One way to develop new height growth techniques would be to study how the hydrostatic skeleton works and since hydrostatic pressure is a key way that hydrostatic skeletons stay structurally sound.  We can use the methods that hydrostatic organisms generate hydrostatic pressure and use those methods on our endoskeletons.

“A hydrostatic skeleton or hydroskeleton is a structure found in many soft-bodied animals consisting of a fluid-filled cavity, the coelom, surrounded by muscles.”

Here’s an image:

Another description: ”

A hydrostatic skeleton is one formed by a fluid-filled compartment within the body: the coelom. The organs of the coelom are supported by the aqueous fluid, which also resists external compression. This compartment is under hydrostatic pressure because of the fluid and supports the other organs of the organism. This type of skeletal system is found in soft-bodied animals such as sea anemones, earthworms, Cnidaria, and other invertebrates .”

“earthworms move by waves of muscular contractions (peristalsis) of the skeletal muscle of the body wall hydrostatic skeleton, which alternately shorten and lengthen the body”<-earthworms grow shorter and taller almost at will.

Another description:

“A hydrostatic skeleton is a structure found in many cold-blooded and soft-bodied organisms. It consists of a fluid-filled cavity, which is surrounded by muscles. The cavity is called a coelom and in some animals this cavity is filled with a blood-like substance called haemocoel. The fluid presses against the muscles, which in turn contract against the pressure of the fluid. The fluid is incompressible and thus maintains a constant volume against which the muscles can contract.”

Maybe high hydrostatic pressure in bone serves as a temporary hydroskeleton which allows for temporary loss of osteo-structural components and allow for things such as the growth plate.  Maybe we need to stop think of it is an osteochodral skeleton but a hydroosteochondral skeleton where the hydroskeleton allows the skeleton to function without all the osteocomponents.

ONTOGENETIC SCALING OF HYDROSTATIC SKELETONS: GEOMETRIC, STATIC STRESS AND DYNAMIC STRESS SCALING OF THE EARTHWORM LUMBRICUS
TERRESTRIS

“Hydrostats are constructed of an extensible body wall in tension surrounding a fluid or
deformable tissue under compression. It is the pressurized internal fluid (rather than the rigid levers of vertebrates and arthropods) that enables the maintenance of posture,
antagonism of muscles and transfer of muscle forces to the environment”

“The major source of static load on the body wall of a hydrostatic skeleton is internal pressure (P). Pressure can be generated by the contraction of muscles in the body wall surrounding the incompressible fluid and/or by mechanisms such as ciliary pumps (e.g. in sea anemones), osmotic pressure (e.g. notochords) and gravitational pressure (the gradient of pressure produced in a static fluid by its own weight”

“hydrostats tend to be highly deformable”

“The main source of loading on the skeleton of most terrestrial organisms with rigid skeletons is body weight. In earthworms, the main source of loading on the skeleton is internal pressure (generated by body wall muscles contracting against a constant volume of internal fluid)”

“The upper limit to the size of hydrostatic skeletons is unclear, but some of the possible limitations to giant earthworms include (1) a decreased respiratory surface area due to the low surface-to-volume ratio compared with that of smaller earthworms, (2) an increased importance of gravitational pressure as a source of load on the body wall, (3) an increased frictional resistance to burrowing, and (4) the exponential increase in the cost of tunnel construction with increasing body diameter”<-An upper limit to hydrostatic skeletons would not be good as it would imply limitations on generation hydrostatic pressure but none of these reasons would seem to impede a structural limitation on hydrostatic skeleton size.

Scaling of the hydrostatic skeleton in the earthworm Lumbricus terrestris.

“We used glycol methacrylate histology and microscopy to examine the scaling of mechanically important morphological features of the earthworm Lumbricus terrestris over an ontogenetic size range from 0.03 to 12.89 g. We found that L. terrestris becomes disproportionately longer and thinner as it grows. This increase in the length to diameter ratio with size means that, when normalized for mass, adult worms gain ~117% mechanical advantage during radial expansion, compared with hatchling worms. We also found that the cross-sectional area of the longitudinal musculature scales as body mass to the ~0.6 power across segments, which is significantly lower than the 0.66 power predicted by isometry. The cross-sectional area of the circular musculature, however, scales as body mass to the ~0.8 power across segments, which is significantly higher than predicted by isometry. By modeling the interaction of muscle cross-sectional area and mechanical advantage, we calculate that the force output generated during both circular and longitudinal muscle contraction scales near isometry.”

Negative pressure is a potential novel technique that can be used to manipulate height growth but there is nothing in the evidence to suggest that it will increase height growth.  The main selling point behind it is that it’s novel and is inversely related to the concept of LSJL(which wants to increase pressure).  The inverse relation may actually eventually prove useful as you could do rapid sunctioning and unsunctioning to build pressure or you could cup every area other than the epiphyseal region of the bone(But the blood just seems to rise to the area of sunction not to other areas).

Here’s a cupping device:

Cupping essentially manipulates fluid and blood flow.  So is there a way to use such a cupping device on the bone or maybe the cartilage?

The device is not expensive:

Rather than cupping the back, you would cup the synovial joints or epiphyseal region if this had any potential to work.  The bruising redness often seen with cupping is reported to be caused by a discharge of blood from the vessels but can this be used to induce height growth.

First, this would have to manipulate the blood within the bone itself and it’s possible that it does because blood vessels are interconnected but in addition it would have to manipulate blood flow to increase hydrostatic pressure in the epiphyseal region.  You would either have to put the cup on the target area or everywhere but the target area.  If cupping makes the blood flow it has to go somewhere and unfortunately it seems to head into the red spots seen post cupping.

One thing that could be done is to rapidly cup and uncup a region creating a pressure gradient.

I think cups like this with might work better for that:

According to this cupping website, cupping can activate the secretion of synovial fluids but I’m not sure that can cause height growth unless their are nutrients in the synovial fluid that can stimulate endochondral chondrogenesis.

Cupping is basically the inverse LSJL.  LSJL involves lateral tissue compression whereas cupping is negative pressure.

According to Effect of Negative Pressure on Human Bone Marrow Mesenchymal Stem Cells In Vitro:

“The aim of this study was to determine how low-intensity intermittent negative pressure affects the differentiation and proliferation of human mesenchymal stem cells (MSCs), as well of OPG and OPGL mRNA expression in MSCs. MSCs were isolated from adult marrow using the density gradient separation method, passaged for three generations, and divided into the vacuum group, which was administrated at pressure of −50 kPa{So LSJL involves positive pressure and this involves negative pressure}, for 30 min at a frequency of 2/d, and a control group. The differentiation of MSCs was examined through inverted phase contrast microscopy, measurement of alkaline phosphatase activity, alizarin-red staining, and immunohistochemistry for type I collagen, hypoxia-inducible factor-1α (HIF-1a), and vascular endothelial growth factor (VEGF). The MTT assay and flow cytometry were used to measure proliferation and apoptosis. Real-time PCR detected the expression of mRNA from OPG/OPGL. Compared to the control group, there was a decrease in the proliferation of cells in the vacuum group. The number of cells in S phase was reduced by 62.4%, while the rate of apoptosis, the activity of ALP, and calcium release all increased under vacuum conditions. Calcium nodes could be observed through alizarin-red staining, and the expression of collagen type I, VEGF, and HIF-1a were increased significantly. Expression of OPG mRNA was increased and the expression of OPGL mRNA decreased in the vacuum group relative to the control group. In conclusion, low-intensity intermittent negative pressure can inhibit the proliferation of human MSCs, induce differentiation to bone cells, promote the OPG mRNA expression, and reduce OPGL mRNA expression.”

This sounds like something unhelpful for height growth unless you make MSCs undergo a chondrogenic versus an osteogenic lineage but you never know.

I found an interesting observation while evaluating my finger progress.  I realize that a lot of this may be confusing to understand as I’m not explaining it very well.  But the core idea is that when clamping you tend to clamp the same way every time and that may be supoptimal to growth.  That may foster angular growth which may slow the overall longitudinal bone growth process so if I find a way to balance the clamping I can grow straighter/faster.  I’m also trying this on the bigger bones in the legs and arms too.  It’s just a lot easier to monitor progress in the fingers and I don’t have to worry about clamping force being a limiting factor.  The entirety of my body can generate enough force to clamp the finger.

If you don’t understand don’t worry about it.  I’m just letting you that I had a methodology epiphony and am still working on finding a way to grow taller.

You can see that the right pinky finger is slightly crooked.

You can see that the pinky is crooked in solitude as well.  This is likely due to the fact that the way I’ve been clamping has resulted in the bone tilting in a certain direction.  If only one side of the bone has been growing that won’t result in as much longitudinal growth as could be as it will be weighed down by the shorter side.  Naturally you tend to clamp the same way every time so I’m adjusting it to try to see if I can fix the angular growth.

So for instance rather than clamping like this.  I’m going to be feeling what parts of the bone are underclamped and try to focus on clamping at that angle.  Underclamped regions of bone don’t feel as thick and tend to feel to smoother than the other regions of bone.  For instance like:

I’m clamping the right hand pinky phalanges on the epiphysis of the distal phalange on the inner side but the middle phalange on the outer side this could result in crooked growth.  For the lower areas it’s inner medial/outer proximal and inner proximal/outer metarcapal.  It wasn’t intentional but I tended to clamp the same style every time.  Actually when I was clamping my thumb I was clamping around the proximal phalanx on both sides and I do not see signs of curved growth but I will try clamping more on the distal phalanx to see if that can inspire more growth

I realize this may be hard to understand but I’d rather focus on doing it rather than trying to draw some diagrams.  It’s possible that I will go back in the future.  So now what I’m going to do is invert it.  Clamp the middle phalange on the inner side and the proximal phalange on the outer side.  It’ll be very difficult to do this on the proximal/metacarpal intersection this way due to the web intersection.

If inbalanced growth is an issue and this new hand clamping strategy corrects it then this will be the LSJL proof I’ve been looking for as angular growth can severely reduce overall growth.  If only one side of the bone is growing you’re going to get angular changes but not much longitudinal bone growth until both are growing so if I manage to correct this it will be a huge improvement.

Whether you be a skeptic or a believer regardless I’m going to try to change my clamping technique and I’ll either have strong evidence of LSJL or not but adjusting clamping this way already feels different as one part of the epiphysis feels a lot more underdeveloped than the other.

For the longest time, I had thought that the researchers who look into generating and regenerating bone tissue and cartilage tissue had no plans or desire to try to get bones to be increased in size aka volumetrically increase.

I was wrong. I have been very, VERY wrong.

In a recent Discover Magazine article, I finally realized that this belief that the average orthopedic researcher looking into tissue engineering and growing replacement organs would never think of applying their knowledge for the goal of helping adults grow taller was all wrong.

Let me show you guys what I mean.

1. Buy this magazine, that might still be in magazine stands right now, in every Barnes & Noble bookstore in the country. “Discover Magazine Series – Secrets of the Human Body” – SCB014 2016 – (UPC: 074470583509)

2. Flip to page 143, and read that single article. It is entitled “Extreme Enhancement – How Nanotechnology could turn us into 8 ft-tall super-athletes” by Mark Miodownik (University College London) –

Let’s just take 2 paragraphs from this article, the 1st and the 4th.

1st paragraph

“One of the most powerful applications of nanotechnology is the design of replacement organs, such as livers, kidneys, and eventually hearts. This will have an enormous impact on those in urgent need of donor organs, but also opens up the possibility of super-organs.”

4th paragraph

“Bioscaffolds are also successfully being used to develop replacement bone for reconstructive surgery. Whole bones can’t be created yet, but success in this arena will not only change the science of hip replacement, it may also lead to new type of cosmetic surgery in which wholesale changes to body shape are carried out. Want a pair of long, slender legs? Have a pair grown for you – and why stop at 6 ft?”

My Personal Interpretation

Reread the 4th paragraph, and tell me how you the reader interpret what he is saying. This guy has admitted that one of the main goals of tissue engineers and biomedical engineers have always had when it comes to figuring out how to regrow full bones was to allow people to possibly grow taller, as adults to the height and size that they want.

I once asked my friend who is a software engineer who works on really crazy high level technical problems why it seems that the young full of energy startup computer entrepreneurs never take on the really hard, really important questions. What he said to me made me change the way I thought about things completely. I was complaining that it seemed like you would have groups of MIT trained CS majors who decide to try to start the 17th health data collection app or the 34th payment system app, which has already been done multiple times before. Why do these young kids only work on simple, easy problems? It turns out it makes the logical sense. Once you have become successful and have made some money from creating that small app, then you move onto something bigger, a much bigger and harder problem when you have more people, employees, and capital.

The point is this: For the longest time, I have been complaining about the fact that no tissue engineering researcher or group who is trying to regenerate hyaline cartilage has ever come out publicly or claimed that the reason they are trying to do their project was because they wanted to regenerate new epiphyseal cartilage which will be re-implanted into human bone tissue, to expand and volumetrically grow the size of that bone. That is essentially increasing the human body’s height using tissue engineering. It turns out the reason they have not is because the problem is too big, too crazy, and too out of reach. It is smarter to start with an easier problem, just trying to regrow the hyaline layer of cartilage in the articular cartilage of the ends of the long bones in the legs.

I had written a post about a month ago showing that the world’s current hottest Biomedical startup is Samumed, which has their own treatment/injection which is supposed to treat osteoarthritis aka cartilage degeneration. A Venture Capitalist had said that if you can get just 1 mm of articular cartilage regenerated from a simple injection, the company that is created from it would be even bigger than Apple. Solving the medical condition of osteoarthritis is much easier, and feasible than getting a full hyaline cartilage with mesenchymal stem cells embedded in the exact correct formation grown in the lab. This is the intermediate step, which is already a multi-billion dollar opportunity for anyone who has success.

Basic message: Start with something small, and easy, and once you gain some success, you move onto the bigger, harder problems.

So far, let’s to a recap of the teams of researchers which are either really close, or already there.

1. EpiBone: Professor Warren Grayson and Professor Gordana Novakovic will be involved as scientific advisors for this lab-to-reality company. The Paypal and Palantir founder billionaire Peter Thiel has put his own money to back this venture.
2. Teplyashin’s Team: They got the tissue engineering approach to lengthen bones to work out years ago but they were stopped from testing this bone lengthening technique on humans by the Russian government.
3. Robert Ballock and Eben Alsberg’s Research: Their research grant filed with the USA government was completed months ago and their published papers show that it was successful.
4. Lawrence Bonnasar’s team: His work at Cornell and the whole spinal implant shows a lot of promise, which I had written multiple posts about before.
5. Atala’s team: His research at Wake Forest University and the pictures of the lab grown fibrocartilage ear scaffolds are sort of the classic. His team probably won’t be the one to get the hyaline cartilage generation done first though.
6. CellInk – Any company that does 3D-Bioprinting, using stem cell infused medium ink will help with the cause. I personally met the Swedish company’s founder, and his son in a Tissue Engineering conference last year. Super nice guy.

Termis Conference: The termis conference is THE biomedical conference that anyone who is interested in trying to figure this thing out should be attending. The word Termis refers to Tissue Engineering and Regenerative Medicine International Society. This is the EXACT niche area of study who will definitely be the group who figures out this problem. In the past years of the annual Termis Conferences, the key people who I have said we should be following their work have attended it.

Overall Message: The people who are trying to regrow bone and cartilage tissue using the basic tissue engineering method of using a scaffold seeded with stem cells and than lab grown (aka in vitro) has always understood the possibility and implications of using their technology to make people taller.

It is very rare that something comes from another source or website written in the english language which actually teaches up something because we have always thought we sort of knew 99% of all of the relevant information and studies that are released on the subject of height increase. This is something that we were only made aware just a couple of hours ago.

It seems that a very small blogspot post (http://authenticheightresearch.blogspot.com.co/) has linked to our website, and in that article, the writer mentions a compound which I have not heard before. Ibutamoren. Whoever wrote these 2 posts clearly did their research, and used some of the information that we have discovered and gathered, since they obviously have read our news on Teplyashin’s research and the effects of Relaxin.

In their post on how it might be possible for people with open growth plates to easily grow taller, they basically propose orally ingesting a dozen compounds which all have effects which stimulate the levels of IGF-1 and HGH in the subject’s system. Plus, they cite all of the studies that are backing up the claims.

• L-Dopa (500 mg) – Increases GH levels by 1000% temporarily
• GABA (5 grams) – increases GH levels by 525% temporarily
• GABA (3 grams) – increases GH levels by 400% temporarily
• Glutamine (2 grams) – increases GH levels by 400% temporarily
• Arginine (9 grams) – increases GH levels by 220% temporarily
• Ibutamoren (25 mg) – Taken daily for 2 weeks increases 24-hour Growth Hormone levels by 97%.
• Ibutamoren (25 mg) – taken daily for 2 months increases IGF-1 levels by 40%
• Ibutamoren (25 mg) – taken daily for 1 year increases IGF-1 levels by 20% on average
• Creatine (20 grams ) – increases GH levels by 83% temporarily
• Casein (36 grams) – taken daily for a week will cause IGF-1 to increase by 15%.
• Milk (3 glasses a day) – increases IGF-1 levels by 10% and increases milk’s bioavailability.

So how much to take, and for how long?

The poster recommends taking 25 mg of Ibutamoren for 3 months, and this is to gain 1 full inch of height. 

(WARNING: This is all the poster’s research!!) – Supposedly it takes about 126 IU of GH Injections in HGH therapy to help the still growing kid get 1 inch of height. This is over a 3 month time. He/she/the poster then divided that 126 IU by 90 days to say that there is supposedly about 1.4 IU that is used by the patient’s system each day. Apparently, adolescents used around 700 micrograms of GH that is naturally produced in their bodies each day. That 700 micrograms converts to 2.1 IU. You combine the 2.1 IU that is used up by the child and the 1.4 IU that is created by Ibutamoren.

The poster cites this study “Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults: A Randomized, Controlled Trial” as saying that taking Ibutamoren repeated does not decrease its effects.

Our Thoughts: A lot of theses studies that show that taking something like Ibutamoren increasing height and having a noticeable effect on the levels of IGF-1 and GH are always done on lab rats/mice. The person who wrote this post did not read through the articles they cited in their entirety.

We always err on the side of caution and say that this person’s claims on the ability of Ibutamoren should be downplayed, although we can say that it is possible that it could work. When you actually look at the effect of Ibutamoren being taken from the 2 week range, the 2 month range, and the 1 year range, clearly you see that the ability of the chemical compound to keep the IGF-1 levels elevated drops, due the human body’s own tendency to reach some level of homeostasis. You go from 97% elevation, to 40%, to 20% by the time the time range for the experiment is pushed to 1 year.

If you talk to any bodybuilder who has used steroids they would just say “DUH” since any foreign compound will have its effect diminished over time by the body. That is why bodybuilders have this idea of “cycling”. You take the GH level stimulating drugs in a cycle, intermittently.

I haven’t personally done any level of research on Ibutamoren but a quick Wikipedia article on it says that it is a GH secretagogue (analog of GH-releasing peptide (MK-677)). It also promotes the ghrelin receptor. What is sort of surprising for me when reading the Wikipedia article on it is that it can raise by the IGF-1 and the GH levels without also raising the cortisol levels as well.

Here is what we can say for sure. If we can show that the effects of Ibutamoren decreases at a much slower rate than say Glutamine, GABA, and L-Dopa, which all can raise the GH levels in the body to a much greater degree, then we can say that “it’s effects doesn’t decrease with repeated usage”.

We DO NOT recommend trying to use this compound for the kid who is just starting puberty. However, we do recommend using this chemical compound for the 14-16 female girl who has sort of stopped growing taller, as well as the 16-18 year old boy. This type of compound is used as a last resort, when the teenager realizes that their growth plates are just about to close, and they are trying to push that last inch of growth out.