Taller People Are More Likely To Develop Cancer

About a year ago (2011) there was a study that was published and spread by the international news groups about the link between the increased height of the general world population and the increase in cancer rates in the world.

I remember once a person on a website saying that technically, cancer is just any type of cell division growth that becomes uncontrollable. The cells can not stop differentiating and multiplying and move from a benign tumor to a malignant tumor. Thus, taller people usually have more mass than shorter people. So they have more cells. That would correlate in a linear way to the fact that with more mass and more cells, there is a higher chance that one of the cells in the taller person’s body will turn malignant and start multiplying without stop.

Of course there are some factors which can increase the possibility go cell mutation into uncontrollable growth, like radiation, electricity, certain chemicals, and even virus. There are also factors which decrease the possibility of cancer like exercise, resveratrol, good food, etc. However, what the guy was making the point was that on average, taller people should have a higher rate of possible cancer, if all other factors are held constant.

I will only post on here the story told by The Telegraph, a news site from the UK (link at the bottom) and the Huffington Post (source HERE). If you wanted to read more about the studies and the news articles published talking about it, refer to the links I have put up at the bottom of the article. As always, the most important parts will be highlighted. Thank you.


Tall people at greater cancer risk

Taller people are more likely to get cancer, a study shows.

7:00AM BST 21 Jul 2011
The likelihood of developing the disease rises 16 per cent for every extra four inches in height among women – and a similar pattern is also seen in men.

Although previous research has linked height with particular tumours – such as breast in women and testicular in men – new findings show the phenomenon is not restricted to any types of the disease.

Dr Jane Green, who led the research, said: “The fact that the link between height and cancer risk seems to be common to many different types of cancer in different people suggests there may be a basic common mechanism, perhaps acting early in peoples’ lives, when they are growing.

“Of course people cannot change their height. And being taller has actually been linked to a lower risk of other conditions, such as heart disease.

Hormone levels related to childhood growth, and in turn to cancer risk in later life, could be behind the phenomenon.

It was also suggested the link could simply be down to the fact that taller people have more cells in their bodies, and so a greater chance of developing cancerous cell changes.

Dr Green said: “One possible reason is fairly obvious – tall people have more cells so there is a greater chance that one of them could mutate.

“But being tall is also related to hormonal growth factors which leads to a higher turnover of cells and this is an interesting possibility.

“There is nothing we can do about our height but these findings may open the door to discovering how some cancers may develop.”

She went on: “Although we carried out our study in women when we compared the results to previous ones involving both sexes we found a similar link between cancer and height in men.

So there is no gender bias and the association seems to apply to a range of cancers – it’s just most studies have been carried out on the more common ones like breast and colorectal.”

Dr Green and colleagues, whose findings are published online in The Lancet Oncology, said previous studies have shown a link between height and cancer risk but their’s extends the findings to more cancers and for women with differing lifestyles and economic backgrounds.

The results also suggest increases in the height of populations over the course of the 20th century might explain some of the changes in cancer incidence over time.

The height of European adults increased by about 1cm (0.39 inches) per decade during the twentieth century, and the study suggests that this may explain around 10-15 per cent of the rise in cancer cases seen over this period.

The researchers assessed the association between height and cancer among 97,000 cases identified from the Million Women Study which included 1.3 million middle-aged women in the UK enrolled between 1996 and 2001.

During an average follow-up time of about ten years the largest study of its kind found the risk rose in tandem with height and included at least ten types of the disease including breast, skin, bowel, leukaemia and ovarian – a wider range than initially thought.

The researchers who looked at women with heights ranging from under 155cm (5ft 1in) to 175cm (5ft 9in) and taller then compared their results with those from ten previous studies involving both men and women and found they were strikingly similar.

Dr Green said: “We showed the link between greater height and increased total cancer risk is similar across many different populations from Asia, Australasia, Europe, and North America.”

Dr Andrew Renehan, of Manchester University, who reviewed the study for the journal, said: “In the future, researchers need to explore the predictive capacities of direct measures of nutrition, psychosocial stress and illness during childhood, rather than final adult height.”

Sara Hiom, director of health information at Cancer Research UK, said: “Tall people need not be alarmed by these results.

Most people are not a lot taller (or shorter) than average, and their height will only have a small effect on their individual cancer risk.

“This study confirms the link between height and cancer paving the way for studies to help us understand why this is so.

“On average, people in the UK have a more than one in three chance of developing cancer in their lifetime. So it’s important that everyone is aware of what is normal for their body and go see their doctor as quickly as possible if they notice any unusual changes.

“And while we can’t control our height, there are many lifestyle choices people can make that we know have a greater impact on reducing the risk of cancer such as not smoking, moderating alcohol, keeping a healthy weight and being physically active.”


Tall Women May Have A Greater Cancer Risk

Huffington Post   Amanda Chan First Posted: 07/21/11 02:28 PM ET Updated: 09/20/11 06:12 AM ET

Tall women may be more likely to develop several different cancers than their shorter counterparts, a new study suggests.

Published in the journal Lancet Oncology, the study shows that for every 4-inch increase in height, the risk of 10 different cancers — include leukemia, melanoma, breast, ovarian, bowel and uterine cancer — goes up 16 percent.

“Because height is linked to a wide range of cancersin a wide range of people, [the finding] may give us a clue to basic common mechanisms for cancer,” study researcher Jane Green, a cancer epidemiologist at the University of Oxford, told ABC News.

So what should you do if you’re tall? First, don’t panic. The study found an association, not direct link. And of course, height is something that is largely out of our control — affected by genetics and nutrition.

The results also don’t suggest that tall people need extra cancer screening.

Luckily, it’s not all bad news for tall people — a study published this month in the Journal of Epidemiology and Community Health shows that longer legs seems to be tied with a longer lifespan, the Daily Mailreported.

This isn’t the first study to link physical attributes to cancer risk. Research published last year in the British Journal of Cancer showed that men who have long index fingers have a decreased risk of prostate cancer, because finger length seems to be linked with the amount of testosterone a man produces.

In the new study, the researchers analyzed the health information and height of more than 1 million women who participated in the Million Women Study between 1996 and 2001, none of whom had been diagnosed with cancer at the start of the study. They followed the women for nine years.

The researchers grouped the women into groups by height, with the shortest group consisting of women who are less than 5 feet 1 inch in height, and the tallest group consisting of women who are 5 feet 9 inches or taller.

Even though the researchers found that the taller women seemed to have fewer children and drink more alcohol than the shorter women, they were less likely to be smokers or obese and were more likely to be wealthy and active, the study said. Despite this, the taller women seemed to be more likely to develop cancer.

For every 4 inches of height, cancer risk increased by 32 percent for skin cancer, 29 percent for kidney cancer, 26 percent for leukemia and 16 percent for breast cancer.

The Telegraph UKScienceShotThe Guardian UKTime Healthland – BBC News

The Connection Between Height And Fibroblast Growth Factor FGF

[Note: This is the 3rd guest post by the coworker who has been contributing in writing posts for the website. The previous they wrote about was on statin HERE and bone morphogenic proteins BMPs HERE,  Thanks Nicki.]

FGFs

Fibroblast growth factors (FGFs) and their receptors (FGFRs) negatively regulate longitudinal bone growth. Activating FGFR3 mutations impair growth, causing human skeletal dysplasias, whereas inactivating mutations stimulate growth. Systemic administration of FGF-2 to mice stimulates bone growth at low doses but inhibits growth at high doses. In organ culture, FGF-2 inhibits growth by decreasing growth plate chondrocyte proliferation, hypertrophy and cartilage matrix synthesis. Local FGF-2 infusion accelerates ossification of growth plate cartilage. Thus, FGFs may regulate both growth plate chondrogenesis and ossification.

Fibroblast growth factor (FGF) signaling is essential for endochondral bone formation. Most previous work in this area has focused on embryonic chondrogenesis. To explore the role of FGF signaling in the postnatal growth plate, we quantitated expression of FGFs and FGF receptors (FGFRs) and examined both their spatial and temporal regulation.

Toward this aim, rat proximal tibial growth plates and surrounding tissues were microdissected, and specific mRNAs were quantitated by real-time RT-PCR. To assess the FGF system without bias, we first screened for expression of all known FGFs and major FGFR isoforms. Perichondrium expressed FGFs 1, 2, 6, 7, 9, and 18 and, at lower levels, FGFs 21 and 22. Growth plate expressed FGFs 2, 7, 18, and 22. Perichondrial expression was generally greater than growth plate expression, supporting the concept that perichondrial FGFs regulate growth plate chondrogenesis. Nevertheless, FGFs synthesized by growth plate chondrocytes may be physiologically important because of their proximity to target receptors. In growth plate, we found expression of FGFRs 1, 2, and 3, primarily, but not exclusively, the c isoforms. FGFRs 1 and 3, thought to negatively regulate chondrogenesis, were expressed at greater levels and at later stages of chondrocyte differentiation, with FGFR1 upregulated in the hypertrophic zone and FGFR3 upregulated in both proliferative and hypertrophic zones. In contrast, FGFRs 2 and 4, putative positive regulators, were expressed at earlier stages of differentiation, with FGFR2 upregulated in the resting zone and FGFR4 in the resting and proliferative zones. FGFRL1, a presumed decoy receptor, was expressed in the resting zone.

With increasing age and decreasing growth velocity, FGFR2 and 4 expression was downregulated in proliferative zone. Perichondrial FGF1, FGF7, FGF18, and FGF22 were upregulated.

In summary, we have analyzed the expression of all known FGFs and FGFRs in the postnatal growth plate using a method that is quantitative and highly sensitive. This approach identified ligands and receptors not previously known to be expressed in growth plate and revealed a complex pattern of spatial regulation of FGFs and FGFRs in the different zones of the growth plate. We also found temporal changes in FGF and FGFR expression which may contribute to growth plate senescence and thus help determine the size of the adult skeleton.

The family of FGFs constitutes at least 22 members that interact with at least four receptors (FGFR) and are major regulators of embryonic bone development.Both FGF1 and -2 as well as FGFR1, -2, and -3 are expressed in chondrocytes.In humans, activating mutations in the FGFR3 cause achondroplasia,the most common type of human dwarfism (97% of mutations have a Gly to Arg mutation in codon 380).Other forms of chondrodysplasia due to mutations in the FGFR3 gene include hypochondroplasia, a milder form of dwarfism and two severe types, SADDAN (severe achondroplasia with developmental delay and acanthosis nigricans), and thanatophoric dysplasia.Conversely, mice with an inactivating mutation in the FGFR3 gene demonstrate increased longitudinal growth. In addition, overexpression of FGF2 slows longitudinal growth.Only very recently, mice lacking FGF18 have been generated. These mice demonstrated a phenotype similar to that observed in mice lacking FGFR3, including expanded proliferating and hypertrophic zones, increased proliferation, differentiation, and Ihh signaling.In addition, FGF18 deficiency leads to delayed ossification and decreased expression of osteogenic markers, not seen in the FGFR3 knockout phenotype, which prompted the authors to suggest that FGF18 coordinates chondrogenesis and osteogenesis through FGFR3 and -2, respectively. In addition, FGF18 appeared to act as a physiological ligand for FGFR3 in the growth plate. These studies indicate that FGFR signaling reduces growth by inhibiting proliferation and differentiation.

Mancilla et al.  studied the effects of FGF2 on chondrocyte differentiation in a metatarsal organ culture system and found three growth-inhibiting mechanisms for FGF2: decreased growth plate chondrocyte proliferation, decreased cellular hypertrophy, and at high concentrations, decreased synthesis of cartilage matrix. Recently, a mouse model for thanatophoric dysplasia characterized by severe dwarfism was used to study the relationship between FGF signaling and the Ihh/PTHrP feedback loop. In these newborn mice with an activated FGFR3, Ihh and PTHrP mRNA expression were both down-regulated. In the same study, embryonic metatarsals from wild-type mice were cultured in the presence of FGF2, and similar results were found. Interestingly, FGF inhibited chondrocyte proliferation by down-regulating Ihh expression. Moreover, FGF and PTHrP signals independently inhibited chondrocyte differentiation. It was concluded that FGFR3 and PTHrP/Ihh signals act through two integrated parallel pathways that mediate both overlapping and distinct functions during longitudinal bone growth. In a recent study by Minina et al. , using a limb culture system, it was found that FGF and BMP signaling are antagonistic in the regulation of chondrocyte proliferation and in Ihh expression and the process of hypertrophic differentiation. The balance between the two adjusts the pace of the differentiation process to the proliferation rate.

Abstract

In vivo, fibroblast growth factor-2 (FGF-2) inhibits longitudinal bone growth. Similarly, activating FGF receptor 3 mutations impair growth in achondroplasia and thanatophoric dysplasia. To investigate the underlying mechanisms, we chose a fetal rat metatarsal organ culture system that would maintain growth plate histological architecture. Addition of FGF-2 to the serum-free medium inhibited longitudinal growth. We next assessed each major component of longitudinal growth: proliferation, cellular hypertrophy, and cartilage matrix synthesis. Surprisingly, FGF-2 stimulated proliferation, as assessed by [3H]thymidine incorporation. However, autoradiographic studies demonstrated that this increased proliferation occurred only in the perichondrium, whereas decreased labeling was seen in the proliferative and epiphyseal chondrocytes. FGF-2 also caused a marked decrease in the number of hypertrophic chondrocytes. To assess cartilage matrix synthesis, we measured 35SO4 incorporation into newly synthesized glycosaminoglycans. Low concentrations (10 ng/ml) of FGF-2 stimulated cartilage matrix production, but high concentrations (1000 ng/ml) inhibited matrix production. We conclude that FGF-2 inhibits longitudinal bone growth by three mechanisms: decreased growth plate chondrocyte proliferation, decreased cellular hypertrophy, and, at high concentrations, decreased cartilage matrix production. These effects may explain the impaired growth seen in patients with achondroplasia and related skeletal dysplasias.

Abstract

FGF21

Fibroblast Growth Factor 21 (FGF21) modulates glucose and lipid metabolism during fasting. In addition, previous evidence indicates that increased expression of FGF21 during chronic food restriction is associated with reduced bone growth and Growth Hormone (GH) insensitivity. In light of the inhibitory effects on growth plate chondrogenesis mediated by other FGFs, we hypothesized that FGF21 causes growth inhibition by acting directly at the long bones′ growth plate. We first demonstrated the expression of FGF21, FGFR1 and FGFR3 (two receptors known to be activated by FGF21), and β-klotho (a co-receptor required for the FGF21-mediated receptor binding and activation) in fetal and 3-week old mouse growth plate chondrocytes. We then cultured mouse growth plate chondrocytes in the presence of graded concentrations of rhFGF21 (0.01-10 μg/ml). Higher concentrations of FGF21 (5 and 10 μg/ml) inhibited chondrocyte thymidine incorporation and collagen X mRNA expression. 10 ng/ml GH stimulated chondrocyte thymidine incorporation and collagen X mRNA expression, with both effects being prevented by the addition in the culture medium of FGF21 in a concentration-dependent manner. In addition, FGF21 reduced GH binding in cultured chondrocytes. In cells transfected with FGFR1 siRNA or ERK 1 siRNA, the antagonistic effects of FGF21 on GH action were all prevented, supporting a specific effect of this growth factor in chondrocytes. Our findings suggest that increased expression of FGF21 during food restriction causes growth attenuation by antagonizing the GH stimulatory effects on chondrogenesis directly at the growth plate. In addition, high concentrations of FGF21 may directly suppress growth plate chondrocyte proliferation and differentiation.

Abstract

Endochondral ossification is a major mode of bone formation that occurs as chondrocytes undergo proliferation, hypertrophy, cell death, and osteoblastic replacement. We have identified a role for fibroblast growth factor receptor 3 (FGFR-3) in this process by disrupting the murine Fgfr-3 gene to produce severe and progressive bone dysplasia with enhanced and prolonged endochondral bone growth. This growth is accompanied by expansion of proliferating and hypertrophic chondrocytes within the cartilaginous growth plate. Thus, FGFR-3 appears to regulate endochondral ossification by an essentially negative mechanism, limiting rather than promoting osteogenesis. In light of these mouse results, certain human disorders, such as achondroplasia, can be interpreted as gain-of-function mutations that activate the fundamentally negative growth control exerted by the FGFR-3 kinase.

Conclusion: It appears that the Fibroblast Growth Factors, The FGF 1,2,3,4 all regulate the endochondral ossification process. There are a few studies that showed low rates of the FGF seems to increase longitudinal growth of the growth plates on the perineum outer layer but at high levels, all of the FGFs seems to inhibit the bone lengthening and slow down the growth process. As stated above

“”We conclude that FGF-2 inhibits longitudinal bone growth by three mechanisms: decreased growth plate chondrocyte proliferation, decreased cellular hypertrophy, and, at high concentrations, decreased cartilage matrix production””

The mechanism that is guessed to inhibit it is by down-regulating Ihh expression. The FGF21 does the same thing.

Increase Height And Grow Taller Using Nitric Oxide

Another compound that I have seen a lot of talk on the Impartial Height Increase Boards was the talk of either trying to increase the release of Nitric Oxide into the system. Here is what I found on the compound.

From source link HERE

Me: It turns out Nitric Oxide is derived from the amino acid Arginine. The production of Nitric Oxide occurs when the amino acid L-arginine is converted into L-citruline through an enzyme group known as Nitric Oxide Synthase (NOS). Apparently you can increase the release of NO in the system by either exercising, takin orally amino acid supplements, and such. Interestingly, in my searching it seems HeightQuest also wrote a post suggesting that NO might possibly be used to increase height located HERE. Tyler states that NO seems to be able to only lengthen the flat, irregular, and short bones but not the long bones since NO seems to only affects to osteoblasts (at least claimed by him). I would that since the effect of NO is basically to relax the body and make blood vessels increase in diameter, leading to better cell communication, it can only help in any type of cellular mechanisms.

From the website Nutrition Express

What is nitric oxide and how does it work?

by Jason Clark, BSc, MSc
What Is nitric oxide and how does it work?
Some people think it’s the gas that makes us laugh at the dentist office. Some think it’s the fuel racecar drivers use to speed up their cars. But it’s neither. Nitric oxide is a molecule that our body produces to help its 50 trillion cells communicate with each other by transmitting signals throughout the entire body.

Nitric oxide has been shown to be important in the following cellular activities:

• help memory and behavior by transmitting information between nerve cells in the brain
• assist the immune system at fighting off bacteria and defending against tumors
• regulate blood pressure by dilating arteries
• reduce inflammation
• improve sleep quality
• increase your recognition of sense (i.e. smell)
• increase endurance and strength
• assist in gastric motilityThere have been over 60,000 studies done on nitric oxide in the last 20 years and in 1998, The Nobel Prize for Medicine was given to three scientists that discovered the signaling role of nitric oxide.

Nitric oxide and heart disease 
Nitric oxide has gotten the most attention due to its cardiovascular benefits. Alfred Nobel, the founder of the Nobel Prize, was prescribed nitroglycerin over 100 years ago by his doctor to help with his heart problems. He was skeptical, knowing nitroglycerin was used in dynamite, but this chemical helped with his heart condition. Little did he know nitroglycerin acts by releasing nitric oxide which relaxes narrowed blood vessels, increasing oxygen and blood flow.

The interior surface (endothelium) of your arteries produce nitric oxide. When plaque builds up in your arteries, called atherosclerosis, you reduce your capacity to produce nitric oxide, which is why physicians prescribe nitroglycerin for heart and stroke patients.

Nitric oxide and erectile dysfunction 

Viagra and other impotence medications work due to their action on nitric oxide. One cause of impotence is unhealthy and aged arteries that feed blood to the sexual organs. Viagra works by creating more nitric oxide, causing a cascade of enzymatic reactions magnifying and extending nitric oxide, causing more blood flow and better erections.

How to increase nitric oxide in your body 

The most common way to increase nitric oxide is through exercise. When you run or lift weights, your muscles need more oxygen which is supplied by the blood. As the heart pumps with more pressure to supply the muscles with blood, the lining in your arteries releases nitric oxide into the blood, which relaxes and widens the vessel wall, allowing for more blood to pass though. As we age, our blood vessels and nitric oxide system become less efficient due to free radical damage, inactivity, and poor diet, causing our veins and arteries to deteriorate. Think of a fire hose as water rushes through it to put out a fire – it needs to expand enough to handle the pressure, still keeping enough force to put out the fire. Athletes and youth have the most optimal nitric oxide systems, reflecting their energy and resilience.

Diagram 1Another way to increase nitric oxide is through diet, most notably by consuming the amino acids L-arginine and L-citrulline. Arginine, which can be found in nuts, fruits, meats and dairy, directly creates nitric oxide and citrulline inside the cell (diagram 1).(6) Citrulline is then recycled back into arginine, making even more nitric oxide. Enzymes that convert arginine to citrulline, and citrulline to arginine need to function optimally for efficient nitric oxide production. We can protect those enzymes and nitric oxide by consuming healthy foods and antioxidants, like fruit, garlic, soy, vitamins C and E, Co-Q10, and alpha lipoic acid, allowing you to produce more nitric oxide. Nitric oxide only lasts a few seconds in the body, so the more antioxidant protection we provide, the more stable it will be and the longer it will last. Doctors are utilizing this science by coating stents (mesh tubes that prop open arteries after surgery) with drugs that produce nitric oxide.

Nitric oxide for athletes and bodybuilders 
Increasing nitric oxide has become the new secret weapon for athletes and bodybuilders. Athletes are now taking supplements with L-arginine and L-citrulline to increase the flow of blood and oxygen to the skeletal muscle which can augment strength and endurance. They also use them to facilitate the removal of exercise-induced lactic acid build-up which reduces fatigue and recovery time. Since arginine levels become depleted during exercise, the entire arginine-nitric oxide – citrulline loop can lose efficiency, causing less-than-ideal nitric oxide levels and higher lactate levels. Supplements can help restore this loop allowing for better workouts and faster recovery from workouts.With nitric oxide deficiencies due to aging, inactivity, smoking, high cholesterol, fatty diets, and lack of healthy foods, increasing your nitric oxide levels can help increase your energy, vitality and overall wellness. The basic adage of eating well and staying active all makes sense now.

WARNING: If you have an existing heart condition or abnormal blood pressure, please consult your healthcare professional before taking supplements to increase nitric oxide levels.

The Bone Growth Pill From Zymogenetics

More than a decade ago the biotech company Zymogenetics located in Seattle had apparently found 3 types of compounds (2 synthetic, and 1 natural) which had shown that they can stimulate osteoblasts, such as parathyroid hormone and bone morphogenic proteins (BMPs). After some research, I discovered the natural compound was statin, the compound most commonly known for being in the Lipitor drug used to lower cholesterol. My coworker had actually written her first post on the possibility of using Statin to possibly increase height and grow taller.

If you really wanted to know what the other two synthetic compounds are, then click on the links below which are old patents that have passed their time limit

Patent Link 1 (# 7951380) – Title: “Methods of stimulating bone growth using ZVEGF4 polypeptides” –

Patent Link 2(# AU1998057981) – Title: “COMPOSITIONS AND METHODS FOR STIMULATING BONE GROWTH

The drugs that they were testing never got any more news about what happened to them. From working in the past in the pharmaceutical industry, I would guess there was not enough funding or interest in getting the drugs out to market. It was indeed an absolute breakthrough for the medical community and especially for people suffering from osteoporosis.

The thing to note that the drug was never intended to be used to extend the actual form in our bodies, but to increase the body density in our bones. So technically, the drugs indeed did promote bone growth, but did not grow bones in the way us height increasers had been hoping for.

The article I will be posting below is from the Science Daily website HERE. Note that it was written in 1999, such a long time ago. Another article written by the BBC is located HERE.


New Chemicals Could Lead To First Bone Growth Pill

ScienceDaily (Mar. 22, 1999) — ANAHEIM, Calif., March 21 — New chemicals that, if successful, could become the first osteoporosis treatment to stimulate new bone growth — rather than merely retard bone loss — were described here today at a national meeting of the American Chemical Society, the world’s largest scientific society. Researchers from the Seattle biotechnology company ZymoGenetics Incorporated said their new compounds are showing positive results in animals and, unlike other bone-growth candidates, can be put in a pill.

In humans, bone undergoes continuous remodeling, with cells called osteoclasts “eating up”old bone as osteoblast cells replace it with new bone. Osteoporosis, which affects some 15-20 million Americans, is caused by increased bone breakdown without new bone formation. The result is a loss of bone mass and increased susceptibility to fractures, most commonly in those age 45 and older. The cost of treatments associated with osteoporosis in the U.S. has been estimated at $3.8 billion annually.

Current treatments, including estrogens, all act to decrease bone loss. They can’t do anything about bone that is already gone and, therefore, are not helpful to everyone. “Our new bone forming agents may have better and more widespread utility for treatment of osteoporosis,” said ZymoGenetics senior scientist Nand Baindur, Ph.D.

There are currently no drugs available to help grow bone. Researchers have tried giving patients proteins that the body naturally uses to stimulate osteoblasts, such as parathyroid hormone and bone morphogenic proteins (BMPs). But, according to Dr. Baindur, those clinical trials have been mostly unsuccessful or inconclusive. Furthermore, he explains that proteins are big molecules which can usually be given only by injection and don’t hold up well in the body. Even if such treatments worked, he adds, the proteins are generally difficult to formulate and manufacture, tending to eventually make them expensive.

Instead of using the proteins themselves, Dr. Baindur’s laboratory screened tens of thousands of compounds for the ability to stimulate BMPs. They have selected three — two synthetic chemicals and one natural product — for pre-clinical development, and early indications look promising. “This is the first report of small molecule drug-like compounds which have been shown to stimulate the formation of new bone in animals,” says Dr. Baindur.

Such small molecule compounds are not only relatively inexpensive and easily made, but usually quite stable. Dr. Baindur adds that they can also be easily modified or formulated as the need arises. The new compounds should be able to be put into pill form. While no human tests have yet been conducted, Dr. Baindur says “these compounds are predicted to be useful in the clinical treatment of osteoporosis and related bone-deficit conditions, including bone fractures. As bone formation agents, they can potentially be given alone or in combination with agents which decrease bone loss.”

While bone regenerating pills are probably years away from the market, there is the possibility that one of the new compounds might have a head start in clinical trials. The natural product candidate is part of a chemical class called statins, some of which are already in use for the treatment of heart disease.

 

A Study On Diastrophic Dysplasia

This post is added for information reasons so the reader and I will be more aware of the types of dwarfism conditions. Diatrophic dysplasia is one of those types of dwarfism that usually results in severe types of dwarfism because the limbs are also affected and become stunted.

From the National Institute of Health government website HERE

What is diastrophic dysplasia?

Diastrophic dysplasia is a disorder of cartilage and bone development. Affected individuals have short stature with very short arms and legs. Most also have early-onset joint pain (osteoarthritis) and joint deformities called contractures, which restrict movement. These joint problems often make it difficult to walk and tend to worsen with age. Additional features of diastrophic dysplasia include an inward- and upward-turning foot (clubfoot), progressive abnormal curvature of the spine, and unusually positioned thumbs (hitchhiker thumbs). About half of infants with diastrophic dysplasia are born with an opening in the roof of the mouth (a cleft palate). Swelling of the external ears is also common in newborns and can lead to thickened, deformed ears.

The signs and symptoms of diastrophic dysplasia are similar to those of another skeletal disorder called atelosteogenesis type 2; however, diastrophic dysplasia tends to be less severe. Although some affected infants have breathing problems, most people with diastrophic dysplasia live into adulthood.

Read more about atelosteogenesis type 2.

How common is diastrophic dysplasia?

Although the exact incidence of this condition is unknown, researchers estimate that it affects about 1 in 100,000 newborns. Diastrophic dysplasia occurs in all populations but appears to be particularly common in Finland.

What genes are related to diastrophic dysplasia?

Diastrophic dysplasia is one of several skeletal disorders caused by mutations in the SLC26A2 gene. This gene provides instructions for making a protein that is essential for the normal development of cartilage and for its conversion to bone. Cartilage is a tough, flexible tissue that makes up much of the skeleton during early development. Most cartilage is later converted to bone, except for the cartilage that continues to cover and protect the ends of bones and is present in the nose and external ears. Mutations in the SLC26A2 gene alter the structure of developing cartilage, preventing bones from forming properly and resulting in the skeletal problems characteristic of diastrophic dysplasia.

Read more about the SLC26A2 gene.

How do people inherit diastrophic dysplasia?

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

The Story Of Caitlin Schroeder And Her Limb Lengthening Surgery

When I was going through a few papers two days ago, I stumbled upon the story of Caitlin Shroeder, who suffered from hypochondroplasia, a type of dwarfism. Caitlin had decided to go through with lim lengthening surgery to increase by 5.75 inches going from 4′ 2.75″ to to 4′ 8.5″.

I thought the story was very touching and I wanted to post the written story here for any readers who might be interested in reading about her story and the things she had to go through.

Caitlin’s story of physical transformation was even featured on NPR (National Public Radio) and her mother was interviewed (source HERE). if you want to read the transcript or listen to the interview just click on the link above.

The story was written up but the Washington Post (source HERE) author Caitlin Gibson.


Growing Pains: A Teen, Born With Dwarfism, Undergoes the Grueling Process of Limb-Lengthening

Sunday, November 30, 2008By Caitlin Gibson

Behind the house, in the sprawling back yard filled with picnic tables and trees, guests are gathering for the Fourth of July party. You can’t miss Caitlin Schroeder in the crowd: She’s the pretty teenager in a wheelchair festively draped with multicolored feather boas and strands of beads, the girl with honey blond hair tucked behind her ears and a shy, genuine smile. She’s wearing a T-shirt and shorts, her bare legs covered by a sheet. Hidden beneath the folds are 24 metal pins protruding from her flesh, each with one end anchored in bone and the other secured by a boxy, external plastic frame along her calves and thighs.

It’s a clear midsummer night in 2007, and this is the first social gathering that Caitlin and her family have attended in more than three months, since the surgery that broke both of Caitlin’s legs and drilled the pins into her bones in late March. The fabric draped over her is uncomfortably warm, but Caitlin’s not ready for people to see her legs. She doesn’t like being the center of attention, though her patience with human nature is uncommon for a 13-year-old: I don’t like being stared at, she often says, but I understand why people look at me.

Caitlin came to her grandparents’ party with her mother, Jennifer Anduha, her stepfather, Mike Anduha, and her little brother, Jackson Anduha. They drove in a van equipped to accommodate Caitlin’s wheelchair from their house in Clinton to the lakeside home of Jennifer’s parents in East Berlin, Pa.

Some of the people here — family and close friends — know Caitlin’s story, the full extent of what she’s going through and why she had the surgery that left her with such startling devices attached to her legs. For those who are meeting her for the first time, the most candid and straightforward explanation comes from 3-year-old Jackson, who says: “Caitlin is getting taller.”

Actually, she has just finished getting taller. Since the day after her surgery, Caitlin, who was born with dwarfism, had been lengthening the bones of her legs. Each day, Caitlin used a wrench to turn screws that pulled the ends of her broken bones apart — one millimeter a day in her upper thighs and 0.75 millimeters in her lower legs — and each day, her bones generated new tissue to cross the distance. Her skin, muscles and blood vessels also stretched and grew as her bones were lengthened. In just three months, the agonizing process added 53/4 inches to Caitlin’s height; she is now 4 feet, 81/2 inches tall. She has recently stopped lengthening, an encouraging turning point, but she has months to go before her bones are mended and the devices are removed.

Most childhood surgeries are dictated by need and decided by others, but this one was different. This was Caitlin’s choice. And, eventually, she’ll have other important decisions to make — about how much more pain, for how many more inches, she is willing to tolerate. Limb-lengthening patients such as Caitlin often undergo multiple procedures, lengthening their legs two or three times and their arms once. This is Caitlin’s first procedure, and she imagines that she might have more surgery; but right now, the thought is overwhelming.

As the sun lowers over the lake, Jackson picks up a red ball and begins a game of catch with Caitlin. The two toss the ball back and forth, chatting and smiling, until Jackson becomes distracted and wanders off, leaving Caitlin alone at the edge of the lawn. She sits quietly by herself, unable to rotate her wheelchair in the soft grass. Behind her, the back yard is filled with lively conversation. A few moments pass before Jennifer realizes that Caitlin is alone, and she rushes over, apologizing for not having noticed sooner. Caitlin apologizes, too, for requiring the extra attention. Then she falls silent as her mother turns the wheelchair and steers her back toward the crowd.

In the beginning of her seventh-grade year, Caitlin decided that she would endure whatever it took to get what she wanted. What she wanted was another five inches of height.

Five inches. For an average-size woman, it’s the difference between being considered somewhat short at 5-foot-4, or somewhat tall at 5-foot-9. Caitlin stopped growing at 4-foot-23/4. For her, five inches means the ability to comfortably walk long distances and climb steps; to safely navigate a stovetop; or to play soccer and keep pace with the other kids on the field. Even seemingly minor details of her daily life would be transformed, “Like being able to see my face in the mirror by the front door,” Caitlin says.

Five more inches, and she could reach the plastic dividers in the checkout lane at the grocery store, or the pedals of a car. Maybe it would even mean that she would feel more comfortable among her peers, that she wouldn’t be left behind when her friends went shopping or ice skating.

But five inches comes at a price. The procedure is called limb-lengthening, and it begins with the breaking of the femur and the tibia — the bones of the upper and lower leg — during a six- to eight-hour surgery. Each bone is carefully chiseled in two, leaving a tiny, jagged gap between the broken halves. Metal pins are screwed directly into the bone and held securely in place by a fixator frame, an external device that provides support as it distracts, or lengthens, the bones. Physical therapy begins the day after the surgery.

———— (pg 2)

Caitlin had her surgery at Sinai Hospital of Baltimore. In the beginning, it was the physical pain that overwhelmed her. Then, as the first few weeks passed, her focus shifted toward the more profound realization of her new limitations: no walking, no running, no movement at all without help. A downstairs living room became her temporary bedroom, and she had to shower at Sinai in a special stall large enough to accommodate a wheelchair. In public, Caitlin wore pants or shorts with snaps on the side to fit over her fixators, which she hated to have to do; she often kept a blanket draped over her legs, but people still stared. At night, she sometimes dreamed of running on a soccer field, and woke in a bed where the devices in her legs forced her to lie still on her back. Visits to her father’s house in Alexandria — Caitlin’s parents divorced when she was 6 years old — were impossible because of the steep steps outside the front door; instead, her father, Stewart Schroeder, went with Caitlin to Sinai every Friday for rehab and visited her in Clinton.

The process was overwhelming and lonely; most of her friends didn’t call or visit as often as she’d hoped they would. But after the 3 months of lengthening ended and Caitlin’s bones began to heal, the results of the procedure were slowly revealed. As her bones strengthened and her physical therapy progressed, she was eventually able to stand and walk short distances.

There came a day, just weeks before the Fourth of July party, when Caitlin walked slowly and awkwardly into the first-floor bathroom of her family’s house. There, Caitlin stood at the sink, and — for the first time in her life — she was tall enough to reach the faucet.

Caitlin’s parents never envisioned their child going through such an excruciating process. As far as Jennifer and Stewart are concerned, their daughter has always been perfect; even as an infant, Caitlin looked more like a china doll than a newborn baby, with white-blond hair and huge blue eyes. But when Caitlin was 11 months old, her parents began to notice that her head seemed disproportionately large and her limbs noticeably short. They brought Caitlin to a pediatrician, who referred them to Kenneth Rosenbaum, a geneticist at Children’s National Medical Center in Washington.

Rosenbaum confirmed that Caitlin had dwarfism, though it was not until Caitlin was 3 years old that a blood test was available to positively identify which type of dwarfism she had. Before her fourth birthday, Caitlin was diagnosed with hypochondroplasia, one of more than 200 types of skeletal dysplasia characterized by disproportionately short legs and arms and heightened risk of certain orthopedic complications — such as arthritis, spinal curvature or compression and dental problems. Though the precise occurrence of hypochondroplasia is uncertain, researchers estimate that it occurs in roughly one in every 15,000 to 40,000 newborns, according to the National Institutes of Health. As in Caitlin’s case, the vast majority of dwarfs are born to parents who do not carry the gene for dwarfism, the result of a spontaneous genetic mutation during pregnancy. There are an estimated 30,000 people with dwarfism in the United States, according to Little People of America, the largest organization for people of short stature in the world.

Rosenbaum recommended that the family meet with Dror Paley, a renowned expert in the field of limb-lengthening. Jennifer and Stewart scheduled an appointment despite Jennifer’s hesitancy. “We felt it was our obligation to check out everything our doctors told us to check out,” Jennifer explains, “but I think, in the beginning, there was no doubt in my mind that we would not do [the lengthening]. I just couldn’t comprehend that it was even going to be an issue.”

By 7 or 8, Caitlin was old enough to have her limbs lengthened — at a younger age, such surgery could stunt normal growth — but Jennifer, who was Caitlin’s primary caregiver after the divorce, was not prepared to make the decision on Caitlin’s behalf. Jennifer clung vehemently to her conviction that Caitlin didn’t need surgery. Even as a young child, Caitlin was a fiercely independent spirit, and Jennifer believed that they should let Caitlin reach a point where she could decide for herself. Stewart — and eventually Mike, who married Jennifer when Caitlin was 9 years old — supported Jennifer and remained informed but otherwise uninvolved in the decision-making process. Paley, meanwhile, didn’t push the surgery; he simply explained that lengthening was most successful when a patient’s bones were young and can heal more readily.

The social implications of Caitlin’s size became rapidly clear after her toddler years. Strangers addressed Caitlin as if she were half her age. The clothes and shoes that fit her were intended for a much younger child. Sometimes Caitlin’s friends excluded her from their play, telling her she was too small.

When Caitlin was 6, Jennifer and Stewart gave her a brand-new, bright-red tricycle for Christmas. She couldn’t reach the pedals.

“That was a rude awakening,” says Jennifer. Though Caitlin was ultimately content with jury-rigged wooden blocks that her grandfather duct-taped to the pedals, Jennifer remembers the moment as the dawning of a new realization.

“It was like, what about when she gets a big bike? What about when she drives a car? It started to become obvious to me what we were in for,” Jennifer recalls. “Even though I was very painfully aware of those things, I was very much against doing the bone-lengthening.”

——– (pg 3)

Jennifer blinks back tears. “She was my child, and I just could not imagine putting her through that.”

Caitlin was a tough, athletic kid who fell in love with soccer in third grade. Her short legs made it difficult to keep up with her peers on the field. By sixth or seventh grade, Caitlin’s size became more of an issue. Jennifer feared for her daughter’s safety. Caitlin’s teammates, Jennifer says, “were like monsters compared to her.” But Caitlin, who was unafraid of the larger kids, was determined to stay on the team. Impressed by her skills and determination, Caitlin’s teammates nicknamed her the “little bulldog.” There were other nicknames, too, ones that stung — even if they were intended to be affectionate, such as “Shorty.”

Caitlin’s feelings about limb-lengthening fluctuated throughout her childhood. Her parents scheduled informational appointments with Paley once every few years so that their daughter could gradually come to understand the surgical option. The technical explanations were left to the surgeons; Jennifer tried to remain neutral despite her own opposition to the procedure. She worried that Caitlin might choose the surgery because of social pressure and a desire to fit in, and stressed to Caitlin that she should focus on her own thoughts and feelings. Caitlin first began to seriously discuss her options with her family around age 10. Her own internal debate was exhausting, and she remembers the relief of finally making her decision.

“I was in school, and I was thinking about how I’d gone back and forth, and how I could probably do that for a long time,” she says. “I was also just thinking, you know, I don’t want to be this short forever.” Caitlin explains that her choice was shaped by years of careful thought and her cumulative childhood experiences as a dwarf. There is, however, one memory in particular that stands out for her.

It was midsummer, six years ago. Caitlin and her cousin Gabby had spent the day walking around the Six Flags St. Louis amusement park, playing games, shopping and avoiding the big roller coasters; Caitlin didn’t like heights, but she also knew that she wouldn’t be allowed to ride them even if she wanted to. She was too small.

Still, Caitlin was compelled by the water slide, despite the long line of people winding up a tall flight of stairs. The stairs were daunting to Caitlin — they looked narrow and rickety, and steps were a strain on her short legs, but the two began a slow, half-hour climb. When they finally got to the top, a man stepped forward to measure their heights. Caitlin felt a wave of anxiety and frustration; why hadn’t they measured at the bottom of the steps? The outcome was exactly what she had expected: Gabby was good to go, but Caitlin was too short. Caitlin told her cousin to go ahead without her. After all, they’d waited in line for a long time. Caitlin turned back, facing the long flight of wooden stairs, crammed with people.

“Excuse me,” she said, pushing through all the way back down. Excuse me. Excuse me. Excuse me.

Caitlin sits on the padded vinyl table, waiting. She fidgets, tugging the hem of her beige T-shirt and running her fingers through her hair. Her legs are spread in front of her, in shorts with snaps on each leg so they can fit over the pins and fixator frames.

The physical therapist should be here any minute now, in this room with the jungle mural painted across multicolored walls and smiling plastic stars dangling from the ceiling. Several large physical therapy tables line the walls, and a television plays a “Strawberry Shortcake” DVD.

Caitlin has spent nearly every weekday morning here at Sinai for the last five months, arriving with her mother by 7:45 a.m. after a 90-minute drive from Clinton. Caitlin’s recovery and therapy schedule is all-consuming; to accommodate it, Caitlin kept up with her schoolwork from home for the remainder of the spring semester, while Jennifer took unpaid family medical leave and recently decided to leave her job as director of operations at a Washington law firm. She’ll look for work again when Caitlin’s procedure is over, she says, “but for now, this is our life.”

This morning, there is a 4-year-old girl in a purple dress on the table beside Caitlin’s, here for her first day of physical therapy after surgery to correct a birth defect. The child’s eyes are riveted on the TV as the therapist lifts her left leg, encircled by a fixator frame and lined with metal pins screwed into her bones. The girl’s father holds her hand as the therapist gently starts to bend the girl’s knee.

———- (pg 4)

The child’s eyes fill with tears, and her chest begins to heave. “Ow, Daddy, ow,” she sobs, her wide eyes still fixed on the television with desperate intensity.

“I know, these are hard,” the therapist says. She bends the girl’s knee further; the child squeezes her eyes shut and screams. The little girl’s father closes his eyes, too, and his shoulders tremble.

If Caitlin’s own pain isn’t enough to handle, there is always the agony of others to witness here, patients in different stages of the same excruciating process. Caitlin vividly recalls the misery of her own first therapy sessions.

“That was really bad,” Caitlin says, wincing at the memory. “They just pushed, and I was terrified to have my knees bent.” The pain often drives patients, children and adults alike, to scream in agony.

Caitlin didn’t make a sound, Jennifer remembers, “but tears just started pouring down her face. And tears were pouring down my face. That was absolutely a low point. That was when I realized what this was really going to be like.”

It’s been six weeks since Caitlin stopped lengthening. Her bones are healing, and she attends physical therapy only twice a week, instead of every day. She is hopeful that her bones have healed well, and she’s only about a month away from the final surgery to remove the devices on her legs. She’ll find out today at a clinic appointment with Paley.

Caitlin’s therapist, Brita Grothe, a petite young woman in black exercise pants, comes in, greets Caitlin warmly and gets started. She rotates Caitlin’s ankles and notes the range of motion. Caitlin clenches her jaw as Grothe lifts her leg to stretch her thigh muscles.

“You’re so tough,” Grothe says, watching her carefully.

When the therapy session is over, Caitlin does her own “pin care,” carefully unwrapping the gauze around each pin site and cleaning the opening with a sterilized cotton swab. Jennifer helps Caitlin shower and dress, and then it’s time to head upstairs for a long afternoon in the clinic waiting room. Paley sees so many patients a day — and he is so frequently called into surgeries he often doesn’t see patients until three to six hours after their appointment time.

They are finally called at 4 p.m. for Caitlin’s 11:30 a.m. appointment. Paley arrives in the examination room 20 minutes later after reviewing X-rays of Caitlin’s legs. A soft-spoken middle-age man with striking blue eyes, Paley gets down to business immediately.

“The bone regeneration looks really good,” Paley says to Jennifer. “She’s solid.”

“Wow,” Jennifer says, visibly relieved. “Really?” Caitlin is grinning.

———— (pg 5, last)

Paley turns his attention to Caitlin and gestures toward her fixators. “You can have those off in September, whenever you can get on my schedule. You’re done,” he says. He adds that Caitlin probably won’t require titanium rods implanted in her femurs, a common precaution taken with many lengthening patients. Her bones appear to be strong enough on their own. Paley reminds them that Caitlin will again revert to a state of complete immobility for one month after the removal of the devices — no physical therapy, no weight-bearing movement whatsoever. This means that Caitlin will rely on her school’s staff for support when she starts eighth grade in a couple of weeks, and Jennifer will need to make a daily trip to school to assist Caitlin in the girls’ bathroom during the day. After that initial period, she will resume physical therapy three times a week.

After a five-hour wait, the appointment is over in five minutes.

But Caitlin doesn’t care about the lost afternoon; she’s elated. What she doesn’t want to dwell on right now is that in less than a year — if she were to follow a typical lengthening schedule — another surgery would affix new devices to her upper arms. The truth is, with the end of her first procedure finally in sight, Caitlin doesn’t know if she can go through it all over again.

***

In the early 1950s, at a small hospital in a remote region of western Siberia, a Russian orthopedist named Gavril Ilizarov developed a groundbreaking surgical technique to treat the badly fractured bones of injured Russian soldiers. The Ilizarov method of limb reconstruction is based on the idea that new bone growth can be stimulated by “distraction,” or pulling the ends of a broken bone apart, while stabilizing the limbs with an external frame. It is only within the last 20 years, however, that limb-lengthening has become available to symmetrically lengthen the arms and legs of patients with dwarfism. Though the procedure has become safer and more effective over time, it is not without its risks — such as infection, stiffening of the joints or muscles, and nerve damage. Because few, if any, patients have reached middle age or older, the possibilities for long-term problems from the surgery aren’t certain.

The doctor who performed Caitlin’s first surgery, Paley, was the first North American surgeon to study with Ilizarov. Paley, who was born in Israel and raised in Canada, brought limb-lengthening to the United States in the mid-1980s and put it into practice as chief of the pediatric orthopedic surgery residency program at University of Maryland Medical Center in Baltimore. Along with two other orthopedic surgeons, Paley co-founded the International Center for Limb Lengthening at Sinai Hospital in 2001. Roughly 100 dwarfs undergo limb-lengthening at Sinai every year.

Though bilateral lengthening can be performed on adults, for children with dwarfism, particularly achondroplasia — the most common form of dwarfism — the optimal time to begin lengthening is around age 8, Paley says. The legs are lengthened first, generally by about four inches. The bones must fully heal before the next surgery, which takes place around age 12 or 13, adding another five or six inches of length to the legs. One year later, the upper arms are generally lengthened by roughly three inches, to keep the patient’s overall stature proportional. Some patients opt for a third and final procedure to lengthen the legs again by an additional four to six inches, at age 15 or 16. Each procedure — which includes all surgeries and physical therapy — costs from $200,000 to $300,000, and the expense is largely covered by most insurance plans. The medical claims for Caitlin’s procedure totaled almost $300,000; her family paid about $9,000 out of pocket.

A height increase of up to 16 inches is, Paley says, “a tremendously life-altering functional improvement.” But not everyone views the additional height with the same sense of appreciation. As the number of dwarf patients seeking limb-lengthening has grown, so has the controversy surrounding the physical, emotional and social impact of the procedure. Many members of the dwarf community believe that limb-lengthening sends the wrong message: that in order to fit in, be professionally successful or simply lead a “normal” life, it is necessary to conform to the larger population’s standards of height.

This perspective is fueled in part by a painful history of exploitation and social isolation. The cultural identity of dwarfs has evolved significantly since the early 19th century, when “midgets” — considered a derogatory term — were primarily considered social outcasts, circus performers or curiosities for public display. But even now, with dwarfs living and working successfully throughout society, there are still lingering stereotypes and reminders of how dwarfism has been linked with degrading humor. Consider “Mini-Me” from the popular Austin Powers movies, “Wee Man” from MTV’s “Jackass,” or the practice of dwarf-tossing, wherein dwarfs dress in padded Velcro suits and helmets and allow themselves to be tossed in bars or clubs for laughs. A French dwarf named Manuel Wackenheim famously argued that dwarf-tossing is a personal choice and a legitimate source of income, but the United Nations’ human rights committee determined otherwise, supporting a French ban on the activity in 2002.

The official position of Little People of America, which has more than 5,000 members, has evolved along with the developments in the field of limb-lengthening over the last 15 years. Originally skeptical, on the grounds that the procedure was risky, experimental and potentially harmful, the current standpoint of the organization stresses that it is a matter of personal choice — but also notes that the surgery is generally performed for “adaptive” or “cosmetic” reasons.

“When we try to change our height, we are changing who we are in order to better navigate the social and physical barriers that we face,” says Gary Arnold, vice president of public relations for LPA. “But in my opinion, the answer is not to change our bodies. The answer is to impact the world in which we live.”

Arnold reiterates that prospective patients should be old enough to participate in, and fully understand, the complex decision-making process. But that position creates a logical dilemma. The procedure is ideally first performed on someone too young to give informed consent. How is this ethical collision resolved? In Caitlin’s case, it was resolved by tacit compromise; when she became a teenager, Caitlin made her own choice, informed by the 13 years she had lived as a dwarf. In many other cases, including that of Rachael Whitehead, a 14-year-old Canadian patient at Sinai with achondroplasia, the initial decision was made by someone else.

When Rachael walks into a room on crutches, it is difficult to picture her as a young woman with an original projected height of only four feet. After four rounds of surgeries, with three inches of length added to her upper arms and 15 inches added to her legs, Rachael now stands 5-foot-2 and is nearing the end of her final lengthening procedure.

Rachael’s mother, Esther Whitehead, decided to have Rachael go through the first surgery, adding four inches to her height, at age 7. Whitehead believed that after one round of lengthening, Rachael would know enough of the experience to determine whether she wanted to do it again.

Sitting with her daughter in the common room of the Hackerman-Patz House, a campus home-away-from-home for patients who travel long distances to have their limbs lengthened at Sinai, Whitehead says that after Rachael’s first surgery, she was still about the same height as an average male dwarf. As to whether she was certain that Rachael wanted the procedure as a child, Whitehead says firmly: “Children frequently change their minds. We felt this was the best option.”

When Rachael started asking questions about her height as a little girl, Whitehead took her to Little People of America gatherings, so she could begin to get a sense of what life might be like if she remained short-statured in adulthood.

“I wanted her to see that dwarfism isn’t cute forever,” Whitehead says.

Rachael chose to continue the surgeries. She wanted the added height, she says, because she believed it was the only way to live a normal life. Without surgery, she says, “your adulthood would be ruined, and that’s a lot longer than your childhood. This way, you can live your life and not be stared at.”

***

The living room is filled with brightly colored streamers and balloons, and a pink cake box sits on the counter in the kitchen. Caitlin, who is celebrating her 14th birthday today, is dressed in a striped shirt, sparkling black headband and a loose cotton skirt. She is only two weeks away from the surgery to remove her fixators. She remains vague about whether she plans to continue lengthening — arms or legs — but the possibility seems increasingly doubtful as she nears the final stage of her first procedure.

When the first cars appear at the crest of the hill and wind down the long driveway, Caitlin — who can now stand and walk for brief periods using a walker — rises to greet her guests outside. Caitlin’s movements are jerky, her stance forced unnaturally wide by the devices anchored inside each lower leg.

“You okay, Cait?” Jennifer asks quietly, opening the door for her daughter.

“I’m fine,” Caitlin replies sharply, and she stiffly quickens her pace.

“Okay,” Jennifer sighs. “I won’t be the helicopter mother.”

Still, as she talks with other parents, Jennifer keeps her eyes trained on her daughter. While they wait for the rest of the girls to arrive, Caitlin and four of her friends gather in a circle at the foot of the driveway, kicking a soccer ball and giggling about boys, cellphones, beauty products. Caitlin looks her age beside these girls, who are also 13 or 14 but appear older, dressed in baby tees and fitted jeans with cellphones and lip gloss tubes bulging in the back pockets. They pass the ball to Caitlin almost every other turn — gentle kicks that Caitlin can catch against the toe of her shoe. One of the girls accidentally sends the ball rolling into Caitlin’s walker.

“Oh, my God, I’m so sorry,” she exclaims.

“It’s okay,” Caitlin says, blushing slightly. She plants her arms on her walker and lifts her feet off the ground to nudge the ball back into the circle. Behind her, Jennifer winces, but she doesn’t intervene.

A half-hour later, while the party waits for Caitlin’s stepfather, Mike, and her brother, Jackson, to arrive with pizza, Jennifer sets up Dance Dance Revolution — a Wii video game with interactive floor mats that allow players to move along to the dance instructions on the screen. Caitlin supervises from her seat on the edge of her bed.

“I can try it,” she says suddenly, assertively. It’s a sensitive subject, as Jennifer made it clear before the party that Caitlin would not be allowed to play the game — the mats are slick plastic, and a fall could be disastrous.

Jennifer turns to her. “No, you can’t, Caitlin,” she says. “We didn’t go through six months of this for you to slip and fall.”

The two look at each other steadily for a moment. Jennifer exhales through pursed lips. “Look, let someone else go first, and we’ll see how slippery it is,” she finally allows.

Caitlin holds the game’s remote control as two of her friends stand up to play the first round. Through the screen door, one more car appears at the top of the driveway — the last party straggler — and Jennifer steps outside to greet the new arrival. Caitlin waits for the screen door to slam shut behind her mother.

“Hey, I can do it now!” she says. She stands and moves to one of the mats. Holding tightly to her walker, she starts a new game and begins to move her feet in rhythm on the mat. Her friends smile nervously, but the interlude doesn’t last. Outside, the car pulls away, and the screen door opens again. Jennifer stands in the entrance, her eyes wide when she sees Caitlin on the mat.

“Caitlin!” Jennifer shouts, but her expression quickly softens as she watches her daughter move with careful deliberation to keep pace with the game.

“I won’t slip; I’ve got my walker,” Caitlin tells her. Jennifer relents, and Caitlin does one more round with her friends. When the game ends, she sits back down on the edge of the bed.

On the couch, a handful of her friends are discussing the actor Orlando Bloom while they examine each other’s cellphones. Two other teens are giggling on the mats as they follow along with the game. Amid the flurry of activity, Caitlin seems alone for a moment, lost in the images on the screen. Her fingers tap against the handles of her walker, and her feet move slightly to the front, to the side, back again, as she mimics the movement of her dancing friends.

***

In the pre-op area at Sinai, Caitlin sits in a hospital bed, drumming her fingers against the mattress. It’s the day she has been waiting for, and she is both excited and nervous. Wearing a T-shirt printed with the famous refrain from Dr. Seuss’s “Horton Hears a Who” — “A person’s a person, no matter how small” — Caitlin is flanked by her parents as a middle-age nurse reviews her chart.

“Any loose teeth or contact lenses?” the nurse asks. Caitlin says no.

“What about body piercings?” asks the nurse.

Caitlin squints and tilts her head, smiling mischievously.

Jennifer cries, “She’s kidding!”

Stewart’s gaze is locked on the pins protruding from his daughter’s legs. “She has 24 body piercings,” he says, wryly.

Shortly before 8 a.m., Caitlin is wheeled into the large, state-of-the-art operating room, designed to accommodate limb-lengthening and reconstruction surgeries. X-rays of Caitlin’s legs are mounted on one wall. A narrow table draped in blue cloth displays rows of meticulously arranged, gleaming surgical instruments. A nurse positions a mask over Caitlin’s nose and leans down slightly, near Caitlin’s ear. “It’s a dream,” she says softly. “When you wake up, you’ll be a new woman.”

Caitlin’s eyes flutter and close, and Jennifer is escorted from the room. Shawn Standard, who will be leading the surgery this time, takes his place at Caitlin’s side. Another doctor stands across the table, and both begin to unscrew the fixator frames. The clunky black devices are removed easily, and soon only the 24 metal pins are left protruding from Caitlin’s legs.

“It takes hours to put these things on,” Standard says of the pins and frames, “and it takes about 15 minutes to take them off.”

One by one, the pins are unscrewed and pulled free of Caitlin’s thighs and calves, clinking as they are dropped into a bucket on the table. By 9 a.m., less than half an hour after Standard entered the room, all of the pins are out.

Outside the OR, two hours pass before Stewart and Jennifer receive an update on Caitlin’s progress. The news is mixed: Despite Paley’s earlier prediction, Standard has decided to err on the side of caution and place titanium rods in both of Caitlin’s femurs, to stabilize the bones and help maintain alignment in the event of a fall or fracture. Jennifer rubs her temple. “Caitlin’s not going to be happy,” she says. This also means another surgery, as the rods are generally removed within six months to a year.

The two settle into chairs in the waiting room and talk about the years of deliberations that led Caitlin to surgery.

“When she decided,” Stewart says, “I said that it would be the end of her childhood.”

“I think her childhood ended a couple years ago,” Jennifer counters, “when she started to really realize and face the fact that she was different.”

Standard emerges from the OR to speak with Jennifer and Stewart at 12:30 p.m. “She did really well,” he says immediately. He adds that if Caitlin has her arms lengthened in the spring, he’d plan to remove the rods in her legs at the same time.

After Standard leaves, Stewart looks at Jennifer. “So the rods will come out when she does her arms,” he says. Jennifer shakes her head. Though Caitlin has not definitely decided, and she still has another couple of months before she would need to schedule a surgery for the upcoming spring, Jennifer says that right now, Caitlin doesn’t think she’s going to have more surgery.

This development comes as a surprise to Stewart. “I thought that was a done deal,” he says.

Jennifer leans back in her chair. “Caitlin can function with her arms. For Caitlin, she just wants to be able to function.”

“Yeah,” Stewart adds, “but she also wants to be as close to normal as possible.” He pauses. “Well, it’s her decision.”

“It always has been,” Jennifer says.

***

Caitlin didn’t know any other dwarfs as a child. All of her friends and family members were average height, and Caitlin never participated in meetings or activities within the dwarf population — something that both she and Jennifer view with a tinge of regret. Before she met other patients like herself at Sinai, Caitlin’s sole connection to little people was through movies and TV. She has developed a sense of the dwarf community by watching The Learning Channel’s “Little People, Big World,” a reality show that follows a family of both little and average-height individuals.

Dahlia Kronish, a 30-year-old ordained rabbi and high school teacher, lives that reality. Kronish — like Caitlin — is the only dwarf in her family. And like Caitlin, Kronish was presented with the option of pursuing limb-lengthening when she was a teenager. But Kronish had grown up with a strong connection to the dwarf community, through Little People of America and through a similar organization that her parents founded after the family moved to Jerusalem, when Kronish was 18 months old.

Nestled on a sofa in her New York City apartment last February, Kronish explains that she was 16 when she first met with a surgeon in Israel who described the lengthening procedure, still in an early stage of development. When the surgeon detailed how they would break and drill pins into Kronish’s bones, her mother fainted.

Kronish saw another surgeon a year later before telling her parents that she didn’t want to have her limbs lengthened. Her family, she says, supported her choice.

“I had learned to cope with being stared at and receiving different treatment,” she says. “Even if I wished — which I often did and still sometimes do — that it would have been better or easier if I wasn’t this way, I still wasn’t interested in a whole new identity at age 16.”

Kronish’s cheerful apartment on the Upper West Side is a testament to the identity she chose to embrace. There are stepstools in the kitchen so that she can reach her countertops and sink. The shelves above the counter are bare or sparsely occupied by items she seldom uses; dishes are stored in a low cabinet. A bookshelf in the living room displays a framed photo of Kronish laughing with her fiance, Josh Maudlin, who is also a dwarf. She avoids the subway, where the crowds are overwhelming and the steps are an exhausting strain. Instead, she drives a car with removable extensions to reach the pedals and pillows to push her forward in the seat so her hands can grasp the steering wheel.

Kronish, who served as president of the New York City LPA chapter for a year, has been thinking about how she’ll share a dance with her father at her wedding in June. She’s considering options — perhaps a raised platform she could stand on — but worries about looking awkward.

Kronish teaches rabbinical studies to students in ninth, 10th, and 12th grades at the Abraham Joshua Heschel School on the Upper West Side, and each year, she offers her students an opportunity to comment frankly about her height. She tells them about her choice not to pursue limb-lengthening and answers their questions.

This time, when she asks five of her high school seniors to share their thoughts about the impact of her size in the classroom, the students immediately recall a painful moment from the beginning of the 2007 school year.

Faculty and students gathered on the first day of school in September for a “welcome back” breakfast. To help spur excitement for the new academic year, the school hired a standup comedy troupe. For one skit, the troupe invited two students to join them before the group; the comedians would perform a scene and then pause, asking the students to suggest a word or phrase that they would then incorporate into the act. When the comedians turned to one of the two students, a senior known for his good-natured sense of humor, the student blurted out the phrase “midget-tossing.”

The room of 250 students and 50 faculty members grew very quiet, but the comedians promptly let loose with a string of jokes about “midget-tossing.” The student, realizing his own blunder, tried unsuccessfully to change his suggestion. After a few moments, Kronish stood up and walked out of the auditorium.

“I couldn’t handle it,” Kronish says later. “I was tearing up.” She refused to cry in front of her students.

The school principal, mortified, followed Kronish into the hallway along with two other faculty members. A few moments passed before Kronish composed herself and returned to the room to lead the gathering in the after-breakfast prayer.

“That was the hardest thing I’ve ever done,” she says.

When the class is dismissed, Kronish stands and follows her students out into the busy hallway, making her way to a teacher’s meeting. In the classroom, pasted above the blackboard, is a printed quote by author and Buddhist teacher Sylvia Boorstein:

“There are only two possible responses to every challenge — balanced acceptance or embittered resistance. Acceptance is freedom. Resistance is suffering. We all know this.”

***

In the food court of Bowie Town Center, Jennifer zips Jackson’s backpack and eyes her daughter, reminding Caitlin of the objective of today’s shopping trip: “You need pants.” Caitlin, armed with a small roll of cash tucked in a bright pink wallet, is eager to part ways and head off in search of her long-awaited new jeans. She’s been pining for real pants for months.

Stepping outside into the cold, overcast afternoon, onto the busy sidewalks of the outdoor mall, Caitlin immediately heads toward the stores on the other side of the street. It’s been two months since the surgery to remove her fixators and over a month since she stopped using a wheelchair, and her gait is somewhat stiff. She has physical therapy three times a week, which is still painful and exhausting. But now she is beginning to appreciate the results. “I’m not the shortest kid in my class anymore!” she announces. Time has begun to soften the hard reality of what she went through, and she’s not as quick to say that a second procedure is out of the question.

The first store on Caitlin’s list is Wet Seal, a prime destination for teenage girls. She opens the door to a blast of heat and punk rock music. The walls of the store are covered to the ceiling in tees with brightly colored sequins and sassy messages: “My Boyfriend Is Cuter Than Yours,” “I Don’t Like Your Girlfriend” and “Love, Peace and Party.” Caitlin heads toward several long shelves of jeans.

She’s not sure what size she is — she’s gotten taller and lost weight over the last eight months — so she grabs several pair, ranging from size 0 to size 3 (all designated “short”). On the way to the dressing room, she passes a rack of boots and shoes. She pauses in front of a pair of black, lacy, open-toed shoes with a skinny three-inch heel. “These are so cute,” she says.

In the dressing room, the size 0 turns out to be a bit too snug, and the flared bottom of the pant almost covers her entire foot; the 5 inches she’s gained since March make a big difference, but the pants are still slightly long. Caitlin changes into a pair of black jeans — size 1 short — and opens the door with a euphoric grin.

“They fit!” she declares, running her hands down the outside of her thighs, over the places where rows of metal pins jutted from her flesh two short months earlier. “I know my size!” she says and studies her reflection in the dressing room mirror. “I have a size.”

***

This past summer brought a chance for a new beginning: Caitlin’s family bought their first home and moved to a shaded neighborhood in Alexandria. It’s a big change from the sprawling fields surrounding their rented house in Clinton, and a shorter commute for Jennifer, who is working long hours again as managing director of office services at the law firm Hogan & Hartson in Washington. Early into her freshman year at a new high school, Caitlin is still adjusting to the routine and making friends. She’s glad that she didn’t undergo surgery in the spring, which would have meant starting high school with fixators on her arms. So far, only one classmate has asked about the scars running along her thighs and calves. Caitlin said they were from a car accident.

“A lot of people don’t really understand,” Caitlin says. “I’m just so afraid that people might think that it’s a plastic surgery and wonder why I went through that just to be taller. I really don’t want people to think that about me.”

It’s an irony that is not lost on Jennifer. The skeptic who feared that Caitlin would choose to have surgery because of social pressure, Jennifer now worries that Caitlin may delay or decline it for the same reason.

At a follow-up appointment a few months ago, Paley urged Caitlin to consider additional lengthening, reminding her that the procedure would be most successful while she is young. But for now, she has no plans to go through the process again. It’s an uncommon choice, he says, so uncommon that Paley has little doubt that Caitlin will change her mind.

“She needs to get her normal life back, and then . . . she will decide to do it again,” Paley says. “They all do. The number of patients who have not gone through a second lengthening is very, very few.” With the pain of the process behind them, Paley contends, patients quickly come to value the end result and usually decide that it’s worth the temporary sacrifice.

But surgery, Caitlin realizes, didn’t change everything; it didn’t “fix” the fact that she feels different among her peers. She still sometimes finds herself on the sidelines among her friends, and she can’t always relate to their interests and priorities. Her experience — growing up with a unique set of social challenges and limitations, and her decision to test her emotional, physical and psychological limits to gain the functionality she wanted — has given her a sense of perspective beyond her years.

“My personality is different,” she says. “I don’t like drama; I don’t like talking about people. I don’t fit in that way.”

***

Since the family moved to their new neighborhood, filled with kids and bike trails, Caitlin’s stepfather had been determined to buy Caitlin a new bicycle. She didn’t want one. She tried riding a friend’s bike a few months ago, she told her parents, and it didn’t work out; after a few shaky attempts to pedal a bike that was too big for her, she gave up. Still, Mike was insistent: new start, new bike.

So a week before her 15th birthday, on a stormy afternoon, Caitlin and her family drove to Toys R Us. Caitlin was not thrilled about where they were shopping, even though the store had a larger selection of bikes with 24-inch tires; she thought most of them were ugly, with childish colors. She wore her sunglasses inside. Embarrassed and eager to leave as soon as possible, she chose a dark purple bicycle.

Mike assembled the bike at home as the storm outside began to quiet. When the rain finally stopped, Caitlin decided to give it a try. She stood on her toes and climbed onto the seat. It fit her perfectly.

In the beginning, she concentrated hard on maintaining her balance, pushing the pedals awkwardly as the bike wobbled across the wet pavement. But soon the movement felt like second nature; she stopped concentrating and began to simply ride. She picked up speed, circling back to pass her mother, who stood watching. The look on Caitlin’s face, Jennifer says, was profound happiness and relief.

Caitlin kept going, clutching the handlebars and pedaling furiously. Jennifer watched her go faster and faster, rounding the bend in the street and disappearing from her view.

Caitlin Gibson, legal administrator for The Post, is a writer who lives in Bethesda. She can be reached at gibsonc@washpost.com.