Tachypleus tridentatus is also known as horshoe crab. According to The Beneficial Effects of Edible Kynurenic Acid from Marine Horseshoe Crab (Tachypleus tridentatus) on Obesity, Hyperlipidemia, and Gut Microbiota in High-Fat Diet-Fed Mice, compounds like Kyurenic acid could be beneficial effects of horshe crab.
“Tachypleus tridentatus (T. tridentatus) is a marine animal and traditional Chinese medicine. T. tridentatus plasma is a valuable resource for important medical and health-based functions. In this experiment, in order to evaluate the effect and mechanism of T. tridentatus plasma with respect to the promotion of bone tissue growth in rats, the processes of ultrafiltration and mass spectrometry were first used to separate and identify the components of T. tridentatus plasma. Then, a comparison of the effects of the T. tridentatus plasma samples, which each possessed different molecular weights, regarding the growth of the long bones of rats was conducted. Finally, transcriptomics, proteomics, and bioinformatics were all used to analyze the biological functions and related signaling pathways of the T. tridentatus plasma in order to promote rat bone growth. The results showed that the contents of amino acid residues in peptides are related to the growth promotion that was contained in the 10–30 kDa plasma group. Moreover, the T. tridentatus plasma samples were found to be higher in this respect than those in the whole plasma group. In addition, the 10–30 kDa plasma group could significantly promote bone growth activity in rats. The proteomic analysis showed that the proteins that were differentially expressed in the 10–30 kDa plasma group were mainly enriched in the PI3K-AKT signal pathway. Our study suggested that the T. tridentatus plasma possesses promising potential for the purposes of clinical use, whereby it can serve the role of a growth-promoting agent.“
The fact that they think that horshoe clab has clinical use is promising but we have to see what unique benefits it has over other compounds. Lots of things stimulate the PI3K-AKT pathway. We have to see if there’s anything the plasma does that is unique or superior in promoting growth.
“T. tridentatus possesses anti-inflammatory, analgesic, hemostatic, and antidysentery medicinal effects. It is also worth noting that T. tridentatus blood that contains hemocyanin possesses important medical application value. The blood extract can be made into a Limulus-reagent (LR), which is widely used for the purposes of endotoxin detection and quantification in injections, as well as in radiopharmaceuticals, vaccines, and other biological products”
“T. tridentatus plasma can promote the growth and development of Wistar rats by increasing body weight, body length, and tail length in adolescent Wistar rats; in addition, despite this range of growth, the rats do not appear obese.”
” IGF-1, BMP2, and ALP are applied to monitor bone growth indicators.”<-lots of things can increase those things. The question is does Horshoe Crab does anything that is unique?
“the plasma group showed macroscopic changes in total longitudinal bone length after 14 days of treatment. In addition, morphological changes were observed, such as the increased height of the growth plate area and an increased number of proliferating cells. Furthermore, T. tridentatus plasma treatment significantly increased the total serum levels of BMP-2, IGF-1R, and IGF-1, as well as induced the upregulated expression of IGF-1 and IGF-1R in the growth plate region.”
So the fact that scientists like that this compound can enhance longitudinal bone growth is interesting but the question is is whether it is really better than say other things in the diet?