Electromagnetic Stimuli and Resonance Frequency Vibrations For Tissue Transdifferentiation
I was recently listening to this episode where a person went on the radio to talk about how the late Nikola Tesla proclaimed that most of the universe’s hidden secrets can be found if a person would approach his analysis through the lens of looking at the world from a perspective of it being electromagnetic stimuli, energy, frequencies, and vibrations. The most famous quote to this claim was “If you want to find the secrets of the universe, think in terms of energy, frequency and vibration” – Nikola Tesla.
When I think back to this claim, I feel that there is probably more and more evidence that the proclamation is right. I remember back during my undergraduate days studying the higher level of classical mechanics. Beyond say the introductory physics course where we are asked to solve for different variables using the ideas of forces and momentums, it is possible to be much more mathematically elegant to solve the same problems using the principle of just energy alone.
For example, the Lagrangian formulation/interpretation of solving the problems of classical mechanics can be done on the principle of finding the path for the state or motion of least action. At the core of this entirely new approach on calculating say the motion of movement of a system being studied is the Langrangian Function which is really just the sum of the kinetic energy and the potential energy, either from a set initial point to an end point, or a set initial time point to a end time point. The function is L=T+V. The letter T represents the total kinetic energy of the system and the letter V represents the total potential energy of the system. What you get eventually is a large 2nd order differential equation you have to simply and solve for the value you are looking for. We obviously are not going to get into the mathematics of any physics in this post, but just explain the principles using words.
In addition, here is something known as the action of the system (S), which is defined in words to be “The summation of the Langragian function over time from an initial time point to an end time point” aka calculus integral function. The goal when you are solving a system is to figure out which path or state of the system would minimize that S.
One of the main reasons why this way of calculating motions, states, and other variables of the system is that by using just the principle of energy (Kinetic plus Potential) we don’t have to worry about the transition from one cartesian coordinate system into another. Remember that the original Newtonian way to calculate forces and motion required that you use the concept of vectors, which had a standard 3 parts to it. With this way, you can calculate out a single value with a single numerical value or symbol instead of having it in 3 parts. For more information on what the hell I am talking about Click Here.
Getting back to the Main Point…
Beyond just giving a short explanation on physics, what I am hoping to show the reader is that the principle of energy can often be used to explain away phenomena as well as be used as a tool to solve problems which might be too hard in another approach.
In the same way, we can use the idea of waves, vibrations, frequency, and vibrations to explain certain phenomena that say using the traditional approach. Remember what happened in the Double Slit Experiment. A light source was shined through some type of solid pain with two parallel slits. You are looking at the wall or the surface behind the pane and if you see interference then the phenomena that is first reaches the pane has characteristics of a wave. The ramifications of the experiment showed that wave phenomena has properties of both wave and particles. This implied that particles (at least the very small ones) have characteristics of waves as well. Since we are using principles of frequency, wavelength, etc. to describe what could be considered another area of physics, we could use intuitive reasoning to extrapolate this idea that all phenomena could be explained using a waves and vibrations view of the dynamics of the universe. If that is the case, then maybe we could use waves and vibration stimuli to solve many engineering problems as well as medical problems.
What I am overall trying to get at is that maybe the simplest way to induce a statistically impossible biological process to happen, all we need to do is figure out what is the optimum level of energy or frequency, what is the right type of energy or stimuli to use, and what location we need to use it on.
When I look back at all of the ideas I have proposed over the last two years on how we might be able to get bones to grow again, I have gone through almost every single idea. Here is a list of most the types of stimuli I have looked into.
- Extracorporeal Shockwave Therapy (ESWT)
- Pulse Electromagnetic Field Therapy (PEMF)
- Low Level Laser Therapy (LLLT) – This is also known as Cold Laser Therapy
- Low Intensity Pulse Ultrasound (LIPUS)
- High Intensity Focused Ultrasound (HIFU)
- Magnetic resonance-guided focused ultrasound surgery (MRgFUS)
- Emitting at the frequency of the bone’s resonance for decalcification of the ECM (Extracellular Matrix)
In my most recent seminal post about using a combination of silver acupuncture needles as a form of electrode to transmit a very small intensity level of Direct Current to stimulate cartilage and the periosteum to increase their size, I had used over a dozen old studies and citations of experiments done by researchers from back in the 80s to validate the concept. The PEMF technology I described would work with around 95% confidence in over its efficacy.
That post was “Electromagnetic Stimuli Will Increase Ossification and Make Bones Longer, Big Breakthrough!“
I had previous showed that it might be possible to induce the bones to increase the rate of endochondral ossification with something as simple as a Function Generator or even a TENS Unit which often cost less than $100.
Take a look at the older post “Do We Use A TENS Electronic Pulse Massager or A Function Generator?“
At this point I have no clue what could be the biomolecular reason why sending something as simple as a pulsed electrical signal at a signal could induce human tissue of all varieties to have some type of effect. If we actually think about it, it should make perfect sense. Just think about what actually makes the human brain (or any brain) work anyway. The fundamental unit of the nervous system is the neuron, a nerve cell. (Sure you have stuff like the Ganglia but that is not the point.) The whole point of the neuron is to have the dendrites on the neuron cell body to integrate (add up over the surface) all of the biochemical signal into a type of voltage potential. When all the built up potential reached in the neuron to a certain threshold, an electrical current is fired from the cell down the axon, to the tips, which are close to the dendrites of other neurons.
The same can be said for the human heart. If we remember our introductory CPR class, the whole reason for pushing in a rhythmic fashion on the chest is to get the heart to beat again, so that the heart can act as a type of biological pump to push the blood through the vessels around the entire body to feed the tissues who always need ATP. When the Paramedics (or EMT) first gets to a body of a person who is not responding and/or unconscious, they check to see if they are breathing and has a pulse. The indication of a pulse, means that the heart in the person’s body is at least doing its job of pumping the blood, nutrients, minerals, and oxygen around to sustain the cells and tissues. If the heart stops, there is no pulse.
The heart operates actually on a very clear rhythm of electrical signal. For the people who have ever had an ECG (Electrocardiography) done, they have probably been told that what is being measured is the electrical signal that is coming from the heart beating. If there is some type of irregularity in the heartbeats, this is known as arrhythmia. To correct for it most people get some type of internal Implantable Cardioverter Defibrillator. If however the person is already on the ground, most emergency rescue personnel with some type of advanced life support (ALS) or basic life support training (BLS) will use some type of portable external defibrillators to reset the rhythm of the heart beating. What we are trying to say is that at the most basic level, our most important internal organs, the brain and heart, both operate on electrical current.
In one of my most recent posts Tyler said that what I was proposing, the changing of the bone tissue into cartilage tissue would be cell transdifferentiation. I countered to point out that if we are trying to regenerate epiphyseal growth plate cartilage tissue from bone tissue, it would not be enough. Even if we could do the transdifferentiation step, we still have to figure out what to do about the other biological, molecular, organic, and nonorganic material in the extracellular matrix of the bone. We might not need to worry about some organic and biological compounds like the collagen and proteins but we do have to worry about the inorganic compounds and minerals. The most common problem would be the Calcium Hydroxyapatite crystals which is the mineral that is causing the bones to become so strong and have such a high level of compression strength.
There are two things we have to induce.
- Changing the terminally differentiated osteoblasts and osteoclasts into chondrocytes
- Removing the minerals and inorganic compounds in the bone composition that causes the defining characteristic and properties of bone tissue.
However, it would probably be much easier to do the 2nd process. We have already shown in previous posts that using something as simple as Vinegar (Ascetic Acid) covering bone would be enough to chelate the hard minerals. This is known as bone decalcification. The hard part would be the first part.
How do we turn one type of cell into another?
The basic idea proposed by Dr. Robert Becker from his book (which I am still reading) shows that besides say the red blood cells which have no nucleus and the gametes which have just have the number of chromosomes, most cells in the human body does have dormant genes which are no longer turned on beyond a certain stage in prenatal development of child growth. How and why those genes are not turned on has not been figured out yet. What this suggest to some of us hopefuls is that idea that maybe using some type of stimuli, which I propose in this post to be electromagnetic or vibrational wave in nature, targeted in the right way could reactivate those genes again. If the same gene or microRNA in enough cells are activated, it might mean that we can get transdifferentiation to work and get one cell to possibility turn of the trigger causing them to become bone cells and turn on the one causing them to directly turn into cartilage cells aka chondrocytes.
I suspect that we might be able to use pulsing electrical stimuli or some type of ultrasonic high frequency, low intensity waves to stimulate the cells to go through transdifferentiation in an non-invasive approach similar to how using the MR Guided Focused Ultrasound Surgery works.