: Spain, Born: 1980]

Jessica Pardoe

Dharshani Sivalingam

Darina Yegerova

Ebru Nur Ozyilmaz


206 centimeters (6 Feet 9 Inches)

Nelly Alisheva (Fonova) [Nationality: Russia, Born: 1983]

Meme Besnoin [Nationality: USA, Born: 1987]

Marina Burmistrova [Nationality: Russia, Born: February 3, 1974]

Allyssa DeHaan [Nationality: USA, Born: 1988]

Antje Dethloff

Ekaterina Gamova

Elisane Silva

Suzy Gyarfash

Lindsay Hayward [Nationality: USA, Born: 1987]

Kathleen McIntyre

Lyubovi Pascalenco

Oleksandra Prystupa

Wang Ting

Connie Waikle

Wei Wei

Caroline Welz [Nationality: Germany, Born: 1986]
[Biography, Discussions, Photos, Links]

Ugyur Yushaguli


205 centimeters (6 Feet 8 1/2 Inches)

Young-Hee Kim

Yulia Merkoulova

Haixia Zheng

Rambolina

Ekaterina Lisina


Other Notable tall women

204 centimeters (6 Feet 8 1/2 Inches)

– Kristina Alminaite (Lithuania)
– Milena Boteva (Bulgaria)
– Sarah Foley (UK)
– Katarina Gaertner (Germany)
– Eva Giauro (Italy)
– Anna Kajalina (Estonia)
– Sylvia Klemmt (Germany)
– Martine Lefebvre (France)
– Rose-Marie Scheffler (France)
– Svetlana Singh (India)

203 centimeters (6 Feet 8 Inches)

– Kylee Ballensky (USA)
– Rita Besa (Zambia)
– Vasso Beskaki (Greece)
– Branka Bogunovic (Serbia)
– Elizabeth Cambage (Australia)
– Kristina Cesnaviciute (Lithuania)
– Kelly Ditto (CA, USA)
– Anne Donovan (USA)
– Katie Feenstra (MI, USA)
– Heidi Gillingham-Jackson (USA)
– Barbara Hartman Lynn (USA) – 203cm (6-8)
– Anke Hillebrand (Germany) – 203cm (6-8)
– Caroline Huttula (Sweden) – 203cm (6-8)
– Julia Kiseleva (Uzbekistan) – 203cm (6-8)
– Dominique Luijckx (Netherlands) – 203cm (6-8)
– Charlotte Lusschen (USA) – 203cm (6-8)
– Joyce Maddox (USA) – 203cm (6-8)
– Elena Matveeva (Ukraine) – 203cm (6-8)
– Christa Morriss (USA) – 203cm (6-8)
– Agnes Nemeth (Hungary) – 203cm (6-8)
– Lindsay Prewitt (USA) – 203cm (6-8)
– Rhonda Smith (USA) – 203cm (6-8)
– Maria Stepanova (Russia) – 203cm (6-8)
– Amanda Stringer (USA) – 203cm (6-8)
– Lindsay Taylor (USA) – 203cm (6-8)
– Olga Zhuzhgova (Russia) – 203cm (6-8)

202 centimeters (6 Feet 7 1/2 Inches)

Olga Potashova (Russia)
Katja Bavendam (Netherlands)
Tracey Braithwaite (Australia)
Razija Brcaninovic-Mujanovic (Bosnia)
Eun-Ju Ha (South Korea)
Svetlana Rodionova (Russia)
Danila Silveira de Mendonca Fabbri (Brazil)
Isis de Melo Nascimento (Brazil)
Pascale van Roy (Belgium)

Notes: (Written by the other writer of course)
There are a few criteria for this list.
1) Only women whose heights are verifiable to be true will be added to the list. People whose height cannot be verified (or hoax) will be listed at the bottom with an asterisk denoting the lack of verification.
2) Women whose height may have decreased due to their age will be denoted as such. We will try to list the actual height in the list, with a side note for her decrease in height. A few of the height statistics come from sources whose claims of height may be different due to conflicts of interest. These stats are denoted as such.

If you know of any information which could help improve this list, reply to this thread to add more sources and verifications.

———————————————–

Here is another list of the tallest women in History. Note that some of the women on the list are no longer living. I found the list from the Top20List.com website link HERE.

1. Trijntje Keever, 8’4.4″, 255.0cm

The oldest and tallest woman in recorded history. She lived from 1616 to 1633.

2. Zeng Jinlian, 8′ 2″, 248.9 cm   (Most sources she would be 8′ 1″ if corrected for spinal curvature)

Zeng was the tallest female ever recorded in medical history. She passed away in 1982.

3. Yao Defen, 7’8″, 233.7cm

Her gigantism is due to a tumor in her pituitary glad which I believe releases the HGH (Human Growth Hormone). There were disputes about who was taller – Yao or Sandy.

4. Sandy Allen, 7’7″, 231.1cm

Recognized as the tallest woman during her life according to Guinness World Records. She passed away in August 2008

5. Maria Feliciana Santo, 7’5″, 226.1cm

6. Margo Dydek, 7’2″, 218.4cm

Dydek is the tallest female basketball player ever to set foot on that court.

7. Svetlana Singh, 7’2″, 218.4cm (actually been documented by thetallestman.com to be actually around 6′ 8″)

She is not just very tall herself, but she has the tallest baby as well.

8. Zainab Bibi, 7’2″, 218.4cm

Zainab Bibi is now settled in the UK after getting an asylum their on grounds that her height is making her life very hard in Pakistan

9. Urmila Kumari Chaudhari, 7’1″, 215.9cm

I believe she is the tallest person in Nepal

10. Lyuba Shilo, 7’0″, 213.4cm

Lyuba is Ukraine’s tallest woman

11. Ulyana Semenova, 6’11”, 210.8cm

She used to be the tallest basketball player in her time.

12. Gwen Bachman, 6’11”, 210.8cm

13. Gitika Srivastava, 6’11”, 210.8cm

14. Zorana Todorovic, 6’10.5″, 209.6cm

15. Ellen Bayer, 6’10”, 208.3cm

16. Jaana Kotova, 6’10”, 208.3cm

Yet another tall basket ball player.

17. Silvia Mesa, 6’10”, 208.3cm

One of the tallest basket ball players

18. Elena Kravchenko, 6’10”, 208.3cm

She is at least a head taller than everyone

19. Amazon ISIS, 6’9.5″, 207.0cm

20. Darina Yegerova, 6’9.5″, 207.0cm   (was found by guinness records to be around 6′ 7″)

She holds the record for the world’s longest legs

World Tallest Volleyball Players

I wanted to put another post to showcase the people who have been listed to be among the tallest in the world who has played the sport of Volleyball, nationally, professionally, or locally.

Note: I am sure that there are probably more guys who are in the 2.10 meters to 2.14 meters range who play Volleyball that I have not found or listed on this post. I know that there are some Dutch and Swedish Men’s Volleyball teams where middle blockers are up to 6′ 11″ in height. 

For Females

From Wikipedia….

Nelly Alisheva – She is a middle blocker from Russia who currently plays for Omichka Omsk in the Russian Super League. Nelly was born on born December 20, 1983 in Lipetsk and she stands  2.05 m (6 ft 9 in). Nelly Alisheva (Russian: Нелли Алишева; born December 20, 1983 in Lipetsk) is a Russian volleyball player. She is 2.05 m (6 ft 9 in) tall and plays as center. She plays for Dinamo-Yantar Team since 2003.She is the tallest of left-handed women of the world (The second tallest is Valentina Borrelli).

Yekaterina Aleksandrovna Gamova (Russian: Екатерина Александровна Гамова) (born October 17, 1980 in Chelyabinsk) is a Russian volleyball player. She was a member of the national team that won the gold medals at the 2006 and 2010 FIVB Women’s World Championships, and the silver medal in both the Athens 2004 andSydney 2000 Olympic Games. She is 2.02 m (6 ft 8 in) tall with EU size 49 feet, making her one of the tallest female athletes in the world.[2][3] Her role is outside hitter/opposite.

For Males

Renan Buiatti: 2.12m. tall volleyball player. Renan born in Brazil and have 22 years old. Some media say 2.17m other 2.16m

Wilt Chamberlain – 7′ 1″ (2.16 meters) – President of volleyball association. Chamberlain played volleyball in the short-lived International Volleyball Association, was president of this organization, and is enshrined in the IVA Hall of Fame for his contributions.

From Wikipedia….

Kay van Dijk (born June 25, 1984 in Oosterbeek, Gelderland) is a volleyball player standing at 7′ 0.75″ (2.15 meters tall) from the Netherlands, who represented his native country at the 2004 Summer Olympics in Athens, Greece. There he ended up in ninth place with the Dutch Men’s National Team. He is a member of South Korean Gumi LIG Greaters volleyball team since August of 2008.

Dmitriy Muserskiy (born 1988 in Makiivka, Ukraine)[1] is a Russian volleyball player, who competes for Belogorie Belogorod and the national team. He has competed at the 2012 Summer Olympics, where Russia got to the final and won against Brazil. He won 31 points in that match and was Russia’s best player.

Aleksey Valerevich Kazakov (Russian: Алексей Валерьевич Казаков, born May 18, 1976) is an Russian volleyball player. He was born in Naberezhnye Chelny, Tatar Autonomous Soviet Socialist Republic. Kazakov was a member of the national team that won the bronze medal at the 2004 Summer Olympics in Athens. Four years earlier in Sydney he gained the silver medal. He is 2.18 metres tall, making him one of the tallest athletes in the world. (other sources say he is 2.16 meters tall)

World Tallest Female Models Amazon Eve And Elisany Silva

Continuing on with a tradition of finding the tallest people around the world, I present today the tallest female models in the world. In certain professions like basketball, volleyball, and modeling the factor of height does play a major role. For modeling, the people in the industry state that people who have long, tall thin bodies seem to be able to make most type of dress and clothing look good on the model who has the right body shape. I don’t know anything about modeling myself but I would guess modeling is based on looking good and people in general assume that being taller means being more attractive.

For a long time the title of the tallest female model in the world went to a California resident named Amazon Eve who stood a little over at 6′ 8.5″ (or 2.05 meters) tall. (source link HERE) She apparently was trained to be a personal trainer but in recent years she has developed a lot of popularity on the internet for her pictures which makes her look ever bigger. Now a large percentage of her income comes from modeling gigs and she is very proud and happy with her height.

That title recently appears to have to be given up to the Brazilian native Elisany Silva who stand at 6′ 9″ (or 2.06 meters) tall. (source link HERE) I had written a post about Elisany before who I featured as a contender for the title of the world’s tallest teenager. At the time of this writing (2012) Elisany would be age 16 or 17. However, the cause of the great height of these two female models are not the same. Elisany has been diagnosed with gigantism which is from a pituitary tumor issue while it has not been confirmed that Eve has her size from any form of disorder.

A Korean Herbal Supplement Mixture To Possibly Increase Height (From HeightQuest.Com)

Me: I was looking through the posts on Height Quest and I found a comment left on one of the posts where the person linked to a post which showed that apparently the Koreans have been giving kids with stunted growth a type of herbal mixture to accelerate their growth. The compounds and active ingredients appear to have been found to be extracts of Astragalus membranaceusPhlomis umbrosa and Eleutherococcus senticosus. The marketed product name is HT042 which comes as a sort of supplement taken orally.  

From a research point of view, the supplement HT042 has no oestrogenic properties. It seems to increase the numeber of IGF-1 and IGF-BP3. Rats given the supplement seemed to grow at 50% faster rate than the controlled group of rats. This supplement at this time can only be obtained with a doctor’s prescription. 

. The link to the actual article is located HERE. The HeightQuest Post was entitled “Can LSJL Work On Adults?”

Korean herbal supplement HT042 makes bones longer 

Traditional herbalists in Korea treat children whose growth is stunted with extracts ofAstragalus membranaceusPhlomis umbrosa and Eleutherococcus senticosus. A mix containing these herbs is now marketed in Korea as HT042. Pharmacologists from Kyung Hee University will soon publish the results of an animal study in which young rats grew one and a half times as fast when given HT042 as a supplement.

The Koreans published an article two years ago about the growth effects of HT042. [J Med Food. 2010 Dec;13(6):1376-84.] They gave the extract to 3-week-old female rats for four days and found that HT042 boosted the rats’ growth. The combination of astragalus, Phlomis umbrosa and Siberian ginseng boosted the activity of IGF-1 in the growth plates of the bones.

In the article that will be published soon in Phytotherapy Research the Koreans repeated their experiment, but gave rats the supplement for three weeks. Again female rats aged three weeks were given a mixture of alcohol extracts of Astragalus membranaceusPhlomis umbrosa and Eleutherococcus senticosus in a ratio of 31.2:26.5:42.3. The researchers gave the rats the supplements orally twice a day. The animals were given 100 mg HT042 per kg bodyweight per day. The human equivalent of this dose would be about 16 mg per kg bodyweight per day.

The researchers used two control groups. One group was given nothing [Control], the other was given a daily injection of 20 mcg human growth hormone [rhGH] per kg bodyweight.

The figure below shows that the supplement increased the concentration of IGF-1 and – to a lesser extent – the ‘good binding protein’ IGF-BP3 in the growth plates in comparison with the control groups. IGF-BP3 transports IGF-1 without reducing the activity of the growth factor. The bigger the clumps, the more IGF-1 and IGF-BP3.

RZ = resting zone; PZ = proliferative zone; HZ = hypertrophic zone. The length growth of the bones actually takes place in the hypertrophic zone.

Korean herbal supplement HT042 makes bones longer

Korean herbal supplement HT042 makes bones longer

The IGF-1 concentration in the blood also rose.

The table below shows that the rats in the control group grew about 34 cm. The rats in the HT042 grew 52 cm. The experimental group animals grew one and a half times as fast as a result of taking the supplement.

Korean herbal supplement HT042 makes bones longer

The researchers also looked at whether HT042 also has oestrogenic properties. Oestrogen supplementation may increase the aging of growth plates, so that growth in length stops. However the Koreans found no effects on the rats’ reproductive organs and therefore conclude that HT042 contains no oestrogenic components.

“Together, these results suggest that HT042 promotes cell proliferation and bone growth at the epiphyseal plate without oestrogenic activity”, the researchers conclude. “HT042 might be helpful in improving the short stature of children before the pubertal growth spurt.”

Yakult co-financed the study.

Whether it’s sensible to give a supplement like HT042 to children? We have our doubts. Not enough is known yet about side effects. In Korea HT042 is only available with a doctor’s prescription.

Source:  Phytother Res. 2012 Mar 3. doi: 10.1002/ptr.4642. [Epub ahead of print].

Composition for Increasing Body Height Using Guanyl Cyclase, A Gene Therapy Height Increase Invention

Me: This is the first type of invention I have ever found which shows that people have already found out how to possibly increase stature by using gene therapy. This is real. It seems the Guanyl Cyclase B activator somehow increase the cartilage in the subject’s body. Most of the technical material on genetics is over my head at this time. There is no way at this time that I can explain it as well as I hope to. This method appears to show that the technology is already available to have genetically engineering babies who are modified to be taller and bigger than the original genetic material. 

The patent was found from the link HERE.

This invention provides a composition for increasing a body height of a patient with short stature or an individual other than patients with short stature. More specifically, the invention provides: a composition for increasing the body height of an individual comprising a guanyl cyclase B (GC-B) activator as an active ingredient, the composition being to be administered to an individual free from FGFR3 abnormality; a method for increasing the body height of an individual free from FGFR3 abnormality which comprises activating GC-B; a method for screening an agent for increasing the body height of an individual which comprises selecting an agent for increasing the body height using GC-B activity as an indication; and a method for extending a cartilage bone free from FGFR3 abnormality which comprises activating GC-B in an individual.

발명자: Kazuwa Nakao, Akihiro Yasoda, Hidetomo Kitamura
현행 미국 분류: 514/1.1; 435/29; 530/300; 530/324; 530/326

Guanyl cyclase (GC) is a membrane protein belonging to the enzyme family that catalyzes the synthesis of the second messenger cGMP from GTP, and its examples include GC-A, GC-B, . . . , and GC-F. GC-B is found mainly in vascular endothelial cells, and thought to be involved in relaxation of the smooth muscle.

An object of the present invention is to provide a composition for increasing a body height of a patient with short stature or an individual other than patients with short stature, who is free from FGFR3 abnormality, for therapeutic, cosmetic, or other purposes.

It is another object of the present invention to provide a method for increasing a body height in a patient with short stature or an individual other than patients with short stature by the activation of GC-B, wherein said patient and individual are both free from FGFR3 abnormality.

A further object of the present invention is to provide a method for screening for an agent for increasing a body height using the activity of GC-B as an indication.

A still further object of the present invention is to provide a method for extending a cartilage bone free from FGFR3 abnormality by the activation of GC-B.

Me: What is even more intriguing for me was that when I typed in the phrase “Epiphyseal plate regeneration” into google, the article below appeared on the first page. This shows that a MD was looking at the possibility of using CNP to help treat the most common form of dwarfism, achondrodysplasia. What is noted is that shortened growth plates appeared to have been regenerated, but the rate at which chondrocytes slow down on their proliferation was not decreased. 
From my readings, this is how the first 4 types of FGF regulate longitudinal bone growth, which comes from multiple resources.
FGF-1 : negatively 
FGF-2: positively
FGF-3: negatively
FGF-4: positively 
Source Link HERE . Read the highlighted parts!
C-type Natiuretic Peptide and Achondroplasia
Volume 20, Issue 2, 2004
© 2004 Prime Health Consultants, Inc.
C-type natiuretic peptide (CNP) is a member of a family of 3 related peptides—atrial natiuretic peptide (ANP), brain natiuretic peptide (BNP), and CNP. They act by inducing accumulation of intracellular cGMP through 2 subtypes of guanylyl cyclase: guanylyl cyclase A for ANP and BN,P and guanylyl cyclase B for CNP. Although the natiuretic peptides are known mainly for regulating the cardiovascular system, there is growing evidence that CNP is an important positive regulator of endochondral bone growth. For example, genetically engineered mice have short bones when null for CNP and long bones when CNP is overexpressed. In fact, growth plates in these mice are shortened and widened in a manner similar to that detected in mice with loss- and gain-of-function mutations for FGFR3, respectively. These observations led the group headed by Nakao to propose a functional relationship between CNP and FGF signaling in the growth plate, which they have now demonstrated by mouse genetics.The group first generated transgenic mice in which CNP was overexpressed in the growth plate; expression of the gene encoding CNP, designated Nppc, was driven by the type II collagen cartilage-specific promoter (Col2). The Col2-Nppctransgenic mice displayed excessive skeletal growth that was mainly postnatal. Compared to non-transgenic littermates, the Col2-Nppc transgenic mice had longer body length, longer limb bones, a longer cranial base (measured as naso-occipital distance), and wider growth plates by histology.Next, the Col2-Nppc transgenic mice were mated to another transgenic mouse strain in which the achondroplasia-activating mutation of FGFR3 was expressed in cartilage also under the control of the type II collagen promoter (Col2-FGFR3 ach). The latter mouse strain exhibits a dwarf phenotypic with characteristics of human achondroplasia and is considered an animal model for this condition. Offspring of this mating that carried both the Col2-Nppc and Col2-FGFR3 ach transgenes had near normal body lengths when measured over 10 weeks. At 3 months, measurements of cranial base length, femurs, and humeri were statistically the same as non-transgenic mice, indicating that over-expression of CNP in the growth plate had rescued the dwarfism caused by the achondroplasia transgene. There was also restoration of the shortened growth plate of the Col2-FGFR3 ach mice toward normal in the mice harboring both transgenes. Of note, the over-expression of CNP did not appear to rescue the reduced proliferation of growth plate chondrocytes detected in the Col2-FGFR3 ach mice.To confirm the direct effect of CNP on bone growth, the authors treated cultured tibias from Col2-FGFR3 ach mice with different doses of CNP. Bone length showed a dose response to the CNP. The dose that restored bone length to normal also restored synthesis of 2 markers of cartilage matrix biosynthesis—glycosaminoglycan and collagen—which were reduced in the Col2-FGFR3 achmice to near normal.

The authors next examined the effect of CNP on FGFR3 signaling pathways in the tibial explants. No differences were observed in FGF–induced STAT1 signaling, which has been implicated in the control of chondrocyte proliferation. However, CNP reduced signaling through the MAP kinase-ERK pathway.

The model that Yasoda et al 1 constructed suggests that FGFR3 signals through STAT1 to down regulate chondrocyte proliferation and differentiation and through the MAP kinase-ERK pathway to negatively control matrix synthesis in the growth plate. They propose that CNP blocks the MAP kinase inhibitory signals of FGFR3 to increase matrix synthesis and thereby counters the restraining consequences of FGFR3 on bone growth. They speculate that these observations could form a basis for a new therapeutic approach to treating achondroplasia.

Yasoda A, Komatsu Y, Chusho H, et al. Overexpression of CNP in chondrocytes rescues achondroplasia through MAPK-dependent pathway. Nat Med. 2004;10:80-86.

Editor’s Comment : This is a very interesting paper that brings to the fore a growth plate regulatory circuit that has not been widely appreciated in the bone growth field. It also suggests that contrary to the popular view that activating FGFR3 mutations acts primarily through inhibition of chondrocyte proliferation and differentiation, they may also act by inhibiting the synthesis of the extracellular matrix that also contributes to bone growth.

The idea that CNP could be used to stimulate growth in achondroplasia is intriguing. Obviously, this work needs to be confirmed and much more investigation done, but in theory, blocking a downstream pathway that propagates growth inhibitory FGFR3 signals has promise.

Of caution is that high levels of CNP likely generated in cartilage of the transgenic mice, which presumably would be needed to counter the effects of mutant FGFR3 in patients, may be very difficult to achieve in a therapeutic setting, especially without having adverse effects on other tissues that respond to CNP such as kidney, adrenal gland, and cardiovascular system or on other regulatory circuits that utilize MAP kinase-ERK pathways. Nevertheless, the unfolding of this story deserves considerable attention.

William A. Horton, MD