Understanding Growth Plate Fusion(and growth plate senescence) will help us understand if these processes can be reversed. And just as a note I am still working on devices and methodology to grow taller.
A Computed Microtomography Method for Understanding Epiphyseal Growth Plate Fusion.
“The epiphyseal growth plate is a developmental region responsible for linear bone growth, in which chondrocytes undertake a tightly regulated series of biological processes. Concomitant with the cessation of growth and sexual maturation, the human growth plate undergoes progressive narrowing, and ultimately disappears. Despite the crucial role of this growth plate fusion “bridging” event, the precise mechanisms by which it is governed are complex and yet to be established. Progress is hindered by the current methods for growth plate visualization; these are invasive and largely rely on histological procedures. Here, we describe our non-invasive method utilizing synchrotron X-ray computed microtomography for the examination of growth plate bridging, which ultimately leads to its closure coincident with termination of further longitudinal bone growth. We then apply this method to a dataset obtained from a benchtop micro computed tomography scanner to highlight its potential for wide usage. Furthermore, we conduct finite element modeling at the micron-scale to reveal the effects of growth plate bridging on local tissue mechanics. Employment of these 3D analyses of growth plate bone bridging is likely to advance our understanding of the physiological mechanisms that control growth plate fusion.”
“It is the terminally differentiated hypertrophic chondrocyte, which mineralizes its surrounding extracellular matrix. This process, thought to involve membrane-limited matrix vesicles, is biphasic and tightly regulated by a number of enzymes and factors including alkaline phosphatase (Alpl), PHOSPHO1, the ankylosis protein (Ank), ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (Enpp1) ”
“as growth slows, the human growth plate undergoes progressive narrowing as bony bridges form and span its width. This ultimately leads to complete growth plate closure and the cessation of human growth. These bone bridges are also known to form upon growth plate injury, thought to be through an intramembranous ossification mechanism”
“in two genetic mutations resulting in estrogen deficiency (in the estrogen-receptor gene, and in the CYP19 gene), the growth plate fails to fuse and growth persists, albeit rather slowly, into adulthood”
“Evidence from studies in both humans and rats revealed the cessation of growth long before any histological evidence of growth plate fusion, suggesting that epiphyseal fusion is a marker of growth cessation and not its cause “<-Thus it may be possible to renew growth plate growth by reversing cessation and not fusion.
“young (8 weeks old) CBA wild-type mice, growth plate bridging is associated with locations that contain high local von Mises stresses. Moreover, we reveal that with aging an increased number and density of growth plate bridges is observed”
” in wild-type mice, increased growth plate bridging translates into increased stresses in the bone directly beneath the growth plate.”<-So maybe these stresses contribute to growth plate closure.
“At 8 weeks, few bridges are detected and overall the growth plate is squeezed in a “sandwich” configuration. This suggests that compressive hydrostatic stresses are engendered across major volumes and that higher shear stresses are generated only at the peripheral edges of the growth plate. Yet, the results of numerous mechanobiological models support that growth and ossification is accelerated by tensile strain (or shear stresses) and that cartilage tends to be maintained by hydrostatic compressive stress“<-so for a longer growth period we need to encourage hydrostatic compressive stress.
Is there some new thing about clavicle widening? I keep seeing more and more Korean men with wide shoulders… any news on how we can widen them?
I think you should create something like patronite or indiegogo etc
We need to tell scientists:”Height growth is important.You should research about it.It is important than space”They didn’t make enough research about it.(They keep telling %80 genetics %20 rule.But we already know it.When we read their articles we understand this:They don’t care about it) If they make good research and if they find something,they can destroy %80 of crime in world(Rape,cheating,murder,bullying…).Short people’s life is harder than tall peoples.We need to tell them importance about it.Maybe after that they can find solution for beauty too.And this will stop selection about beauty in human nature.Scientists must stop saying that “It is impossible”.Because they can change human’s gender,make tube baby,clone…I believe they can find something about height too.
I don’t agree with you. Most of the people who have committed noticeable and evil crimes like rape or murder or serial killings are rather tall males. About the cheating, again, I don’t agree with you. I have a friend who is tall, has a nice body, handsome and he is so polite and rich. Yet, his wife has cheated on him. As with bullying, it’s not about height. Was Bruce-lee someone to be bullied? There are a lot of other people who are not your typical hell-tall, but are the ones who’s got a type of attitude that no one dares to knock their door or look at them sideways. Being short doesn’t mean that you’ll practically end up short in life. When reviewing the history, there are numerous men who were short but at the same time, great leaders too. Same about actors, musicians, businessmen and etc. So being short or tall has nothing to do with happiness, or cannot guarantee that your wife or husband will worship you till the end of the world and never cheat on you, and can’t save anyone from committing crimes or being bullied. No matter how much scientific evidences there are that says about being tall pays off, when they are nothing except a bunch of assignments that some people NEEDED to do for some REASON and don’t correlate with the real world, they are not SCIENTIFIC .What scientists need to take into consideration is that how could people increase their viewpoint’s height, the bigger picture of their life, not their physical height. If you want to increase your height try Zixia’s method and NAPs in the Merlin’s forum. I tried them and grew 10 cm after finding out in the x-ray pictures that my growth plates weren’t fused. I don’t know how this might work or worked, but it worked and it might be a good clue for scientists to start.
Your comments are closed on ligaments affecting bones or height. The ligaments restraining bone may be affected more from jarring or wrenching movements. There is specialized physical therapy that seems to address affecting ligaments in this manner to correct scoliosis and actually remolds bone and cartilage over time, search Gary Gray Functional Training & Fitness. I can go into greater detail but will await to see your response to this.
The content is blocked by a paywall and there’s a lot of it. Can you list some specific content?
I’ve had personal experience with the treatment I described. My rib cage, which was affected negatively, warped, by scoliosis more than my spine was, was reshaped initially, to some degree by the initial 10 physical therapist appointments which included intense targeted “massage” work plus exercises, but I was given about 15 exercises to continue every day, which were like wrenching and jarring of the ribcage that positively bent the sternum, cartilage and actual rib bones back towards the normal shape over a more than 2 year period. I’m still doing the exercises. It takes years to reshape the ribs but is well, well worth it. This is after, years ago, going through multiple physical therapists, multiple doctors, a chiropractor, and even a rolfer, 9 practitioners total with zero change or answers. The techniques are new and weren’t around when I was younger but are now and work on someone well past their teens, I’d imagine literally any age. It’s not conventional stretching, more like jarring, and it worked on the scoliosis because of the initial intense targeted massage, loosening type work and also one-sided exercises which addressed an imbalance in the right/left strength and tightness of upper and lower back muscles. The bottom line is that this was not regular “hold a position” stretching or a muscle “pumping” type of exercise. To me it would be like how a person would bend a pliable thin green tree limb by wrenching it one way and then the other until it bent.
This video was the first introduction I had towards this method and what got me researching and finding a physical therapist trained by Gary Gray’s methods in my area:
https://www.youtube.com/watch?v=9TWtrCmzaOw
Here are some Gary Grey videos:
https://www.youtube.com/user/GrayInstitute/
How does it work? Adjusting muscle imbalances? Loosening the ligaments? Using joint cavitation via back cracking?
The problem with adjusting the spine in this way is that the shoulders and everything else goes out of alignment.