Something I read from the reddit/r/short threads recently made me remember something I discovered years ago. It seems that male genitalia, (aka Penis Size) can be altered/increased through excess levels of hormones.

Whoever the poster was, I am guessing that they are feeling the symptoms of a pituitary related tumor, whether benign or malignant. The tumor is stimulating excess HGH release into their system.

Like they said they are already 26, which suggest that their normal growth plates should be closed. This recent events which are indeed unusual for most people doesn’t seem to surprise me. I had guessed that excess HGH can cause even people with closed growth plates to gain 1 full inch in height, just based on the fact that there are still thin slivers of hyaline cartilage tissue in their vertebrate, tibia, femur, etc. which goes through hypertrophy. When you combine all of the hypertrophy the hyaline articular cartilage locations goes through, the total increase in height would often be around 1 inch.

As for height increase, this guy went from 6′ 2″ to 6′ 3″. His height will most likely not increase any further. However, he stated the other fact. His genitalia increased{Tyler-One thing to note is the penis is considered to be like a hydroskeleton}. When I think about this, it all starts to make sense.

Let’s go back a little.

For the normal, average, heterosexual, American men, the most common insecurity might not be their size, in terms of height/stature, but their size as in their “genitalia”. There are in fact entire internet forums dedicated by young men who actively do exercises to increase the size of their genitalia. Since the forums seem to be quite active, I am guessing that these guys who have that pursuit are slightly more successful in their endeavor than ours.

I had proposed in previous posts the idea that stereotypes have in them kernels of truth. I theorized that the stereotype that African American males have larger than average sized genitalia is true. The reason that is the truth is because I guessed that African Americans have higher than average levels of IGF-1 which goes through their system when they are going through puberty.

Higher levels of IGF-1 suggests higher rates of cardiovascular system related medical conditions later in life (diabetes, prostate cancer) which also has a slight correlation to having an earlier than average puberty. I am not sure, but I think I remember seeing studies which show that African American females (at least in urban locations) goes through puberty around 0.5 years earlier than their Caucasian American counterparts. This gives them a slightly less time to grow, assuming all other factors in their growth progression is the same.

Let’s remember our endocrine system. Pituitary gland derived GH goes into the liver, which converts it to IGF-1 which goes to the chondrocyte area (growth plate) of bones making them longer. We also learned that IGF-1 can be created located in the tissue right next to the growth plate. IGF-1 is created in both areas.

If my theory on the link between African Americans and increased IGF-1 levels during puberty is true, it would explain the increase in tissue (size and number) that is not just in bones.

This guy who posted stated that he noticed himself growing again. The obvious guess is that his pituitary gland has gone into overdrive, secreting GH, going to the lier, converting into IGF-1 and that is what is contributing to making his genitalia larger.

Now, this is not the only way chemically. There are a LOT of other options for men to increase the size of their genitalia. (think Relaxin, Prostaglandin ES , Prostaglandin Alpha F2.). In fact, it seems that taking something as simple as Niacin or Nitric Oxide (found in most GNC stores) would be able to do that.

Here is what most people need to realize about growing tissue in their body. Pituitary Gland derived HGH can grow almost all forms of tissue in the human body except for bones, at least interstitially.

If you have ever seen most people suffering from acromegaly, or maybe gigantism when they were younger, they often have wider than average noses, and have wider than average upper torso. The GH going through their system is expanding the costal cartilage in their sternum and the fibrocartilage in their nose even when they are in their 30s, and 40s, of course in small levels.

In fact, analogous to how men in today’s American society worry about the size of their genitalia, American females are too concerned with their mammary gland organs (breasts).

Too many American females get plastic surgery to make their breasts larger, to supposedly give themselves higher levels of confidence/self-esteem. What they don’t understand is that nature (being the generous “mother” that she is) figures out a way to give females who have smaller than average mammary glands larger ones, once they have gone through the process of pregnancy.

In fact, the actress Mila Kunis went on the Conan O’Brien show recently and talked about her experiences in adjusting to the fact that her mammary glands have increased from pregnancy, and now she needs to wear a bra, which she has not had to do throughout her adult life before. So girls, stop going to the plastic surgeon. Just wait for pregnancy to do it naturally. Sure, there is also the added side effect of increased nipple and aereola size, which is for the baby’s mouth. However, the mammary glands definitely increase in size.

Some people might counter and say that the increase is not permanent. I agree on that point, since based on female menstrual cycles, the breasts’ size increases and decreases based on the monthly cycle. However, pregnancy does cause certain chemicals to go often, which have such a dramatic affect on the female body that often the physiological and anatomical changes are completely permanent.

(I am referring to the fact that many caucasian females who had blonde hair before throughout their entire lives had their hair color changed to becoming brunettes because of the release of excess melanin from pregnancy. In fact, you will find many stories of females who had their hair progressively get darker and darker over time after each pregnancy they go through.)

From pregnancy, women gain these changes in their body

• Feet size increase – Shoe sizes often go up by 1 full size, permanently. This is due to relaxin.
• Breast size increase – I suspect at least 25% of all women who have gone through multiple pregnancy would notice an increase in cup/bra size that is permanent.
• Hair color changes – Most pronounced in caucasian females. Light blonde hair turns progressively darker/more brown after each pregnancy.
• Body hair changes – Increased levels of hair on arms/legs. Also, hair might sprout up in areas of body which wasn’t there before.
• Hip size increase – Some medical profession might argue with me and say that certain women can never loss the extra 15 lbs they gain from their first pregnancy. They account hip size increase due to fat deposits that become an extra layer. However, I might argue against this and say that hip size increases can be due to realignment of the pelvic/sacroiliac girdle, causing the pubic symphysis to become stretched out.
• Height increase – Now, this is the phenomena which is most rare. I had guessed that this only happens to maybe 1 our of every 10,000 women.

Interestingly, just today some other woman commented on a previous post “Another Case Of Pregnancy Causing Woman To Grow Taller And Increase In Height”.

Let me show you guys just how often I get messages to this website to that post about this phenomena.

While I was doing chemical research for something else today, specifically on the possibility of starting my own chemistry based cosmetic company (similar to what Jessica Alba did with her Honest company to become a billionaire) I found myself looking into at the active ingredients of many of the most common items in one’s bathroom.

It took maybe 3 hours of checking, scouring, and reading (on Wikipedia) to figure out what exactly were the compounds found in my mouthwash, soap, toothpaste, hand lotion, and sunscreen.

Eventually I came across something that was lying on my bathroom medicine cabinet, Benadryl.

I once remembered a friend of mine telling me that you can knock yourself out by drinking a lot of Vick’s Nyquill (aka cough syrup), which has the active chemical compounds of the following below… (source)

Active ingredients (in each 15 ml TBSP) – Purpose

• Acetaminophen 325 mg  – Pain reliever/fever reducer
• Dextromethorphan HBr 15 mg – Cough suppressant
• Doxylamine succinate 6.25 mg – Antihistamine

Antihistamines are a very common type of drug. So from Vick’s Nyquill, I wanted to know the active ingredient of Benadryl. Does Benadryl have a similar effect as Nyquill, where if you take too much, you will get knocked out?

(Side Fun Fact: Interestingly, people often mistake the idea of chloroform as a drug used to knock people out, but it is actually Ether. Chloroform is talked a lot about in Movies, and shown used in Kidnappings, but Ether would be more effective, since it is faster acting on the human system)

(Side Fun Fact #2: Similarly, there is more than one way to make truth serum, which really just lowers people’s inhibitions and acts as a sedative, making them groggy. The recent news about thieves who steal from tourists using the NIghtshade derived Scopolamine and Atropa belladonna. You can also use Sodium Pentothial (aka Sodium Pentathol.)

So what are the active ingredients in Benadryl, the Anti-Histamine Drug most often used to treat allergies like hay fever?

Well, Benadryl is actually a Brand Name for something else, called Diphenhydramine. In the UK, the active ingredient would be acrivastine and/or cetirizine.

While I was doing more research into the compound Diphenhydramine, It led me to an article on Meclizine, aka Meclozine. Medical professionals knew about the bad side effects of Diphenhydramine for a while, and wanted a type of anti-histamine which did not have that type of drowsiness which comes with it.

In my own searching, I remember writing about Meclozine as a one of the most biggest breakthroughs we have made on this website. Tyler back in 2014 wrote a post entitled Game Changing Breakthrough OTC Height Supplement-Meclozine. I myself also wrote about it entitled Achondroplasia Treatment and Increase Height Using Meclozine aka Meclizine – Great News For Parents!

The science behind it seems to be valid. However, there have been a few sources we found on the internet which suggests the exact opposite. Study of possible correlation between BODY HEIGHT DECREASED and MECLOZINE (MECLOZINE)

This one source however does not take away from the multiple sources which show that Meclizine has bone enhancing abilities.

Google patents – Therapeutic agent for systemic bone disease and use thereof – WO 2014141847 A1

This patent was based on an idea to treat achondroplasia by having as one of the active ingredients Meclizine, which they noted is OTC (Over-The-Counter). These same inventors from Japan, wrote a piece called “Meclozine, Motion Sickness Medicine, Has The Therapeutic Potential In Achondroplasia” – (Masaki Matsushita).

It is interesting that Meclozine (aka Dramamine) has sort of replaced the Benadryl/Diphenhydramine as the type of antihistamine to use now.

It seems that Meclozine is actually so common, and easy to get that you can buy it from Amazon. Before, Tyler Linked to the chemical. Here it is again, for sale from Amazon for around $35. (No affiliate link)

Someone asked Tyler whether taking the Meclozine would work with people with closed growth plates. Tyler said that you should take it with doing LSJL. I will let the readers decide on whether it will work for adults.

However, for young children, this chemical seems to have noticeable effects, especially if you get the compound into your blood, and not through your digestive system (aka orally).

I was reading some random study in the field of orthopedics today and someone mentioned the condition SED, or Spondyloepiphyseal dysplasia congenita based Dwarfism, and that made me remember a few things that I had not looked at for a long time.

I remember people telling me about quack-pseudo-scientific ideas on how to treat SED before on other websites, but I wondered whether the Patent databases had anything written about treating it, in a more scientifically legitimate way. So I googled “Spondyloepiphyseal Dysplasia Congenita” into the Google Patent database to see what would come up.

Some of the first few results were obviously crazy, like the following “Drug composition for treating spondyloepiphyseal dysplasia – CN 103142900 A”. This patent apparently was only filed in the China based database, and it is based on a combination of strange vegetables, minerals, and plants. The idea from this ancient formulation I would guess is to reduce the curvature of the spinal or straighten it out, which would obviously give the person a little bit of height increase. However, I would not be willing to put money on an idea based on Traditional Chinese Medicine practices.

It would be the next search result, which really caught my eye. Refer to the patent “Variants of C-Type Natriuretic Peptide – US 20100297021 A1″. This was a patent which I don’t believe I have talked about before, and the name of it would not be an indication to most people searching the Patent Database that it is anything of importance, but this patent is basically a patent for a way to help people become taller.

Tyler and I have in our research throughout the years have seen multiple similar patents working on the similar idea which was also for increasing stature. 

Refer to the Abstract below….

The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).

The Inventor is a Daniel Wendt from Biomarin Pharmaceutical. If we need to remember, Biomarin was the company which made the BMN 111 compound, which is used to treat childhood achondroplasia. I remember reading about this drug maybe a year ago on a website that focused specifically on how to help cope with a child who has the condition.

As one can see, this patent was filed back in 2010 and it has been filed in the USA, Canada, Europe, China, and the World Patent Database System. If I was to guess, I probably had linked to this patent multiple times before, but never really read the patent thoroughly..

Refer to the sections in the patent which I will highlight below…

“….In contrast, mice engineered to produce elevated levels of CNP display elongated long bones and vertebrae.”

I would learn further that in the growth plate, the proliferative zone expresses a compound called NPR-B while the hypertrophy zone expresses NPR-C. CNP (which stands for C-Type Natriuretic Peptide) is an agonist for the NPR-B. Agonist just means some type of chemical or protein that assists or increases a biochemical process. Further down the chain of chemical processes (which in the chemical/medical industry call downstream), the CNP and NPR-B pathway causes the FGFR3 pathway to be blocked. Remember that Achondroplasia is most often caused by a mutation of the FGFR3 causing it to be overstimulated or extra-sensitive. In the FGFR3 pathway, there is a step in the MAPK section. It seems that the CNP/NPR-B disrupts the pathway at MAPK, causing the FGFR3 to become inhibited, thus removing the stunted height morphology.

Refer to the section below from the patent….

“In humans activating mutations of FGFR-3 are the primary cause of genetic dwarfism. Mice having activated FGFR-3 serve as a model of achondroplasia, the most common form of the skeletal dysplasias, and overexpression of CNP rescues these animals from dwarfism. Accordingly, CNP and functional variants of CNP are potential therapeutics for treatment of the various skeletal dysplasias.”

Something that I would further learn is that the plasma-half life of CNP in the human blood stream is very short, only 2.6 minutes (in-vivo). This means to get this biomedical technique to work out, the CNP would need to be continuously pumped into the subject’s body. Apparently the basic level of CNP in the human body is around 5 picoMolar (5*10^(-9) Molar). The level of CNP must be higher than this concentration.

Refer also to more sections from the patent…

“…In a further embodiment, the CNP variants are useful for increasing the size of the growth plate of a bone (e.g., a limb bone). In another embodiment, the CNP variants are useful for elongating a bone or increasing long bone growth. In still another embodiment, the CNP variants are useful for enhancing matrix production, proliferation and differentiation of chondrocytes.”

Apparently to make the femur longer at the highest rate, you want to use a variant of CNP known as N-terminal PEGylated CNP variant.

“…Ex vivo studies of cultures of mouse bones indicated that CNP37 was delivered to the growth plate and was able to increase chondrocyte cellularity and hypertrophy, which are associated with growth plate expansion and longitudinal bone growth.”

“…These results demonstrate that CNP variants of the disclosure penetrate into the growth plate of wild-type and achondroplastic animals, increase the number and size of chondrocytes, increase the thickness of the proliferating zone and the hypertrophic zone of the growth plate, and increase longitudinal bone growth in treated wild-type and achondroplasic animals. Therefore, the CNP variants are useful for stimulating bone growth in achondroplastic subjects.”

There apparently was even news stories published in the Major Online News Websites talking about this drug/invention. (Note: Yes, I am fully aware that I am assuming that the patent I found is referring to the Vosoritide/BMN 111 chemical compound)

Drug Accelerated Growth in Children With Dwarfism, Pharmaceutical Firm Says – 6/17/2015 – The news reported that children would be growing around 6 cm/year than 4/cm by taking the drug. The other name for BMN 111 is vosoritide. There has been questions about the efficacy of this chemical after the first year of use, and whether after the first year the drug would still be as effective as the first year. In addition, it seems that people who did not suffer from Achondroplasia did not get any type of increased bone longitudinal growth benefit from using it. Since the article was written back in June of just this year, the drug is now in Phase 3 Trials, where around 50-150 children will be subjects for this new treatment.

BioMarin drug boosts growth in children with dwarfism – the source here seems to make a correction on something the previous source said, which is that the 6 cm of increased height is actually from just 6 months of tabulated data, not a full year.

BMN 111 (vosoritide) Improves Growth Velocity in Children With Achondroplasia in Phase 2 Study – This source suggest that the efficacy of BMN 111 will continue past the 6 month range in Phase 2 –

• There was a dose-related increase in urinary excretion of cGMP measured over the 6 month duration of the study. cGMP is a biochemical marker that may indicate that BMN 111’s  biological effect will continue beyond 6 months.

Refer to the chart from the source below….

It would seem that National Health Industries and Organizations will not fund for a condition unless it has been diagnosed as a real medical condition or a disability. Short stature is not technically a disability, but having achondroplasia or dwarfism does qualify as a medical condition. This is where biomedical research will go and the funding will flow towards.

If you guys are interested in learning more about this compound, just type in the common name for it, Vosoritide or BMN 111. Biomarin even has itself listed on the Nasdaq under the acronym BMRN.

Note: If you really want to see the video of this unique creature, just scroll down this post to the very bottom. I found quite a few videos of this creature off of the Chinese website tudou.com and soku.com, and the Chinese documentaries and expeditions to find more information about it.

I was made aware today of a very interesting viral video that has been on the Youtube universe for a few years now. So far, it has already gained over 10 Mil views. Apparently there is even more old videos of what appears to be a very tall chinese/asian looking ape-like creature from the Chinese internet sources, which I found.

Just like the North American Bigfoot, the Chinese media also like to bring up this case on occasion to have “experts” discuss this person. Apparently very little information is known about him except maybe 1-2 minutes of reel on him, walking around and squatting in a very primitive fashion.

What I do know for a fact, from a lifetime of being fascinated with the paranormal and supernatural is that maybe half of the cultures in the world have some story about giant primate type animals that lived close to humans.

Bigfoot, Sasquatch, Alma, Yeren, Yeti, Abominable Snowman, etc. these are all labels we have given these animals.

In the video below, we see a human that is clearly very tall. His head size compared to his torso and his arms, legs, limbs is just incredible. The average length ratio of most human’s heads to overall body length is supposed to be 1/8.5, but the head/body ratio seems to be much greater here. Personally, I estimate the size of him to be around 7 feet tall, which is tremendously unusual, similar to the case of Siah Khan, the 8 feet tall Iranian farmer. However, if you look at the way this Chinese giant is walking, he seems to be just fine with no ailments. His ability to cognitively function is obviously not at the level of most humans.

If this person only had that shaped head without his great size, then most people would have written his mother’s story about being raped by a Yeren as fake. However, it is his great height and size that is most striking. We realize that the most likely medical explanation is that this human just suffers from microcephaly similar to the Pinhead from the old Freaks movie. Wikipedia says the name was Schlitzie. However, Schlitzie only stood 4 feet tall. This chinese version of a microcephaly seems to be 7 feet tall, if not more.

Of course, we have to realize that this creature/human’s body would look big compared to most Chinese women in the rural area. When we look up the Wikipedia article on Microcephaly, it states that most babies that have shrunken brains develop dwarfed bodies, not giant sized bodies.

This is not the only thing. Pictures from the videos of this Chinese Yeren shows underneath the hair on his head that he had grooves on his skull, similar to the skull of gorillas. I personally don’t understand the Chinese being spoken in the video but I can guess from the pictures that the researchers are analyzing that they are focusing on the head, to see whether this yeren was really human or some type of bigfoot hybrid.

I am not willing to say that this Chinese giant is the missing link, or a human-bigfoot hybrid. His mothers claims of being raped by a Chinese Yeren is also very suspicious. When you look at the video, obviously you know it is not a man in a suit, like people who do hoax for bigfoot sighting. The creature is nearly completely naked. This is video which seems to have been shot decades ago, so there is probably no video editing or graphics design done. The story is probably real, this human did exist, but most likely dead now.

I was informed today of a most interesting case. There was a well known actor who was on the show The Golden Girls back in the 1980s, named Brent Collins, who apparently had the medical conditions of dwarfism and marfan’s syndrome.

The general claim made by the sources I find on google is that this guy had a growth spurt as an adult, maybe around the age of 30 or higher. This is most unusual. The only case which most people had found similar is Adam Rainer. He died in 1988 from a heart attack, which is believed to have been induced by the growth spurt.

Some people on the TheTallestMan.com forums say that he started growing at the age of 46, which was just a year before he died.

There are maybe just a few videos on Youtube of him acting, and if you look at his body, his arm limbs are abnormally long. Since we can’t really get a good look at his legs, I will just assume his legs are also disproportionately long compared to his body.

Here are some things that have been guessed by others who tried to analyze his unique case.

Roger – I guess his dwarfism might be caused by an osteodysplasia, due to a genetic mutation, (not sure what kind of dwarfism, maybe SED dwarfism) rather than an endocrine origin, and although radiographic evidences show that development in epiphyseal regions in subjects with SED dwarfism is markedly delayed, when reached the early adulthood the plates shoud be closed, so I do find extraordinary that the epiphyseal plates of Mr.Collins were potentially functional at age 46, unless the ossification centers remained open due to some circumstance. Looks like, as long as he was working, he didn’t show any sign of MFS, as we can see on the 1987 Another World video, so I am surprised that marfan developed so spontaneously, and killed him so fast. (source)

GodsGadfly – I just saw his appearance on _The Golden Girls_–and apparently garnered a few search hits from it. If you know what you’re looking at, you can tell that his arms and fingers were very Marfanoid in proportion to his body, and relative to the normal proportions of a dwarf. I had gotten to wonder if he had Weill-Marchesani Syndrome, but that is not associated with aortic dilation. (source)

It seems that we might be incorrect in assuming that he died at the age of 48, but instead 46.

Can we extrapolate this very unique medical case of this rather good actor to something we can take away?

Brent Collins was said to have started growing around late 1987 and that triggered the heart problem, which is a Marfan’s symptom, to have a problem, causing his death.

It doesn’t make any sense at this point how this man, who would have been in his mid 40s could have still had functional growth plates. I once theorized in an old post that maybe it is possible that a very small minority of females still have functional growth plates even into their 30s, but this case is much more extreme.

Human bones are very hard material that is not malleable using normal magnitudes of force. Maybe, just maybe, because Collins was a dwarf, probably weighing just around 60-80 lbs, the cartilage in his body did not ever experience the amount of gravitational loading needed to ossify the epiphyseal cartilage.

Of course, now I am just completely guessing.

These are the exact words someone told me today. How often do these words come out of someone’s lips?

Enough times in my life to realize that height is very important for some people.

I decided to try a new gym today and could not get any type of Guest Trial Pass in the local LA Fitness close to my house. Did some searching and found out that while I can’t get a guest pass when I an physically at the facility, I can apply for the pass online, fill out my info, and then take some barcode to be scanned in. So I did that. Went to the gym, and showed it to the trainer/worker at the front desk/guest location, where they check people in. Apparently they don’t get enough people like me so they didn’t really know what to do so I was escorted to be sat down with another worker to put my personal info into the gym database. I mentioned that my name was already in, I didn’t want to take any gym tour, and just wanted to play around the gym to see if I wanted to switch from the YMCA, which had a higher monthly gym fee. The worker asked me what I wanted to do and I replied that I just wanted to play basketball.

So he mentions that he loves basketball and used to play a lot. Then he had to take the job at LA Fitness and couldn’t play much anymore. So I make the off-handed remark (which was also a joke) that all all he needed was to “be a little taller and have a little more skill to become a professional basketball player”. Then he says “I wish I was taller”.

A 2nd look at him tells me that he is already 5′ 11″, maybe even 6′ 0″. White, in his 20s, bearded, seems to be bored of his job, but goes through the motions and decently polite.

Apparently being even 5′ 11″ (or even 6′ 0″) is not enough anymore. He is still wishing he is taller. At what point does a normal guy stop wishing that he is taller? 

I think back in my life to the number of people who I have met who desperately wished that they could just grow taller.

The most extreme case was a Southeast Asian girl I dated for a short time. She would mention her short stature and tell me in confidence that becoming taller was her main wish in life. Not making more money, not getting married, not becoming successful. I would ask her whether she would choose ten million dollars or 9 inches in height. She choose to be taller. That relationship did not last.

Do these people, become bitter and resentful at some point at people who are taller than them after they reach a certain age and realize that there is almost nothing that they can do to change something about themselves which they don’t like?

Readers: I plan to do a short series of posts on topics related to medicine and biohacking in the next few weeks, sort of as a short guide on how to improve other areas of one’s body.