Since we are in the subject of trying to become taller, we are fully aware of the largest online communities in the English language websites on the public side of the internet. The MakeMeTaller.org and LimbLengtheningForum.com are two forums which probably have the most discussion on the subject of LLS. Sometimes there are more public cases. That is what happened when a poster in the reddit.com/r/short subreddit thread did a Ask Me Anything (AMA) for the members of the /short group. So far there have been around 181 comments and replies, which is definitely A LOT more than the usual number of comments left on any regular topic or post.

Let’s summarize this more public talk, since the poster did show a few pictures of himself before and after the surgery.

Before Surgery Height: 5’ 1”
After Surgery Height: 5’ 6”
Current age in June 2016: 21

This young male individual does have a girlfriend, who seems to be very supportive. She knew before he decided and told her about the LLS that he had a lot of insecurity and issues over his height. She didn’t want him to go through with the surgery but she did understand why he wanted to go through with it. She herself is also on the short side but she doesn’t have the type of psychological hangup on height like him. She does not fret over her height, so she will never want to get the surgery. If she did have a similar level of issue as him, he would support her in her decision to get the same type of cosmetic surgery.

As the poster notes “I would only recommend to someone who really, really wanted it. It is not something you can do on a whim. It’s a long journey…”

As for his friends, he will just tell his friends that his sudden jump in height is from a late life growth spurt, which is completely reasonable and acceptable.

As for telling people, he did not tell most of the people in his life of his decision to get this cosmetic surgery. He did tell his family about his decision, as well as his best friend. His family did support his decision of getting the surgery and even paid for the surgery. It seems that the family did understand his psychiatric issues over his short stature and probably understood at a deep level that getting the surgery might be the only way to give him some type of peace of mind. The parents must be at least reasonably well off and have enough for this type of surgery since it can be more than $100K for something like this. In addition, the parents were also very supportive. Even his grandfather was supportive of his decision because his grandfather is also quite short and had to deal with a lot of psychological anguish in his own life for this short stature. It really didn’t take that much explaining and convincing for his parents to understand. They already understand before he ever mentioned it just how big of an issue being so short was for him. They got it.

Height of the rest of the family

Father: 5’ 6”
Mother: 5’ 0”
Sister: 5’ 0”
Grandfather: 5’ 0”
Grandmother: 5’ 3”

As we can see, the family he comes from is genetically predisposed towards short stature. Medically, it would be called Idiopathic Short Stature.

The Real Surgery Parts

• Ethnicity: He is assumed by many other redactors to be “white”
  Total Cost: $130,000 – NOTE: Let’s remember that this high cost is actually a total cost for 2 different surgeries, one for the femurs, and the other for the tibia. Most LLS that are at the 7-7.5 mm LLS industry limit length limit is only for 1 set of bones, either the femur or the tibia, and those individual surgical operation usually cost more around $70,000. It is most likely that the $130K price is broken into something like $70K for the femurs and $50K for the tibia, and the other $10K for everything else. The $130K is for everything, including surgery, medications, wheelchairs/equipment, physical therapy, hotel, etc.
  Type of LLS Method Chosen: PRECISE 2 (Internal)
  Type of Nail Size Used: Don’t Remember, however he says the weight bearing of the nail was 50 lbs. It might be enough info to find out the exact nail size from just this.
  Level of Pain from a 1-10 Scale: Definitely 10 sometimes, but it seems this particular poster was able to handle it.
  Bones Broken: Both the Tibia and the Femur. Technically all 4 of the major long bones in the lower part of the human body was separated and slowly separated.
  Number Of Surgeries: 2 Major Separate Surgeries.
  Which bones were more physically painful?: Femur – The reason is because you go into pain every time you have to sit down on something hard or use the toilet sitting down. Since we are assuming the person is going to be resting in the hospital, the only time they will ever be sitting down on something hard, would makes perfect logical sense that to be only in the bathroom when using the toilet.
  Which bones were more psychologically difficult?: Tibia – The poster talks about something called a “Dorsiflexion splint boots” (no idea right now) and it must be worn at all times, even at night when going to sleep. I would assume this device makes it always uncomfortable.

  Frequency of Serious Complications and Side Effects from Choosing PRECISE from Paley: Very Low. I did a full post on Paley years ago. He is supposed to be the Absolute BEST, most experienced LLS Surgeon in the world, and his prices show that.
  Amount of time need to recover (to near 100% level): 6 months AFTER THE LENGTHENING IS DONE (So it is actually more like 9 months, at least for this individual person’s case).
  Amount of time to actually do the lengthening: 3 months
  Lengthening Rate: The poster increased his height by 5 inches, or 127 mm. He said that it took him 3 months to do the lengthening. That is only 90 days. However, there was not 2 bone cuts, but 4, so that means that the tibia and the femurs were lengthened every day in a consistent rate. Instead of it being 127/90 = 1.41 mm per day, it is actually 127/(90*2)= .70555 mm per day. That is exactly the suggested maximum rate of bone lengthened we have found mentioned multiple times before in the Make Me Taller and Limb Lengthening Forums. 0.7 mm of femur and/or tibia lengthening seems to be the exact industry.
  Amount of Lengthening Done for Each Bone/Femur/Tibia: 3 Inches of Increase in the Femur and 2 Inches of Increase in the Tibia
  Can you feel or notice the rods in side your bones? No. That is why Dr Paley is considered the best, and he invented this new Internal Method. There is a reason why it is called PRECISE.
  Exact Medical Center or Clinic: Paley Advance Limb Lengthening Institute.
  Exact Physician That Did The Surgery: Dr. Craig Robbins. Both he and Dr. Paley do an incredible job.

After the Surgery: You wake up the next day after surgery in pain, but the nurses will obviously give you the pain meds. You are then asked to stand on a walker, which will probably be extremely, extremely difficult to do. After a few days, you start physical therapy. There is supposed to be a bicycle machine called a Nustep (???) and the therapist will basically stretch as much as possible the muscles in the legs for the months that you are doing the bone stretching to make sure that the muscles also lengthen/stretch along with the bones that are mechanically being stretched in a very linear, systematical way. – “…The precise device in your leg uses telescoping rods that extend with turns from and electric magnetic device that you place over the osteotomy sight until your desired height is met or until the rods reach their maximum of 3 inches”

“I was not really bedridden…. I did go through a period when I used a wheelchair out and about, but I always used a walker at daily PT. It was pain was so great I wouldn’t wish on anyone. It takes a tough SOB but all of the guys there doing it all seemed like the results were well worth the pain. They do keep you doped up quite a bit for the most part which helps at times…”

You can either choose to get around the hospital/clinic in a walker or a wheelchair, but the walker will be much slower.

Other Notes: “…you can have both surgeries (this guy did both his femur and his tibia) relative close together and in some circumstances at the same time. Lets say 2 months wheelchair 3 months walker 1 month full weight bearing but seriously taking it easy. You don’t really use crutches unless you are only lengthening one leg.”

Commentary: If I remember correctly, I think the PRECISE technique, which is internal was invented and patented by Dr. Dror Paley himself. I remember looking through Paley’s CV and it said that he had been working on the technique for at least half a decade or so perfecting this new internal method. I remember it might have been around 2013 when I did the first post on the new technique, which is supposed to be much better, in terms of less complications, less side effects later on, and maybe even faster bone healing time.

Complications or Side Effects: from the poster “…my muscles are still a bit tight and they do seem to be pulling on my knee a bit. Sometimes that can be painful… I really need to do some laps in the pool so that won’t be a problem anymore! “ – “I and most other people were told to stop a bit early before the 6th inch because you can get too tight and then experiance something called “drop-foot”” – There was some loss of feeling around 1 inch from the incision sight in the left leg for a short while, but the surgeon told him that it was a normal symptom which goes away after about 5-6 months.

Myths About LLS:
Myth #1: you’ll never be able to play sports ever again. – NOT TRUE: He was able to go on hikes and even do sprints in a few more months, which we have seen from another older youtube personnel who showed us himself running. It seems that about 1 year after the surgery, after the bones have completed healed, he would be able to play sports again.
Myth #2: It is not offered in the US – NOT TRUE: It seems to be at least offered in California, Florida, and New York.
Myth #3: If you suffer from any type of psychological problem that is associated with your height, you can’t get it – NOT TRUE: It seems almost all people choosing to do LLS do have at some level body dysmorphia, height dysmorphia, or some type of real serious type of insecurity or hangup. Dr. Paley fully understands this critical aspect. He realizes fully that the only people who are desperate enough to allow another person to break their bones already have serious psychological issues with their height. Dr. Paley will definitely preform LLS on those people who have mental issues, and would almost expect that any person who comes into his office wanting LLS to have height dysmorphia already at some level.
Myth #4: There will be serious medical complications from choosing to go through with this cosmetic surgery which the subject/patient does not realize that will pop up years later, long term – NOT TRUE: From the poster “… Dr. Paley, one of the smartest people I have ever met, adamantly says there will be very little to no long term risks associated with the surgery. It’s relatively the same question as whether or not breaking a bone when you’re young effects you when you are 90”

Another Female Volleyball Player he met going through the process who wanted to be taller: 5’ 5” before and wanted to be 5’ 10”

Overall Changes In Attitude Of Life After Surgery: From the poster “…Personally, I felt abnormal before and that made me feel very uncomfortable and awkward. I am still short according to U.S standards, but I’m not abnormal and that makes me feel great. I am the same height or just a few inches away from many of my friends now”

Has there been any noticeable increase in amount of random stranger females attention/attraction for the male after surgery, from gaining 5 inches? Yes. He does believe that the boost in height has definitely helped him out.

Conclusion and Discussion:

“With Dr. Paley’s PRECISE method, you get all metal/hardware removed and you are left with only natural bone when you are done lengthening. Dr. Paley, one of the smartest people I have ever met, adamantly says there will be very little to no long term risks associated with the surgery. Just do some research….I definately had to put my life in the doctor’s hands, and so far he’s done a damn good job.”

If anyone did ask him where did he go and how come he came back so much taller, he would give any normal short lie and not focus on those topics too much. As for this decision and this journey he took, it is his life. He told only his family and close friends. It is something private. He doesn’t plan to talk about this phase of his life that much, and doesn’t plan to explain it to every new person that comes into his life. He will move on one day.

Yes, there is no doubt that the whole stretching part was extremely painful, but once you go through the process, basically you have walked through hell, gone through the gauntlet so to speak, and finally have made it to the other side, where you have lengthened your bones by 5 inches, and have had the physical therapists stretched your muscles also to be 5 inches longer, then your own brain will immediately start to forget the pain.

I remember this wonderful quote from this poster in my high school weightlifting class. “Pain is temporary. Regret lasts forever”. For a very brief short amount of excruciating pain, you will gain a permanent, lifetime of reward and gain. This poster has remarked that in the end, the process was all worth it.

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Something I read recently made me think back to this old adage that drinking milk will somehow make a kid grow taller.

In the early days of the website, I had talked about and argued over the implied correlation between dairy consumption and perceived greater adult stature. There was never any real conclusive proof in the first post, and over time, after a few more posts, I started to switch my opinion that drinking milk could possibly increase one’s height, and increase the rate of height increase.

One particular life incident that will forever be in my memory makes me think back to this idea. I once met two extremely tall german girls, both around 6′ 2″, buying 2 gallons of milk each and telling me that they drink milk similar to how they drink water. Of course, just how much significance should one put into 1 very odd, outlier experience?

Here is a theory I propose which probably will not be possible to be validated without some serious effort by medical professionals, over a long period time that is not reasonable to most researchers.

Drinking Bovine/Cow derived milk does make people grow taller, but it is not in the way that people would hope.

Theory:

1. If you started to take up the practice of drinking milk, even at the age of 10, when one is still growing, there would NOT be any noticeable increase in one’s adult height.
2. However, if you can develop that milk drinking habit, and you also get your children, AND your grandchildren to drink milk from a very early age, basically the moment they are being weaned off drinking their mother’s breast milk, then your grandchildren will be taller from it.

I call it the grandchildren milk height theory, which I will shorten to GMHT.

Now, a lot of my time these days are focused on thinking at a subconscious level about orthopedics and orthopedic research, specifically because I have decided to dedicate my life towards this endeavor. I have personally read over a thousand studies, and there are a lot of ideas that run in the back of my mind. 90% of those ideas that I have while I am driving, showering, working out, etc. I write down but never decide to write up about, because they are either too scientific and have no actionable steps that the average reader can do.

Something that I recently really got into is the idea of using probiotics, or changing one’s gut biome/intestinal bacteria culture or composition. There was this stunning study that was done in fecal transplantation where you take a female who has been predisposed towards being overweight her entire life, and can’t seem to lose weight no matter what she did. She undergoes a fecal transplantation using the fecal matter from a woman who has been thin her entire life, who is predisposed towards thinness. The result is that the previous state of being always overweight is completely gone, and replaced by a women who basically seemed to have changed her genetic makeup. This study that I learned is absolutely stunning to me.

There is now even clinical studies being done to test this idea (Fecal Microbiota Transplant for Obesity and Metabolism) as well as proposed pills sold that is basically “poop”. In 10 years, it is possible that real doctors are going to be suggesting to their patients that they should swallow poop pills to help them loss weight. The most crazy thing about this is that I have read articles by people who have said that if you can created some pill that can help people loss weight and keep the weight off, you would become a billionaire. So it is kind of interesting to think about this idea – “Can a person become a billionaire by selling pills whose active ingredient is human feces?”

The famous podcaster Joe Rogan is famous for saying that he imagines the human species as just a very complex type of bacteria super-organism (Joe Rogan’s Theory on Life and People). In the medical lecture where I learned about fecal transplantation, the professor said that if we didn’t have any type of way to control, direct, and organize the bacteria in our body, we would pop like a balloon or shrivel up like beef jerky in minutes. In our stomach alone, there is supposed to be around 100 trillion microorganisms

This idea that we can change something that would seem to most people so intrinsic, brings back the idea of Lamarckian Evolution, which Darwin’s camp disproved more than a century ago. Before there was Darwin’s theory of evolution, there was Larmarck’s Theory of Evolution, which I have mentioned before multiple times on the site. What I am proposing is epigenetics, which most people who study/do research/work in the biological and medical sciences don’t believe in. Epigenetics and the field is indeed very controversial, and many studies that have been done to see if it is real has not stood up to the scrutiny of medical research professionals.

Based on darwin’s theory on how evolution really works, this theory I propose right now is basically wrong since the mechanism which I propose goes against how darwin explained why there is such diversity in the species in the world. Let’s make that clear.

Whereas Lemarck says that the features of our bodies change to “adapt”  to the the interaction of our bodies with the external world, which get passed onto our children, Darwin says that the changes that we find is due to random variations at birth. The net result of what we see, in terms of variation is from the variations that are not as successful not reproducing as much and dying off. Darwin is right on this point. This idea that we can do something to our bodies and/or genes, and have that change get passed onto our children is extremely unlikely. However, this theory does need to be proposed, since it is a Theory of Leap Of Faith. Its exact mechanism and steps are not completely logical, but there is just not enough data on to completely disprove this idea, since it is in “gray areas”. It just might work.

The Steps in the Mechanics of GMHT.

1. Your start first with the first generation, where the still growing adolescent is given a lot of milk for consumption. – The result is no noticeable increase in height, if we compared their final height to say an identical twin which will be used as the control.
2. This causes their gut biome to change – At this point, I can not tell the reader how the composition and culture of the bacteria in their stomachs will change. Just that the type, composition of bacteria in their intestinal tract will be altered.
3. When the adult female becomes pregnant, they should immediate start to take calcium, vitamin d3, iron, and magnesium supplements, because those specific minerals are the exact ones that the developing fetus is going to be absorbing from their mother’s bodies. This is not just to ensure that the baby born will already be big, but also to prevent any possibility of hip fractures that can develop from the calcium deficiency causing pregnancy-induced osteoporosis.
4. When the first generation has their kids, they immediately get their children, the 2nd generation to start having cow milk into their system immediately after they are weaned off their mother’s milk, which they should continue to consume until their are 2 years old (mother’s milk here, not the cow milk). This will have some dramatic effects on the ability of the develop infant’s body in being able to direct the calcium in their bodies towards the ossification centers in their bone. We are specifically talking about Calcium and VItamin D3 here. The gut biome changes again.
5. When the 2nd generation have their children, they will repeat the steps done by the 1st generation towards the 3rd generation. The result is that the 3rd generation will grow into adult heights which will be noticeable taller than if they were not consuming the milk.

If we were to be completely analytical about this, we can even skip the 1st step. That first step might not be needed, but to explain the basic idea. This is indeed Lemarckian and Epigenetics, but the entire premise behind the website and this crazy endeavor of trying to manipulate one’s almost pre-destined height which is 80% controlled by one’s genetics, we have to use crazy, basically unvalidated ideas which most real scientists say is false.

What I am saying is that we can systematically change a person or a group of people’s heights by changing their gut biome with at least a 3 generation effort with increased dairy consumption to get the high level of Vitamin D3 needed so that when the children are still very young as infants, their immune system has already become altered. The extra Vitamin D3 will help be more effective in directing the calcium in their infant and adolescent bodies to go towards the bones.

It might be surprising but most American adult males are deficient in Vitamin D3 and most females are deficient in Iron and Magnesium.

The physiological changes that can happen are the following….

1. Where once the grandparents (1st gen) were lactose intolerant, the grandchildren (3rd gen) or great-grandchildren (4th gen) are no longer. This is from a systematic almost forced changing of the gut biome to handle it when can be altered when the 4th generation was just an infant.
2. Where once the 1st gen might have had celiac disease and have gluten sensitivity, the 4th generation don’t have it, and most medical professionals with their current testing devices will say that to the 4th generation that they don’t have a genetic predisposition towards gluten sensitivity, even thought their great-grandparents all had it. Same thing for other intestinal system chronic issues, like Crone’s Disease.

This obviously doesn’t sound as scientifically cool as say using the recently discovered CRISPR-Cas9 gene editing tool to create babies will superior height and intelligence, but in my eyes right now, it does sound viable. Like I said, it will take at least 3 generations to notice any effect.

I think back to the insane level of height increase that happened in the Netherlands over the last 100 years and imagine something similar. People are reminded that during Vincent Van Gogh’s era, the average Dutch adult male was quite short, and among the shortest in all of Europe. In 100 years, that stereotype of the Dutch has completely changed. Some people say that the incredible height of the Dutch was always there, just suppressed due to decades of malnutrition and bad childcare. That would suggest that the Dutch, and possibly all Northern Europeans, specifically the Scandanavians, are genetically somehow supposed to be a taller ethnic group than other ethnic groups in the world. Based on just data collection and looking at the tabulated anthropometric data over the last 50 years one can say that.

However, let’s remind the readers that there was a stunning article that the World Health Organization (WHO) published that I found two years ago which showed that when average out, it says that nearly all human tribes seemed to all have the exact same growth potential. That is saying that the stereotypically image of the short vietnamese male of the modern ega may be gone, when the adult males catch up in height in Vietnamese in 100 years to the “tall” dutch” that we find today. It was revealed that the Dutch society adult male did hit a plateau on their average height as early as even 2010, when census data was collected.

Summarizing It All

• I propose GMHT, which says that drinking cow milk will make people taller, but it takes at least 3 generations of it to work.
• You have to get the milk consumption to happen early, right after the baby stops drinking their mother’s milk.
• The goal is to  change the gut biome of the person while they are still an infant, with a malleable immune system that can be altered.
• This idea should work to cure lactose intolerance, which has been linked to the “short asian” idea since most east asian ethnic groups have a high occurrence of lactose allergy.
• The milk has Vitamin D3 in it, which is critical in endochondral ossification development.
• Vitamin D3 will help guide the calcium to the growth plates when the kid is still growing, making the interstitial growth of the long bones to become optimized.
• Adult men have a Vitamin D3 deficiency
• Adult females often have a Iron and Magnesium deficiency.
• When the adult female becomes pregnant, she should immediately start to take calcium, vitamin d3, iron, and magnesium supplements.
• Don’t supplement the just born baby with any supplements. The mother’s natural breast milk is enough to give the baby the right combination of hormones, vitamins, etc to ensure that the baby will have the most “fit” immune system. Nature had 5 billion years to perfect this natural process so let nature do its magic for the time when the mother is breastfeeding. Sometimes we have to take a step back.
• Only when the stage of complete and only breastmilk consumption is over should the now infant be given supplements.
• Add vitamin D3, calcium, Iron, and Magnesium powder in with the milk being consumed, so that the growing baby/infant reaches the full height and growth potential.
• The full height and growth potential has been claimed by the WHO to be the same for most ethnic tribes in the world, not counting certain tribes that are pygmy due to environmental factors like Island Dwarfism.
• This means that the male teenagers from stereotypically short ethnic groups may end up being just as tall as the dutch male teenager in a century or so, if they supplemented their next 3 generation of children and pregnant mother with milk and vitamins, at exactly the right stages.

• Buy Calcium & Vitamin D3 Supplement Pills Here (Jamieson Vitamins) – Recommended Dosage: 2.5 IU/Day –
• Buy Iron (Folate) Complex Here – Recommended Dosage: 1.5 IU/Day – (Post on Iron supplementation)
• Buy Magnesium Here – Recommended Dosage: ??

(Note: This time I did NOT use any Amazon Affiliate links here. Too tired to do that.)

Almost 99% of the messages we get to the email are just not helpful at all and people asking us to post the PDF for the Grow Taller 4 Idiots E-Book, which we can’t do anymore. Sometimes a reader of the website does provide some interesting new information for us to read, and reconsider. This series of emails were given to us by a reader, who goes by the first name Jacob. We read the series of emails, looked at the links, and wanted first to post them down, before we wrote another post giving our analysis and thoughts on what they said, since the entire series of messages is quite long.

May 25th

Hi, Tyler

On making your next post on your website, I suggest a possible further research on this topic.

Do you remember Guy name of Alkoclar and XCrunner mentioning about Methyl Protodioscin?

Well I thought it’s lab made but apparently it’s also extracted from either Tribulus Terristris or Dioscorea Nipponica Makino.

In many of Methyl Protodioscin compound that is sold especially on Alibaba, most of them happen to be extract of Dioscorea Nipponica. Few of them were also extract of Tribulus Terristris. Chemical compound of Methyl Protodioscin nonetheless happen to be C52H86O22. I’m not too keen on chemistry and I had several theories behind this which was shut down by several people.

There are lab made compound of Methyl Protodioscin that is produced in America (several labs I checked) but unfortunately they are only sold to doctors and researchers with chemical lab company ties. Ordinary people may not be able to obtain them or the price is too high for few mg even for sample purpose.

The link below is worth checking out because it says that Dioscorea Nipponica (from ethyl acetate extract method) INHIBITS Pi3K pathway

But we need stimulation of Pi3K (along with CNP expression and IGF-1 and HGH) for bone growth to occur and many of these pathways are dependent on each other.

http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=759832

On May 27th

Found something on Methyl Protodioscin (DNA methylation wasn’t mentioned and am still going to research on this as I go along)

But it says something about osteoclast

From the pdf (attached) … quote below

…… methyl protodioscin， a major constituent ， possessed the strong inhibitory activity both on the formation of osteoclast・and the bone resorption ，…..

On May 27th 

as far as osteoclast is concerned, (if I”m not mistaken), osteoclast eat away the osteoblast and osteblast proliferation is needed for growth (one of many factors) and this methyl protodioscin (particularly) from Dioscorea Spongiosa has shown to inhibit osteoclast behavior and promote osteoblast behavior.

On June 18th

Suggestive idea:

I was thinking… Since Methyl Protodioscin is hard to obtain and they only get released to doctors and laboratory and even if we did obtain them, they are expensive like usually hundred of bucks for few 20 mg or so but we need A lot of them to promote DNA methylation, I have alternate idea which might be cheaper.

Since Methyl Protodioscin is claimed to have the Methylated Protodioscin and the Methylated part just gives off the CH3 to the nearby group, couldn’t we substitute it with SAM-e + regular protodioscin and consume it together?

That way the methyl group from SAM-e gets detached and possibly gets re-attached to protodioscin becoming “Methyl Protodioscin”.

There was a rather famous article that Forbes wrote two months ago talking about the multi-billion dollar company Samumed, started by 6 guys who all originally came from Turkey. The main guy they were talking about is Osman Kibar, who is a billionaire himself as well as a extremely proficient poker player. This guy has a rather extensive history. He went to school at Pamona College, than Caltech, and finally got his Ph. D. at UCSD, which I had the pleasure of dropping by just a few days ago. The article says that he started the company Genoptix while still in Graduate School, which Novartis eventually bought from his for around $400 Million. Not bad at all. Later on, a chance meeting with a old college buddy from school at the airport who worked at Greywolf Capital allowed Kibar to get about $3.5 Mil in funding. That led to Wintherix, which eventually became Samumed.

Apparently Samumed as calculated by the analysts at Forbes is apparently the most valuable biotechnology startup in the world already just based on hype and excitement. Will this be similar to Soon-Shiong’s Nantkwest, who is also started by a rather flamboyant billionaire who is looking to actually solve incredibly difficult biomedical related world problems? On the first glance, the similarities are there.

Without any approved drugs yet, it has already been valued at $6 Billion. Let’s keep in mind that the science and the mechanics on how the treatments work is not that secretive in some black box, unlike Theranos, which only recently was shown to have lied and falsified their claims. As for Elizabeth Holmes, her new net worth of $0 dollars reveals that one must be very cautious when it comes to venturing into the field of biotechnology entrepreneurship. I have personally worked at 2 startup companies who were trying to find treatments for HIV and Cancer (Prostate) and eventually both of those startups went down, due to the inability of the companies to show that their drugs efficacy. We have already talked extensively on the Wnt Pathway before on this website, but it might be worth it to go over the details at a later time. This pathway is one of the 3 main pathways which we have talked about before, which basically is the flow of proteins interacting with each other between the nucleus of a cell and the surface membrane of the cell. There is the canonical pathway, and the non-canonical pathways, as well as the integrated pathways, which as the name sounds, combines certain parts of of the canonical and the non-canonical. (What does the term “canon” mean? That is just another word for original, or general)

So far, the article in Forbes reveals that the R&D people at the company are currently working on 3 main types of biomedical applications.

1. Baldness Treatment – SM04554
2. Arthritis Treatment – SM04690
3. Wrinkle Removal – Not stated in article

The treatment that has the biggest influence would definitely be the SM04690. In the article, it is said that over 27 million Americans suffer from arthritis and every year a supposed 700,000 people get replacements for their knees and another 300,000 get hip replacements.

In terms of the science, after the treatment of the SM04690, when the patients had their knees X-rayed it was found that the space between the femur and the tibia had increased, suggesting that the articular cartilage between the two bones might have regrown back.

This type of news be might not seem that important for us, since I have already written probably 20 articles before showing that thousands of researchers around the world are already working on getting the hyaline cartilage to regenerate to solve the problem of arthritis and osteoarthritis. It isn’t a bold claim to say that the entire goal of all of the Orthopedic Research being done in around the world is all for the goal of cartilage tissue regeneration.

Bone tissue regeneration and growth has already been successful multiple times over.

Here is the excerpt from the article which I have cut and copied below. This shows just how big the solution can be, just for solving the arthritis problem, which is so much easier.

What we are talking about here may sound like a lot of extreme claims but it is honestly not that far away from possibility.

The investor Finian Tan, is basically making this insane claim. If you can create just 1 millimeter of cartilage from a small, quick injection of whatever is the treatment (in Samumed’s case, it is their special formulation) you can create a company that is even bigger than Apple.

The last I checked, on June 16th, 2016, the value of Apple market cap is at $534 Billion. That is insane.

Just think about this for a minute. If you can create just 1 millimeter of cartilage from a simple injection, you will create a company that is worth more than half a trillion dollars. 

Let’s remember something else here. We are not asking the Ph.Ds to create new growth plates here or reopen the growth plates. We are asking the scientists to regenerate the layer of hyaline cartilage that is on the ends of the femur and/or the tibia. That is it.

Yes, we realize that is still hard due to the intrinsic nature of cartilage, which don’t have any vascularization due to the SOX9 gene being expressed, which is actually a good thing. No vascularization means the necessary cells that are usually transported to a wound area for accumulation and wound closure quickly does not get to the wound area.

This arthritis problem is much, MUCH, MUCH easier to solve and figure out than the neo-epiphyseal problem, which is 100X harder, if not impossible, at least in our lifetime.

Here is the last toe/finger clamping progress post.  Essentially, I’m using finger and toe clamping as a proof of concept with LSJL without being limited by force.  I’m still doing LSJL on ankles, knees, wrist, and elbows but also on these smaller joints as well.  Last time someone mentioned hiking as increasing shoe size by two.  Pregnancy also tends to increase shoe size and that could be linked to hydrostatic pressure so that’s why I’m attempting toe clamping.

Here’s the before pic.  It’s not optimal but it’s something.  I’ve been hand clamping my right toe at least 5 minutes a day.  I took this picture on May 14th.  So now it’s been about a month.

I realized that keeping my heel on the floor would make things more level but if I get more significant results I can always go back to the first image.  The right toe looks bigger in the after picture but it also looks bigger than the left in the before picture too.  I’ll have to keep clamping and see if there are further developments.  One thing to note is that shoes feel tighter around my right foot so that’s a positive indication.  Hopefully I’ll keep clamping and will eventually outgrow a shoe.

Here’s the finger clamping progress:

Yeah I know it’s slanted but so was the eariler thumb pic shown in the link above.  It used to be that the left thumb was longer than the right but now they appear more equal in length.  Not much right now but enough for me to try to clamp harder to try to squeeze out more results.

The most promising clamping.  I could always get an xray to validate but with all the other stuff I’m clamping I haven’t been clamping as intently as I could be.

So basically I don’t have enough yet but I have enough indications that I’m starting to get some results so I should try clamping harder/more intently until I have something more concrete.

For fingers I always have the hand xrays I got before so I can get new x-rays and compare.  For toes I don’t have x-rays however if I no longer fit into the same shoe that’s a strong result.